• N&PD Moderators: Skorpio | someguyontheinternet

Has anyone had personal experience with Nucynta/Tapentadol

i've taken high doses of nucynta 300-800 mg and never once did it feel like an opiate. it doesn;t help me if i'm in w/d either even at high doses. all it gives me is that dirty feeling and a headache. BUT, it is great when i take 150 -225mg with my 100 -150mg of oxy dose. great potentiator
 
Oh my, yes...I mentioned this on another thread. On two occasions I mixed the two (say 450-600mg pregabalin and ~300mg tapentadol). The visuals caused by this combination induced were insane, to say the least. Fast moving CEV's conversations with invisible people, and OEV's that put me in an almost delirious state (one example would be seeing people carrying non-existent objects and demanding to have them, causing much confusion). :)

However, I don't think I could, in good faith, reccomend this combination to anyone (unless you want people to think you're truly nuts)

damn i wonder how the hell that combo led to such a state. 8o
 
For days like today when my DOC is not on demand, Tramadol TRUMPS codeine or loperamide as far as that goes.. My liver must be a serious o-desmethyl making machine because 400 mg of tramadol can hold me over when i'm out of the DOC. So yes Tramadol does not produce any REAL opiate/opioid effects, but its in a league all of its own. I can't even compare Nucynta to Tramadol. Nucynta is a mystery to me due its single ring. Nucynta just can't stave off w/d's like tramadol can. I honestly would have to say that genetics are a beg factor
 
sorry for getting off of the tapent subject though. its pure crap by itself. take it with some oxy or hydro and you'll be nodding for hours and it seems to keep you high twice as long imo.
 
if the high is like tramadol and it has the same SNRI side effects then i say fuck it.

You might be surprised. The SNRI effects feel unlike tramadol, and much more like a light dose of amphetamine, with the added sociability and talkativeness. It may not affect many this way (or the feeling isn't yr. cup of tea), but I've always liked it...I've imagined its a bit what a speedball must be like

I would consider myself to have a pretty decent opiate tolerance (75mg methadone to catch a decent high), and the talpentadol can, in the latter 2-4 hours, feel much like a strong hydrocodone high (esp. if I forgo taking any for several days). Tolerance takes a while, but after a few weeks daily you'll notice it.
 
I'm surprised there aren't more positive reports on this drug. I was quite taken with it at first.

Perhaps after it gains wider circulation, maybe?
 
i thought for sure, since everyone said "it's tramadols big brother" or "its similiar to tramadol", that tapentadol would be awesome. No matter what dose i take by itself i cannot obtain any amount of pleasure. like i said, not even w/d's went away with any amount and i went all the way up to 800 mg at times. maybe for the opiate naive or those who actually take their meds as prescribed, this might be up your alley. definitely not for me, and i know the consensus would be that this shit blows by itself. if you're experienced you might try and oxy+tapent cocktail.i even throw in a little zanaflex but not saying you should
 
Nucynta works for me

I have been on opiate medications for close to five years now; I just hit 30 years old. I have been on Percocet 5/325 and 10/325, Vicoden, Norco 10/325, OxyContin 10mg x 6 a day ( but I took at least 12 a day if not more) , Flexeril, Zanaflex, Phentynal patch 50mcg/hr and 25mcg/hr, Phenergan, and Nucynta. Currently I am on the patch at 25mcg/hr every 48 hours (15 a month), Nucynta 50mg @ 160 a month 6 – 8 a day ( I just recently went down from 180 a month), Zanaflex 4mg @ 90 a month (3 a day), Phenergan, and Zanaflex. I have been on Nucynta since early 2010 almost a year now. I wanted to be put on something else due to my dependence on the Oxy. I was asked to try Nucynta and for the first week it was hell. I still had the patch but could feel the w/d from the Oxy, not as bad as it could have been. That first week I aching, felt sick, and slept a lot. By the third week, everything was ok, and my body responded well. My liver function is a little shotty and so is my kidney function due to other issues but is aggravated by medication, but can’t be helped; without it I couldn’t function. I am supposed to take one at a time, but I usually take two which would be like taking 100mg every 4 hours, the Zanaflex three times a day and them my patch which I double up on sometimes. I have a very high tolerance to opiate medication and when I switch meds I build up tolerance quick. Nucynta is expensive but for me that seem to be the only drawback. If I take two I experience the euphoric feeling, but one usually does it for the pain for 2 to 3 hours. I have never had a nasty side effect from it either. The Phentynal makes me nauseated especially when it is hot and the Zanaflex give me dry mouth but that’s it. If I have learned anything when It comes to medication, it is that everyone reacts differently to it. What works for one might not do shit for another. I have heard a lot of negative comments about Nucynta from people, not very people like it.
 
if you are feeling euphoric from your normal dose of painkillers you are taking too much. might be hard to realize but will help you in the long run
 
I'm surprised there aren't more positive reports on this drug. I was quite taken with it at first.

Perhaps after it gains wider circulation, maybe?

I think the reason is because people who are already habituated on higher doses of opiates think it'll make them nod like their normal opiate dose does but it won't unless you add something with it (weed, somas with nucynta are fucking amazing, any other opiate with it is fucking amazing as well)

someone with no or liottle opiate tolerance could probably enjoy it alone, but an experienced user will not be particularly impressed with it unless it is combined with another opiate or muscle relaxant or both and of course weed.
 
Of course this doesn't take into account NA inhibition...

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affinity doesn't necessarily equate to pharmacological action...ie buprenorphine.
 
IV Talpentadol

Another update, meant only for HARM REDUCTION.

On three occasions (since my RSD has become much more erratic and less painful) I experimented with IV'ing this substance, the only logic behind it being that I knew my doctors wanted to cut down on my pain-meds, and that this was the final script. In doing this, I washed off the orange coating in distilled water, then crushed it in a sterilized spoon, and filtered it twice using multiple cottons. The product was maybe .3 mL of a clear liquid with only the faintest yellowish tint. I had a trusted friend actually do the IV, as he has a great deal of experience in that area, and after registering, everything went in smooth as could be (as though in a hospital).

Despite my reservations, I have to say that it was nearly the most enjoyable drug I have had IV (the others being generous shots of hydromorphone in the hospital, and one experience with VERY pure black tar) The rush is very gentle, not so much of a shock, and feels rather like a very large hydrocodone dose, with a moderately speedball-esque feeling, and a unique warmth which lasted about 2.5-3 hours, nodding for most of the time (dosage was around 150mg and later shots at 225mg) Also, its worth noting that one of the shots contained 5mg MDPV (pure), and that combination blew everything else away. However, this was not without some consequences.

As a warning, its probably not at all good for you to IV either drug. My friend very expertly hit and registered the vein every time, and yet I developed incredible bruises, about the size of a postage stamp per IV site, that expanded; turning from purple to shades of blue and green. For comparison, the bruising I got on the IV site for black tar,(in which I made multiple attempts to register) was slightly smaller than a tic-tac, and light purple.

As a (humorous or cautionary) aside, I was wrongfully searched and arrested two days later, for carrying my pills without all of the prescription copies :X (as well as possession of an oral syringe w/out needle, for plugging). Suffice to say the bruises on my arms did not help convince the cop that I was a chronic pain patient. Luckily all charges were dropped, after 2 months of assembling paperwork. :|

Moral of Story: The potential costs of IV Talpentadol do not equal the benefits
 
Hey guys, long time lurker first time posting.

I figured I'd share some insight on this drug, I've had about 3 prescriptions for it for dislocating my shoulder for the 6th time or so and I'm in constant pain.

It's a very weird drug. If I take 150mg+ I'll actually hallucinate vividly with closed eyes, open eyes its akin to a DPH hallucination, little dots running around and what not..

I get a lot of euphoria for about an hour and then it dissipates quickly, but I enjoy it. Sadly my co-pay is $50 for 30 pills and my Doctor is willing to prescribe since it has less abuse/addiction potential but that's just not true.

If anyone has any other questions I can answer them.
 
I get the same effect from tramadol once it is converted to odesmethyl and if I am on a high dose of benzos. i believe it is the mix of mu agonism with NMDA antagonism. I can literally see real life objects when I close my eyes and engage in conversations. I am also fully narcoticised, that is, I am laying on my bed and cannot move. Mind you this only happends with 150 mgs.

Bizarrely, medium doses of pregabalin (on its own) have the same effects.

I believe morphine is also considered to produce CEV's in high enough doses as do some other opiates.

Lol, these sort of things happen to me all the time on on tramadol too (thank God for my metabolism!), especially combined with Lyrica.

I remember once when I had taken 300 mg of tram, 1 mg of bupe and 300 mg pregabalin, I sat at my kitchen table making a sandwich and talking to my sister who sat on the chair opposite of mine. Just that she wasn't there, but she spoke to me and I couldn't bring myself not to answer her because I figured she'd think I was being an ass. But that's not the strangest part...what's really fucked up is that I don't even have a sister. Also I did not know who I was or where I were at that state. It wasn't huge doses of any of the substances either and at that time I had been using opiates for five years already so I did have a tolerance.

Many times I sort of "nod off" on tram too (not real opioid nod, more like a deliriant, dissasociate state and I've been using H and morph for some time so I know my way around nodding) and wake up talking to myself, saying random sentences which make no sense.

Since I do find tramadol a really interetsting chemical when I have low tolerance, I would really love to try out tapentadol but sadly my govt's drug policy is totally out of control and they've even scheduled tram (you have to be basically terminally ill to even get the lowest grade opioids prescribed, getting morphine or oxy legally here is practically unheard of) so it probably won't happen any time soon. Interesting thread, though!

And oh, first time poster here, as well (even though I've been lurking for years). Hi!
 
Oh my, yes...I mentioned this on another thread. On two occasions I mixed the two (say 450-600mg pregabalin and ~300mg tapentadol). The visuals caused by this combination induced were insane, to say the least. Fast moving CEV's conversations with invisible people, and OEV's that put me in an almost delirious state (one example would be seeing people carrying non-existent objects and demanding to have them, causing much confusion). :)

However, I don't think I could, in good faith, reccomend this combination to anyone (unless you want people to think you're truly nuts)

that sounds pretty cool, same thing happened to me with gaba weed and plain tramadol. been wanting to get my hands on some tapentadol for a while now.
 
My advice...stay the hell away from Nucynta. I have arthritis in my spine, degenerative disk disease and a blown disk at L5/S1 that is basically crushing my sciatic nerve 24/7 to varying degrees. I also have a wedge compression fracture at L1 and finally, about 6 months ago, after suffering from some very intense chronic pain for quite some time, I was diagnosed with Fibromyalgia. I have been on 20mg Oxycontin 3X/day and 20MG Oxycodone IR for breakthrough pain as needed but usually about 3-4 times a day. I have a very high tolerance for pain and those doses are not even close to being adequate but they make me almost comfortable so I live with it. For some reason my doctor decide he wanted me to try Nucynta. I suspect, from the chatter in the office and the discussion I had with the Pharmacist who is set up in the same office as my doc, the Rep for Nucynta had been around and was hammering them to write scripts. My insurance company would only cover it at 50% and I told my doc I couldn't afford it but he gave me a coupon for a 2 week free supply and pretty much forced it on me. Coupons for free meds and my doc forcing it on me makes a pretty clear picture, as far as I am concerned, about where the motivation came from. Anyway, I managed to get 5 doses of the 150mg CR into me, over 2.5 days and I can quite honestly tell you that this shit is one of the worst meds that has ever been pushed onto the market. Dose 1, 2 hours in and I have a maddening headache. No pain relief whatsoever, none, zero, zilch. Dose 2 and I'm off to bed. trying to sleep but can't because of the pain I am in. trying not to take my oxies because I want to establish what the Nucynta is doing. After an hour or so in bed I start experiencing muscle spasms in my legs. They are uncontrollable and I have never had this issue before. An hour later I am really tired and starting to nod but still experiencing the spasms. I guess that I fall asleep and I start experiencing lucid dreams. I feel that my left leg has gone completely numb but it is a dream. Dreaming the spasms as well. I wake up because of pain and realize that my left leg is in fact entirely numb. I try to get out of bed but I am in so much pain that it's a struggle. I finally manage it and after hobbling around a while the feeling starts to return to my left leg. Needless to say the night is fitful and the next time I wake it's because I am in fullblown withdrawal from my oxies. The nucynta is supposed to be an agonist just like the oxies so I am wtf? Bit of research reveals to me that even though Nucynta is an opioid agonist it won't prevent withdrawals from real opioids. Shorten the story at this point. 3 more doses with zero pain relief. I am now taking my oxy IRs to keep the pain somewhat down and the withdrawal at bay. I email my doc and tell him that I need to see him tout de suite... I discuss everything with him including how pissed I am that neither him nor the pharmacist knew this garbage wouldn't keep me out of withdrawal. He switches me back mto the same medication that I was on previously at the same doses.

Heres where the story just gets stupid...

Since going back on the Oxycontin/Oxycodone combination I can't get my blood serum levels up to the right point anymore and the pain relief levels that I was working with before are shot to hell. The NUcynta has done something to screw with my tolerance levels and now I'm needing at least twice my usual dose to get anywhere near the pain relief levels I was experiencing before trying Nucynta. I have tried oral, snorting and even hooped a dose trying to get my serum levels back into a happy place where I could just carry on with my old dose level and nothing is working. I am experiencing oxy withdrawal now at about 4 hours after my last dose. That's bloody insane. I could sleep for 10 hours before if my pain didn't wake me and then gut up and dose and only be mildly shaky. This is completely screwed up. I have to go and see my doc again and try and figure out what the hell to do. I'm thinking that a switch to controlled release and regular Dilaudid for 3 months or so might reset my tolerance for oxy and get me back on track. Or at least I hope that's what will happen.

In conclusion I will say that maybe NUcynta will work for somebody but in my case it was the worst possible thing that could have ever been given to me. Not only did it offer no pain relief but it has completely fucked my ability to take the meds that actually work for me. I guess someone with no tolerance could have some recreational fun with it but even that is a risk as far as I am concerned. I would just say to stay away from this garbage.
 
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Lol, these sort of things happen to me all the time on on tramadol too (thank God for my metabolism!), especially combined with Lyrica.

I remember once when I had taken 300 mg of tram, 1 mg of bupe and 300 mg pregabalin, I sat at my kitchen table making a sandwich and talking to my sister who sat on the chair opposite of mine. Just that she wasn't there, but she spoke to me and I couldn't bring myself not to answer her because I figured she'd think I was being an ass. But that's not the strangest part...what's really fucked up is that I don't even have a sister. Also I did not know who I was or where I were at that state. It wasn't huge doses of any of the substances either and at that time I had been using opiates for five years already so I did have a tolerance.

Many times I sort of "nod off" on tram too (not real opioid nod, more like a deliriant, dissasociate state and I've been using H and morph for some time so I know my way around nodding) and wake up talking to myself, saying random sentences which make no sense.

Since I do find tramadol a really interetsting chemical when I have low tolerance, I would really love to try out tapentadol but sadly my govt's drug policy is totally out of control and they've even scheduled tram (you have to be basically terminally ill to even get the lowest grade opioids prescribed, getting morphine or oxy legally here is practically unheard of) so it probably won't happen any time soon. Interesting thread, though!

And oh, first time poster here, as well (even though I've been lurking for years). Hi!

Dude, that EXACT same thing happened to me on Tapentadol (I am talking about the part where you woke up saying random sentences that mean nothing. I also have an INSANE tolerance for NMDA antagonists, where I may need 900mg of DXM, 250mg IM Ket to hole effectively, 200mg plugged MXE (over a few hours) to really enjoy the effects and experience OBE/ego-loss effects. So I don't think what happened had much to do with NMDA antagonism, and dissociatives don't usually cause those kind of effects anyway)
But anyway, what happened to me is I had experimented with 50mg Tapentadols at doses at around 150mg (which would cause me to have CEVs of what my room LOOKED like (and I could even navigate using this CEV, and I literally thought I had my eyes open looking in my room! This sort of thing DOES happen A LOT on DXM and is very common, so there may be some NMDA antagonism at play there, but it seems weird to be exhibiting those effects on me as my NMDA antagonist tolerance is insane as I aforementioned.

Then one day I took 450mg of tapentadol over a long period of time during the day, and then after that I drank about 5 shots of liquor in one gulp.. (At least, don't know how much was left, I was just so inhibited it went down like water) So apparently I pass out in the shower, my girlfriend finds me after an hour, and I am KNOCKED out COLD. They CANNOT wake me up. They call an ambulance, and apparently they stuck a needle in my knee to get a reaction, but to no avail. I woke up in a hospital many hours later and apparently made suicidal threads while unconscious.. WTF?! Then I started coming to, and I would start talking to my GF and would then nod out without realizing and splurt out RANDOM NONESENSE, i.e, "there are clowns around the space as I run around and see it going away" But it KEPT on happening for a few hours. I was SEVERELY delirious. I wonder if this has any anticholinergic action, as it sure felt like it! Very weird drug, but very euphoric, it does deserve a Sch2
 
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