Nucynta is the brand name and it came to the US market less than a month ago 6/22/09. I have read all the studies and it sounds like a great new innovative pain med. Has anyone personally used Nucynta? It does not bind to the mu opiod receptors as strong as morphine but the efficacy is equivalent to that over oxycodone 10mg. I am curious about the euphoria and the effect the dual mechanism of action has on it. Any info would be greatly appreciated.
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N&PD Moderators: Skorpio | someguyontheinternet
Has anyone had personal experience with Nucynta/Tapentadol
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Hammilton
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You're asking less than a month after it hit the market, what do you think?
I never tried it myself, though I did consider it while it was unscheduled.
Fortunately, though, we're free to look at analogues of tramadol still. Tapentadol may be derived from tramadol but tapentadol is not a tramadol analogue. Things like Ciramadol may be the way to go.
I never tried it myself, though I did consider it while it was unscheduled.
Fortunately, though, we're free to look at analogues of tramadol still. Tapentadol may be derived from tramadol but tapentadol is not a tramadol analogue. Things like Ciramadol may be the way to go.
timmaahh12
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Well, my brother-in-law just called to ask me what Nucynta was b/c his Dr. just prescribed him some. He said he needed something stronger than 7.5s b/c they weren't working (oh yeah, there is nothing wrong with this dude, he's as healthy as an ox) and that's what he gave him...so he said to stop by when i get off and get a few and try em out. So I guess i'll let ya'll know my opinion of them tomorrow... Oh, and he said that his dr. told him to only take a half and they're the 50mg pills. well, we'll see. i'll post results tomorrow...
tearsofaclown
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Well Tim, I hope you have some results to post. I am scheduled to get Nucynta in two weeks. I have no idea what it's like. Can you please let us know asap! Thanks so much.
tearsofaclown
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Hello? How did it go? Need to know this!
Yeah, but if you liked it better than tramadol, that at least has to go down as an improvement.
Somebody needs to keep harassing the FDA or DEA whoever it is to get it made into a sched III.
They should just make it completely OTC in fact, or at least no more dificult to buy than tramy.
They should just have promotional blister packs of the stuff that they put into childrens cereal packets like candy.
Somebody needs to keep harassing the FDA or DEA whoever it is to get it made into a sched III.
They should just make it completely OTC in fact, or at least no more dificult to buy than tramy.
They should just have promotional blister packs of the stuff that they put into childrens cereal packets like candy.
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Dankycodone
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I am interested to try it since I like tramadol.
Of course this doesn't take into account NA inhibition...
Hammilton
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How hard have you been searching? You can find numbers for all those things super easy (NOP is a little harder to find, admittedly, but that's changing too). Many of them don't even require journal access. If you want a chart pre-made, you're best looking in textbooks, I think.
edit: oops for some reason I thought it was .09nM KOR affinity.
edit: oops for some reason I thought it was .09nM KOR affinity.
I had an incomplete table at one stage, but I'm not sure what I did with it....
The information is out there; SWIM (literally, someone who isn't me) should compile a comprehensive table...
The information is out there; SWIM (literally, someone who isn't me) should compile a comprehensive table...
My doctor had mentioned this medication to me as an alternate to percocet.
I have been in severe debilitating chronic pain for 9 years, especially the past 5 after having some sort of reaction to duragesic patches (fentanyl). I havent worked since.
I was taking hydrocodone 60 mg daily supplemented with 15 mg morphine sulphate. Then I had a doctor fiasco, and am now down to 4, 10 mg percocet, daily, I got worse last year after having a reaction to intravenous fentanyl, given during a surgical examination. I told them Iwas allergic (Even though I have yet to "identify" what the medication is actually doing to me to cause me pain.
This stuff sounds interesting but I have taken ultram with hydrocodone and had little if any benefit from the ultram, I also had side effects from cymbalta, and terrifying withdrawal from the drug, (I had to pour out of the lowest prescription capsules to taper off without symptoms, scary stuff, and not something I want to repeat with this drug if it is that similar.
I have been in severe debilitating chronic pain for 9 years, especially the past 5 after having some sort of reaction to duragesic patches (fentanyl). I havent worked since.
I was taking hydrocodone 60 mg daily supplemented with 15 mg morphine sulphate. Then I had a doctor fiasco, and am now down to 4, 10 mg percocet, daily, I got worse last year after having a reaction to intravenous fentanyl, given during a surgical examination. I told them Iwas allergic (Even though I have yet to "identify" what the medication is actually doing to me to cause me pain.
This stuff sounds interesting but I have taken ultram with hydrocodone and had little if any benefit from the ultram, I also had side effects from cymbalta, and terrifying withdrawal from the drug, (I had to pour out of the lowest prescription capsules to taper off without symptoms, scary stuff, and not something I want to repeat with this drug if it is that similar.
bicycle-ride1943
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Summary and experience with Nucynta
After being on Tramadol and then Perc 5/500 x3 for back pain switched to Nucynta 75mg x3 a day. Coming out of the office never heard of it so I took one to see how it would effect me. An hour later took another because no relief had been felt. Well that was a mistake because come to find out 150mg of this stuff is very strong. Since then Ive been on the 50's, 75's and 100's all at varying frequencies. Ive landed on the 75mg x4 a day. Pain relief lasts 4 hours, maybe 6 if Im lucky.
For me, It starts working in about 35-45 minutes after ingestion and it seems that it works more effectively on an empty stomach with food eaten 1-2 hours after ingestion. Theres is noticeably less tolerance compared to Oxycodone or Hydrocodone in my experience, although this stuff is still addicting; mainly psychologically. During periods of decreasing dose or or 4+ hours after primary effects wear off I've encountered agitation, depression, and increase in anxiety (basically dysphoria). As far as physical side effects go, I have occasional muscle twitching(tolerable) almost always in my hand/fingers, occasional sweating, and sometimes an increased heart rate. I've encountered the physical side effects In the middle of a dose up to about 1-2 hrs after the primary effects have gone. Note that the aforementioned effects during cessation of use worsen depending on how high of a dose you've been taking, as well as how often it's being taken.
For all those saying Nucynta is Tramadol on steroids is wrong from what Ive encountered. The effect/feeling of Nucynta isn't really comparable to any of the other opioids. As far as the people on here wondering about the "positive side effects"I've encountered euphoria, increased talkativeness, increased motivation, and increased appreciation of music, all of which last primarily for 2 hours (beginning at the 35-45min after ingestion). Do not try to swallow a Nucynta without fluids, they don't go down well without water and it burns your esophagus like hell If it gets lodged.
My concerns of this medication are as follows.
- Nucynta's clinical trials lasted about a year from what I've read, leaving me worried about possible long term effcets or recalls down the road
- Nucynta is the only new drug in the centrally-acting analgesic class to be approved by the FDA in over 25 years. This means big money for the manufacturer. Problems with backdoor kickbacks?(ex.- Doctors receiving research funding or publicity for publications in return for prescribing a certain medication) I've encountered some things In my four months of being on Nucynta that only fuel this suspicion.
- A comprehensive database hasn't been created to record drug-drug interactions, again due to this being a new medication(released on the market June of 2009)
- No CVS or Walgreens within a 15 mile radius had the 75mg tabs stocked and didn't have any on order. I have to drive 21 miles to the pharmacy that is part of the pain management facility to get Nucynta... very inconveniant. I'm on BWC, so I don't know how much it costs with or without insurance but I'm sure it's quite a bit.
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doublelifed
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I was prescribed nucynta for back pain after a fusion. The first one I took(orally) gave me a great feeling, but as with most drugs I have yet to achieve that feeling again. The potential for abuse of nuycnta is high, I would compare it with oxycontin, but not as strong. If you don't mind the bruises, its considerably good. But at the rate you'll go thru your supply and it only lasts for 15 min., its not really worth it. Totally worth a test drive though! As for pain relief they take up to 1 1/2 hours to kick in, and I was told they were for breakthough pain. Me personally, I like to suck the coating off and swallow them. Next month when I see my doc I will probably ask to go to lortab or percocet...at least I know what those are and what to expect from them. Also one of the side effects I've had is night sweats so every morning I wake up freezing cold.
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bicycle-ride1943
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The night sweats are just an unfortunate side effect which is listed on their website as well as on the literature that comes with the script. Dudes experienced this as well.
Usually notice they take effect within 45-60 minutes, probably peaking around 1-1.5 hrs as stated above. The euphoric side effect typically lasts about 1-3 hrs, but that is totally dependent on tolerance, doseage, and the individuals metabolism. Noticed Nucynta isn't very sedating unless more than 150mg+ is taken at once at least for a male that is 150lbs with a very high metabolism. Usually one gets very talkative and motivated to go do things and talk to people, unlike hydrocodone or oxycodone which typically make people want to sit around and play video games or things of that nature. No noticeable itch on Nucynta. Agreeing with the above post on Nucynta's addictive nature. Compared to a multitude of other substances that one never deemed addictive Nucynta cravings are pretty strong, although at first the effects didn't seem very desireable after the body becomes accustomed to it the effects actually change. This is why many people probably report not liking Nucynta upon trying it because they take a crazy high dose the first couple times which isn't going to give a good feeling. Let your body get used to it, almost like you're weening yourself onto it. It is important to only take the amount allotted by your doctor as to not get addicted. Also, think rationally when asking for your doc to up your dose- you have to ask yourself "do I really need a higher dose/more frequency per day for pain or would it just be nice and/or convenient to have whenever I want. When it comes down to it Nucynta is the only thing that completely alleviates said chronic back pain. Said guy built an initial tolerance but now that hes been on a 75mg dose a 4x day for 5 months, no noticeable continual or building tolerance to the drug, which is pretty amazing. On something like oxycodone ( prior med treatment) after a week or two would go by the dose would have to be upped to achieve not the the same pain killing effect.
Recently noticed that the period of pain relief has gotten shorter, where it used to alleviate from anywhere between 4-6hrs its more like 2 MAYBE 3hrs. In the morning sometimes the first dose doesn't do anything. The instructions say if relief is not felt within the first hour another dose may be administered. That is a problem when one is waking up at 4am for manual labor work and having 2 of 4 doses gone for the day by 6am when not getting to sleep till 9-10pm due to school.
Usually notice they take effect within 45-60 minutes, probably peaking around 1-1.5 hrs as stated above. The euphoric side effect typically lasts about 1-3 hrs, but that is totally dependent on tolerance, doseage, and the individuals metabolism. Noticed Nucynta isn't very sedating unless more than 150mg+ is taken at once at least for a male that is 150lbs with a very high metabolism. Usually one gets very talkative and motivated to go do things and talk to people, unlike hydrocodone or oxycodone which typically make people want to sit around and play video games or things of that nature. No noticeable itch on Nucynta. Agreeing with the above post on Nucynta's addictive nature. Compared to a multitude of other substances that one never deemed addictive Nucynta cravings are pretty strong, although at first the effects didn't seem very desireable after the body becomes accustomed to it the effects actually change. This is why many people probably report not liking Nucynta upon trying it because they take a crazy high dose the first couple times which isn't going to give a good feeling. Let your body get used to it, almost like you're weening yourself onto it. It is important to only take the amount allotted by your doctor as to not get addicted. Also, think rationally when asking for your doc to up your dose- you have to ask yourself "do I really need a higher dose/more frequency per day for pain or would it just be nice and/or convenient to have whenever I want. When it comes down to it Nucynta is the only thing that completely alleviates said chronic back pain. Said guy built an initial tolerance but now that hes been on a 75mg dose a 4x day for 5 months, no noticeable continual or building tolerance to the drug, which is pretty amazing. On something like oxycodone ( prior med treatment) after a week or two would go by the dose would have to be upped to achieve not the the same pain killing effect.
Recently noticed that the period of pain relief has gotten shorter, where it used to alleviate from anywhere between 4-6hrs its more like 2 MAYBE 3hrs. In the morning sometimes the first dose doesn't do anything. The instructions say if relief is not felt within the first hour another dose may be administered. That is a problem when one is waking up at 4am for manual labor work and having 2 of 4 doses gone for the day by 6am when not getting to sleep till 9-10pm due to school.
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I am very, very new here, so maybe some things I don't understand, someone else could clarify for me)
This won't be as long or informative as some other posts, but since I have some experience, I will report what I do notice. My first complaint is that while I generally tolerate pain meds well, this tends to make my stomach slightly unhappy. Occasionally with Vicodin or Darvocet, after a few days I would get a little bound up. The Nucynta doesn't do that, it just makes it feel a little sour. The prescription order is actually to take one Nucynta with one Ultram, but Ultram upsets my tummy a little too, so I imagine the combination would be one I don't intend to try.
If I take a high dose of Nucynta, I can definitely feel it. Kind of like everything's OK in the world. I have one major disappointment that maybe someone can help me out with. If I pop a few Vicodin or Darvocet, I get the euphoria AND turn into Wonder Woman...as in I am the most efficient housewife ever (no kids, but I don't work). I buzz around the house organizing everything, moving furniture and cleaning behind it, and my house ends up looking like it could be on the cover of Better Homes & Gardens. Nucynta feels good enough, I mean it's worth taking, but I so wanted the other part. Maybe tomorrow I'll try some Nucynta and Red Bull. Just wondered if anyone had any insight. Thanks!
This won't be as long or informative as some other posts, but since I have some experience, I will report what I do notice. My first complaint is that while I generally tolerate pain meds well, this tends to make my stomach slightly unhappy. Occasionally with Vicodin or Darvocet, after a few days I would get a little bound up. The Nucynta doesn't do that, it just makes it feel a little sour. The prescription order is actually to take one Nucynta with one Ultram, but Ultram upsets my tummy a little too, so I imagine the combination would be one I don't intend to try.
If I take a high dose of Nucynta, I can definitely feel it. Kind of like everything's OK in the world. I have one major disappointment that maybe someone can help me out with. If I pop a few Vicodin or Darvocet, I get the euphoria AND turn into Wonder Woman...as in I am the most efficient housewife ever (no kids, but I don't work). I buzz around the house organizing everything, moving furniture and cleaning behind it, and my house ends up looking like it could be on the cover of Better Homes & Gardens. Nucynta feels good enough, I mean it's worth taking, but I so wanted the other part. Maybe tomorrow I'll try some Nucynta and Red Bull. Just wondered if anyone had any insight. Thanks!
bicycle-ride1943
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Yes Nucynta does have a sort of stimulant effect. I'm prescribed Adderall for ADHD & the Nucynta for my back... I laughed when I read the part where you said you turned into Super Woman lol. I told my buddy I was Super Man referring to the same thing a couple weeks ago. Be careful mixing other pain meds with Nucynta though. It has just now been on the market for a year and I'm sure they havn't studied the effects when combined with something else very in depth.
LoveAndTheft
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Initial Thoughts Concerning Tapentadol
I began my first Nucynta experience with the intent to preserve my remaining 1/2 dozen tablets of Dilaudid. I have heard or read several testimonies about this relatively new (13 mos. old) drug. Opinions covered all aspects of various reactions. 1X 100mg @ 5:36PM
5:36PM - Ingestion w/10 oz. of water & generic Claritin tablet.
5:59PM - Possibly feeling first effects.
6:05PM - Definitely feeling warm inside.
6:08PM - Listening to Sacred Sound Alchemy for DNA Repair & Healing. Very enjoyable so far (meds & music).
6:20PM - Slight stomach discomfort.
6:23PM - Mild anxiety from either Dilaudid withdrawal or nicotine withdrawal; riding euphoric waves, possibly nodding off.
6:37PM - Definitely nodding, heavily. Stomach condition - same or better, but not worse.
6:45PM - Wow, it takes all I have to speak; feeling great.
7:08PM - Computer monitor seems as though it's moving slowly from side to side. Had a 12 oz. Mt. Dew.
7:37PM - Nod seems to be gone, but waiting to find out; pain relief is still present.
7:58PM - Still enduring a slight nod. I am going to lie down for an hour or so.
9:22PM - I didn't sleep, but rested for 1 hour. I made a trip to the store for 2 24 oz. beers & a chocolate bar. Pain relief is still in effect, but the buzz is gone.
9:53PM - After having held out all day, I resorted to one of my Dilaudid tablets.
11:00PM - Purchased a Garcia y Vega cigarillo.
11:45PM - Cut last remaining 100mg Nucynta in half. Ingested both halves with approx. 2.5 oz. of beer.
11:47PM - Here's hope to a friend's wife coming through with promised handful of 10/650 Hydrocodone...I've heard stories for days now...hopefully this doesn't turn into a lesson learned, even though I already feel like it has. Monday has been the latest promised date...we'll see.
12:21AM - Once again, beginning to feel Nucynta's short lived yet beautiful buzz from just second dose ever of 100mg Nucynta. Keep in mind the Molson Ice beer & 2mg dose of Dilaudid.
12:28AM - Feeling 'heady' from Nucynta. Comparable, just slightly, to what Dilaudid does for me.
12:38AM - I really don't like the feelings of anxiety while on Nucntya. Proceeding downstairs to finish off aformentioned cigarillo.
12:44AM - Thankfully, the anxiety has come and gone in a matter of minutes.
12:46AM - I am nodding...like, one eye open to view my computer's monitor nodding. The temperature is 66 degrees F. I'm having a hard time keeping my eyes open. I'm beginning to hear voices, but there's noone around.
1:07AM - I'm sure the euphoric waves I experienced the first time around have come and gone. I felt another nod while finishing my cigar, but that was the end of the beautiful buzz.
My conclusion is that Nucynta is a great pain reliever, but as for it's recreational properties, well they are few and far between. Like I stated earlier, it's only slightly comparable to Vicodin, Percocet or Diluadid. I prefer Diluadid by far. I can't say that I will use it (Nucynta) again, but what the future holds is a whole different story altogether.
I am going to retire for the evening. The usual is in store for me. Prayer, scripture reading and then lights out.
Please, always remember this. Good God, good luck, Amen.
I began my first Nucynta experience with the intent to preserve my remaining 1/2 dozen tablets of Dilaudid. I have heard or read several testimonies about this relatively new (13 mos. old) drug. Opinions covered all aspects of various reactions. 1X 100mg @ 5:36PM
5:36PM - Ingestion w/10 oz. of water & generic Claritin tablet.
5:59PM - Possibly feeling first effects.
6:05PM - Definitely feeling warm inside.
6:08PM - Listening to Sacred Sound Alchemy for DNA Repair & Healing. Very enjoyable so far (meds & music).
6:20PM - Slight stomach discomfort.
6:23PM - Mild anxiety from either Dilaudid withdrawal or nicotine withdrawal; riding euphoric waves, possibly nodding off.
6:37PM - Definitely nodding, heavily. Stomach condition - same or better, but not worse.
6:45PM - Wow, it takes all I have to speak; feeling great.
7:08PM - Computer monitor seems as though it's moving slowly from side to side. Had a 12 oz. Mt. Dew.
7:37PM - Nod seems to be gone, but waiting to find out; pain relief is still present.
7:58PM - Still enduring a slight nod. I am going to lie down for an hour or so.
9:22PM - I didn't sleep, but rested for 1 hour. I made a trip to the store for 2 24 oz. beers & a chocolate bar. Pain relief is still in effect, but the buzz is gone.
9:53PM - After having held out all day, I resorted to one of my Dilaudid tablets.
11:00PM - Purchased a Garcia y Vega cigarillo.
11:45PM - Cut last remaining 100mg Nucynta in half. Ingested both halves with approx. 2.5 oz. of beer.
11:47PM - Here's hope to a friend's wife coming through with promised handful of 10/650 Hydrocodone...I've heard stories for days now...hopefully this doesn't turn into a lesson learned, even though I already feel like it has. Monday has been the latest promised date...we'll see.
12:21AM - Once again, beginning to feel Nucynta's short lived yet beautiful buzz from just second dose ever of 100mg Nucynta. Keep in mind the Molson Ice beer & 2mg dose of Dilaudid.
12:28AM - Feeling 'heady' from Nucynta. Comparable, just slightly, to what Dilaudid does for me.
12:38AM - I really don't like the feelings of anxiety while on Nucntya. Proceeding downstairs to finish off aformentioned cigarillo.
12:44AM - Thankfully, the anxiety has come and gone in a matter of minutes.
12:46AM - I am nodding...like, one eye open to view my computer's monitor nodding. The temperature is 66 degrees F. I'm having a hard time keeping my eyes open. I'm beginning to hear voices, but there's noone around.
1:07AM - I'm sure the euphoric waves I experienced the first time around have come and gone. I felt another nod while finishing my cigar, but that was the end of the beautiful buzz.
My conclusion is that Nucynta is a great pain reliever, but as for it's recreational properties, well they are few and far between. Like I stated earlier, it's only slightly comparable to Vicodin, Percocet or Diluadid. I prefer Diluadid by far. I can't say that I will use it (Nucynta) again, but what the future holds is a whole different story altogether.
I am going to retire for the evening. The usual is in store for me. Prayer, scripture reading and then lights out.
Please, always remember this. Good God, good luck, Amen.