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  • BDD Moderators: Keif’ Richards

Has anyone ever successfully reset their drug tolerance

M

muffychuffy

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Joined
Jul 13, 2023
Messages
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It doesn't matter how long of a break I take, or if I add dxm and whatnot, tolerance always feels inevitable. I cannot escape it. I was using 80mg of vyvanse over the course of 12 hours in 2022 and no matter what I do I can't seem to respond to stimulants well anymore beyond the first couple days. It mostly just feels like cool lucid focus for a couple hours and then pure anxiety for the test. I'm afraid I've sabotaged myself with how I was using. Typically on a given day I took 40mg in the morning followed by 2mg doses sprinkled throughout the day along with one 20mg dose. Has anyone returned to thereaupeautic use of stimulants successfully?
 
muffychuffy said:
It doesn't matter how long of a break I take, or if I add dxm and whatnot, tolerance always feels inevitable. I cannot escape it. I was using 80mg of vyvanse over the course of 12 hours in 2022 and no matter what I do I can't seem to respond to stimulants well anymore beyond the first couple days. It mostly just feels like cool lucid focus for a couple hours and then pure anxiety for the test. I'm afraid I've sabotaged myself with how I was using. Typically on a given day I took 40mg in the morning followed by 2mg doses sprinkled throughout the day along with one 20mg dose. Has anyone returned to thereaupeautic use of stimulants successfully?
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As far as I know 80mg is still in the therapeutic dose range. My son was on 90mg at one point, 70mg in the am and 20mg at lunch.
I think what you're experiencing is normal as far as your tolerance. You'd probably have to switch to another med for a while to get the most benefit. I understand that you were taking a higher dose, but meds can lose efficacy after a period of time. I am just going to assume this is a prescription that you measured out and took throughout the day. You need to get back to your normal dose so you aren't going half the month without. I would talk to your Dr about:
1. Increasing your initial dose (they go to 70mg)
2. Adding a different med around lunchtime (10mg IR Adderall or something similar)
3. Do not take anything on your days off. If you don't have school/work, take the day off meds.
 
So it's normal for the speedy effect of speed to go away after only a few doses? That wasn't my experience in the past. Usually I would get 4 hours of focus and then a crash but the window pf focus is just so much lower now. I'm wondering if my sporadic use of the vyvanse throughout the day fucked things up
 
There's a few things that can help to "reset" tolerances. The main ones are agmatine and theanine, both are otc.
Some people use memantine (also an NMDA antagonist).
 
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Allylbenzene said:
There's a few things that can help to "reset" tolerances. The main ones are agmatine and theanine, both are otc.
Some people use memantine (also an NMDA antagonist).

One of the most underrated ways is to reduce the baseline level of stimulating neurotransmitters. The main ones are:
- adrenaline
- glutamate

These come from stress, so anti-stress strategies will help, as well as drugs that are anti-glutamate and anti-adrenaline.
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But you can take agamatine and theanine while amphetamines or you have to stop stims to reset tolerance??

Thanks in advance!!
 
I think keeping tolerance down has been, in effect, my life's work (I have done other things too...but it's definitely been an ongoing theme!)

I've managed pretty well too - moderation (definitely always managed that one, ahem), rotation and breaks are key (who knew??). Let's leave stimulants out of this though, because there is an entirely different narrative surrounding those..

I can still get really high on, say, 300mg nice weed smoked, 50mg of a good concentrate (dabbed), 30mg thc (eaten). Not bad after around 4 decades of use, probably averaging 5 days use per week (maybe 6, dunno - it's been more like 13 days a fortnight for last couple of years, but that one day off is crucial re tolerance, as is rotating different forms of cannabis and having some very low dose days too, sometimes just a single-skinner blunt or a small dab around 8pm)

Can also still get a nice high (and good analgesia) out of 100mg opium latex, or 20mg Morphine, 10mg Oxycodone (sometimes a noticably pleasant high off 5mg even), and that's after 17 or so years of on/off use. I know that's unusual and I've been fortunate with that - but I have followed a pretty strict dosing schedule, stuck to my boundaries and held myself accountable. Am pretty sure it would have been a different story if had started with opiates earlier in life.

Looking forward to being asked what I did with my life at the pearly gates...is it St.Peter who conducts the interrogation?

"Next please. Ah, Mr Fiend...now can you tell me your greatest achievements in life please?" ...

"Well, I did manage to keep my tolerance to some drugs down to a reasonably low level...so there's that"
 
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ageingpartyfiend said:
Let's leave stimulants out of this though, because there is an entirely different narrative surrounding those..
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I would say that most natural stimulants can be used sustainably long-term, including betel, cacao, kola nut, coca leaf, khat, hordenine (barley) and coffee (caffeine is a metabolic stimulant unlike conventional stimulants). The issue is with synthetic stimulants like (meth)amphetamine which require some forethought to keep tolerances low.
 
muffychuffy said:
It doesn't matter how long of a break I take, or if I add dxm and whatnot, tolerance always feels inevitable. I cannot escape it. I was using 80mg of vyvanse over the course of 12 hours in 2022 and no matter what I do I can't seem to respond to stimulants well anymore beyond the first couple days. It mostly just feels like cool lucid focus for a couple hours and then pure anxiety for the test. I'm afraid I've sabotaged myself with how I was using. Typically on a given day I took 40mg in the morning followed by 2mg doses sprinkled throughout the day along with one 20mg dose. Has anyone returned to thereaupeautic use of stimulants successfully?
Click to expand...
Vyvanse specifically I haven’t really ever taken it habitually but found the window/threshold beyond 70-90 to almost be pointless. I haven’t checked in years but the bioavailability window kind of checks out around that dose so even if you took more I feel like the anxiety aspect would just kick your ass. If that’s the only amphetamine your doing you might want to just keep it that way and try and space your doses out bug still taking a higher one initially. That’s what worked for me but I’ve always been an addy IR kind of guy.
 
Has anyone ever successfully reset their drug tolerance


For the last 6 and a half years. Yes.

Ween.
 
muffychuffy said:
It doesn't matter how long of a break I take, or if I add dxm and whatnot, tolerance always feels inevitable. I cannot escape it. I was using 80mg of vyvanse over the course of 12 hours in 2022 and no matter what I do I can't seem to respond to stimulants well anymore beyond the first couple days. It mostly just feels like cool lucid focus for a couple hours and then pure anxiety for the test. I'm afraid I've sabotaged myself with how I was using. Typically on a given day I took 40mg in the morning followed by 2mg doses sprinkled throughout the day along with one 20mg dose. Has anyone returned to thereaupeautic use of stimulants successfully?
Click to expand...
You used to do drugs to make other things more fun, then you started doing other things to make the drugs fun. That's why you can't revisit those amazing highs, and you won't be able to until you can get back to being a normal standard-issue human again that can simply enjoy life.

The double-whammy of an exciting adventure and an amazing buzz results in those memorable, breathtaking memories you're chasing.
 
Suboxone said:
You used to do drugs to make other things more fun, then you started doing other things to make the drugs fun. That's why you can't revisit those amazing highs, and you won't be able to until you can get back to being a normal standard-issue human again that can simply enjoy life.

The double-whammy of an exciting adventure and an amazing buzz results in those memorable, breathtaking memories you're chasing.
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That really resonated with me. I've been in a complete hole for 3 years. Are you saying the stims may work again if I ever do get out of this hole?
 
muffychuffy said:
That really resonated with me. I've been in a complete hole for 3 years. Are you saying the stims may work again if I ever do get out of this hole?
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If you cure your depression? Sure. The drugs are what are causing the depression though, so you'll need to quit them for a time and let your brain reset. Then work on enjoying life and AFTER all of that enhance that enjoyment with some drugs. You may find you don't need or want the drugs anymore once you aren't a depressed ball of suicidal ideation and anxiety.

First you need to accept that the drugs are making you anxious and depressed, because they absolutely are, and be willing to separate yourself from the drugs to let your brain and mind heal for a time.

And I just accidentally walked you through step 1 of AA. Am I your sponsor? ❤️
 
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My drug tolerance is already reset...last joint was this summer-once only after most of year absence-hits me hard..20 days without pods or any Opies(got one day some codeine only)-guessjust a few pods would hit me hard if I got..benzos-two weeks without except one day....it was just 5mg diazepam and for first time in 10 years I truly can say I feel it like some noobie to benzos....so after some absent from drugs tolerance resets.it's normal
 
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