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Grapefruit Juice, Question?

TheDEA.org said:
<inhale>

Grapefruit juice is not an effective potentiator of MDMA


Now, for the 0.0001% of humanity that's actually interested in how such things work:

1. The enzyme (actually a group of functionally similar enzymes called an isozyme) that is inhibited by a chemical found in some grapefruit juice is called CYP 3A4.

2. CYP 3A4 turns slowly turns a small amount of MDMA into MDA, a more potent drug. It may also eventually convert MDA into a less inert metabolite, but I'm not aware of any research exploring that possibility.

Since the conversion process is slow, the amount converted is small (perhaps 10% over the 8-9 hour half-life of the drug), and at least the immediate conversion product is actually more potent than the original MDMA molecule, inhibiting 3A4 will at absolute best only have a trivial potentiating effect, and may even (again, trivially) reduce the strength of the experience by interfering with the production of the more potent MDA.


To top it all off, declining levels of MDMA in your body aren't the sole reason you 'come down'. That ~9 hour half-life means that if you take 2 pills, you'll still have 1.5 pills worth of MDMA in your system 4.5 hours later. But it sure doesn't feel like it, does it? There are at least two reasons for this. First, levels of serotonin (and perhaps other neurotransmitters) have probably been depleted; your brain is in a manner of speaking 'running out of gas'. Another important factor is tolerance; if there's a lot of (for instance) serotonin floating around your synapses (caused by MDMA releasing it), your brain cells will actually hide/deactivate serotonin receptors in order to try to 'tune out' the unusually strong signal.

That's why you can't stay high on MDMA indefinitely, why if you just keep taking more pills you still can't maintain that warm happy high.
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well fuckin said buddy
 
ControlFreak said:
I'm Actually talking about pure MDMA, Not pills, and yes I do in fact preload myself religiously, to get the most out of what MDMA experince is, I do not waste myself, in trying to act like a fool, like some of you that go on Binges of rolling for days, that for me is stupid, I believe that only certain people are allowed to really apretiate MDMA, and to understand its true Utopia, I a world that does not make sense anymore, We think We are in Control, but we are not. MDMA Makes us Understand behound our daily lifes, makes us stronger mentally, and makes us more relaxed , more easy going people, understanding the facts an importances of differences of people.


MDMA is only for a few that believe in a world of Utopia and take the message of MDMA and spread it to the world.

I believe one day this hard asses will all die and the world will be a better place with Brilliant minds, with People that all believe in Unity and Peace and Love.


Peace
Dance4Life
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Dam ran across this and had to say great post!!!!!!!! "Toke the words out of my mind that I cant put in words"
 
I suggest consuming the grapefruit several hours prior to doing it and allow it to work its magic.. and I've heard squeezing fresh grapefruit juice works better than grapefruit juice.
 
ControlFreak said:
I believe that only certain people are allowed to really apretiate MDMA, and to understand its true Utopia... MDMA Makes us Understand behound our daily lifes, makes us stronger mentally, and makes us more relaxed , more easy going people, understanding the facts an importances of differences of people.
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i agree. but before we get too mystical, let's remove the plastic buddha figurines from our asses. makind has always used mind-altering substances for various shamanic purposes. but it's not required. you can ascend/ transcend/ become enlightened without the aid of any chemical/substance.

MDMA is heavenly. but after the come down, we still must navigate complex human emotions. life is the sum of both beauty and pain. your utopia will crumble after a few dozen rolls. let the drug teach and inspire. but respect its limitations. i don't think we need to build religions around it...
 
clippper said:
I suggest consuming the grapefruit several hours prior to doing it and allow it to work its magic.. and I've heard squeezing fresh grapefruit juice works better than grapefruit juice.
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...

IT DOESN'T WORK! HAVEN'T YOU BEEN PAYING ATTENTION?

:D
 
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