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Grapefruit Juice, Question?

ControlFreak

ControlFreak

Bluelighter
Joined
Jul 30, 2006
Messages
401
Location
UK
Ok I have searched Bluelight for tips on Preloading before Inducing MDMA.


And it Says Grapefruit Juice has an Enzyme that breaks Down MDMA, and I guess the more Grape Fruit Juice you drink the more of this Enzyme you have to break down MDMA and the more MDMA retention you can get.


But I also read that the more acidic you have in your stomach that any MDMA will be lost and not get absorbed thats why alcaline or less acidic stomach will get a better come up on MDMA.

and Grape fruit Juice is Acidic Vitamin C, so my question is that is contradicting itself.

is anyone ever preloaded with grapefruit juice and 5 -htp and did you notice a big difference on the way you Roll, is it more intense, or was about the same?


Peace
Dance4Life

"IF WE CANNOT END OUR DIFFERENCES, AT LEAST
WE CAN HELP MAKE THE WORLD SAFE FOR DIVERSITY"
-JOHN F KENNEDY
 
No. grapefruit juice inhibits an enzyme that breaks down mdma. So your body can use more of what you put in it.
However I don't think the effect is great enough to be useful.
 
I advise against pre-loading with 5-htp as it is a precursor to serotonin. Mdma depletes serotonin and 5-htp helps to replenish it, the two drugs are contradicting. 5-htp can mute the effects of mdma and possibly cause serotonin syndrome.

It is good to take 5-htp a few days before you take mdma and for a few days afterward, but do not take it in a pre-load regimen.
 
ok purplefirefly

So you say within a week before I induce mdma

I should stop taking 5-htp

I usually been taking now 200 mg everyday since New Years.

and I'm Planing rolling in about 2 months.
 
Mate, seriously...........just take your pills...........there is NO magical thing you can take or do that will potentiate the pills abilities in any serious manner.

If there was then we would all be doing it every weekend.

Yes you may get a placebo effect or if your really really really lucky then a 1% increase............but chances are thats only gunna be a placebo to so save your energy.
 
I see a lot of people using Vicks vaporisers to heighten the high, never tried myself.

Beer usually gets me just a little notch more peaking, and a fuckload more dehydrated :P
 
MazDan said:
Mate, seriously...........just take your pills............
Click to expand...

Spot on! Yes GF juice will potentiate because it inhibits the cytocrome series of enzymes that matobolize MDMA but most anecdotal reports deny any significant subjective increase in effects but duration is probable. However be prepared for the neurotoxic effects to be greater. This is the same reason why opiates and MDMA are not a good combo, the cytochrome enzymes are tied up so your blood plasma levels contain more MDMA. This inhibition also increases the risks of overdose on MDMA or serious complications from interations because your bodies natural mechanism to rid itself of foriegn drugs is ihibited.

BTW, daily regimines of 5htp are not great for your cardiovascular system, look it up. Just live healthy, take normal multibitamins, stay hydrated, and most importantly eat before you crash and ASAP upon waking the next day!
 
Even if we assume that GJ does any good, that
still doesn't stop it from tasting like p!ss :p
Surely this enzyme can't be solely confined to grape
fruits? It's been getting a raw deal then =D

There's lots of this "eating this" and "drinking that"
stuff around and frankly, I doubt any of em make much
of a difference. Perhaps if you religiously follow up on
all the 5htp and vitamin C taking, drink all the right
juices and chow down on veggies and turkey (cause
it has that one trypthophan in it that potentiaties
serotonine re-uptake or performs some other magic
trick) .. I don't think it's worth it.

-
19:09:05:13.
 
Grapefruit juice is no bullshit, it is an incredibly effective inhibitor. Also tagamet (cimetidine) inhibits these enzymes but again no comment on the safety of that inhibition. Try at your own risk.
 
MazDan said:
Mate, seriously...........just take your pills...........there is NO magical thing you can take or do that will potentiate the pills abilities in any serious manner.

If there was then we would all be doing it every weekend.

Yes you may get a placebo effect or if your really really really lucky then a 1% increase............but chances are thats only gunna be a placebo to so save your energy.
Click to expand...


It's also not exclusively about potentiation, certain foods/beverages and vitamin supplements contain ingredients which can help diminish any neurotoxicity that mdma may cause.

It's not foolish to ask a question regarding something that might be good for your overall health. Your "just take your pills" mentality IMO is a dangerous mentality to have. 8(
 
purplefirefly said:
It's also not exclusively about potentiation, certain foods/beverages and vitamin supplements contain ingredients which can help diminish any neurotoxicity that mdma may cause.

It's not foolish to ask a question regarding something that might be good for your overall health. Your "just take your pills" mentality IMO is a dangerous mentality to have. 8(
Click to expand...


NO..........your wrong. The poster is on about grapefruit juice and trying to increase his high or lengthen it or whatever.............I can see where you are confused but the OP was not worried about trying to help alleviate neurotoxicity.

Had he been then my answer would obviously have been rather different.

Indeed it is not foolish to ask any question
 
MazDan said:
Mate, seriously...........just take your pills...........there is NO magical thing you can take or do that will potentiate the pills abilities in any serious manner.

If there was then we would all be doing it every weekend.

Yes you may get a placebo effect or if your really really really lucky then a 1% increase............but chances are thats only gunna be a placebo to so save your energy.
Click to expand...
lol. well said.
 
MazDan said:
NO..........your wrong. The poster is on about grapefruit juice and trying to increase his high or lengthen it or whatever.............I can see where you are confused but the OP was not worried about trying to help alleviate neurotoxicity.

Had he been then my answer would obviously have been rather different.

Indeed it is not foolish to ask any question
Click to expand...


Your answer was misleading...it was the part about "just take your pills" that threw me off.

Now that we are on the same page...we agree. We'll just leave it at that. ;)
 
I'm Actually talking about pure MDMA, Not pills, and yes I do in fact preload myself religiously, to get the most out of what MDMA experince is, I do not waste myself, in trying to act like a fool, like some of you that go on Binges of rolling for days, that for me is stupid, I believe that only certain people are allowed to really apretiate MDMA, and to understand its true Utopia, I a world that does not make sense anymore, We think We are in Control, but we are not. MDMA Makes us Understand behound our daily lifes, makes us stronger mentally, and makes us more relaxed , more easy going people, understanding the facts an importances of differences of people.


MDMA is only for a few that believe in a world of Utopia and take the message of MDMA and spread it to the world.

I believe one day this hard asses will all die and the world will be a better place with Brilliant minds, with People that all believe in Unity and Peace and Love.


Peace
Dance4Life
 
ControlFreak said:
I believe that only certain people are allowed to really apretiate MDMA, and to understand its true Utopia,


MDMA is only for a few that believe in a world of Utopia and take the message of MDMA and spread it to the world.

I believe one day this hard asses will all die and the world will be a better place with Brilliant minds, with People that all believe in Unity and Peace and Love.


Peace
Dance4Life
Click to expand...


PMSL.

Ohh dear.
 
I've tried the grapefruit thing, the 5-HTP thing, and the eat healthy thing. All didn't do anything for the roll.

The only thing that has helped me was to increase the time inbetween rolls.
 
<inhale>

Grapefruit juice is not an effective potentiator of MDMA


Now, for the 0.0001% of humanity that's actually interested in how such things work:

1. The enzyme (actually a group of functionally similar enzymes called an isozyme) that is inhibited by a chemical found in some grapefruit juice is called CYP 3A4.

2. CYP 3A4 turns slowly turns a small amount of MDMA into MDA, a more potent drug. It may also eventually convert MDA into a less inert metabolite, but I'm not aware of any research exploring that possibility.

Since the conversion process is slow, the amount converted is small (perhaps 10% over the 8-9 hour half-life of the drug), and at least the immediate conversion product is actually more potent than the original MDMA molecule, inhibiting 3A4 will at absolute best only have a trivial potentiating effect, and may even (again, trivially) reduce the strength of the experience by interfering with the production of the more potent MDA.


To top it all off, declining levels of MDMA in your body aren't the sole reason you 'come down'. That ~9 hour half-life means that if you take 2 pills, you'll still have 1.5 pills worth of MDMA in your system 4.5 hours later. But it sure doesn't feel like it, does it? There are at least two reasons for this. First, levels of serotonin (and perhaps other neurotransmitters) have probably been depleted; your brain is in a manner of speaking 'running out of gas'. Another important factor is tolerance; if there's a lot of (for instance) serotonin floating around your synapses (caused by MDMA releasing it), your brain cells will actually hide/deactivate serotonin receptors in order to try to 'tune out' the unusually strong signal.

That's why you can't stay high on MDMA indefinitely, why if you just keep taking more pills you still can't maintain that warm happy high.
 
MazDan said:
Mate, seriously...........just take your pills...........there is NO magical thing you can take or do that will potentiate the pills abilities in any serious manner.

If there was then we would all be doing it every weekend.

Yes you may get a placebo effect or if your really really really lucky then a 1% increase............but chances are thats only gunna be a placebo to so save your energy.
Click to expand...


Totally agree. I tried preloading with everything under the moon. You will not notice anything greater from your roll. Just take the E and enjoy. The only thing that will make your experience better is make sure you have good rolls, take a lot if u want, and make sure you wait atleast one month inbetween your last roll.

Post loading i'm all about. But preloading aint nothing but placebo
 
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