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Opioids Grapefruit juice and 50mg of tramadol worthless?

Hannah123 said:
You are nearly on the money with this one - great-fruit juice, Tagamet, and a host of other compounds and plant extracts inhibit the drug metabolizing drug CYP3A4 - however the more potent O-desmethyl tramadol is the product of CYP2D6 activity. I cant even remember a potent CYP2D6 inhibitor off the top of my head - a rule of thumb is that many opioid drugs are metabolized by CYP2D6. I believe the only way to achieve this end goal is in individuals with high atypical CYP2D6 activity - my girlfriend is one such person - she took a single T3 (co-codamol 30/500) for her period - vomiting, pin-prick pupils - not having a good time and displaying high dose opioid use symptoms. Codeine is a pro-drug and is metabolized by CYP2D6 to morphine.
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Quinidine is a strong CYP2D6 inhibitor and probably what people would use for this kind of thing, I think.
 
sEyEkuhDeLiK said:
To be honest I won't ever take tramadol ever again, I dosed 30 mg of racemic dl-amphetamine and 400 mg of tramadol, an hour or two later I woke up in an ambulance. Tramadol is a risky drug. Amphetamine and Tramadol decrease the seizure threshold. If one was to take Saint Johns Wort it would be with caution and proper titration until safe satisfactory results.


Stay away from Tramadol.. Immodium and Benzos/Lyrica for detox... Tramadol is a shit pain killer anyways and can often cause stomach pain. It's 1/4 opioid really.
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Dude you are so fVcking right about stomach pains. Mine are constant but i have to take this bitch pill cuz of my lower back pain, it works wonders on the pain i have. But was just looking to step up the power since i have to use every working day. hahahah You guys are really helpful for real. Atleast most of you are.
 
^if you are really looking for something to potentiate your painkilling effect, ask your doctor for a prescription for Orphenadrine citrate, it's a first generation antihistamine with pronounced CNS effects, it works as a muscle relaxer. It's also an NMDA antagonist which will reduce tolerance and increase the effects of your trams. My friend had it prescribed for this exact reason by his doctor.
 
Toz said:
50mg tramadol will do fuck all, combine it with what you want it ain't gonna make a difference anyhow since 50mg is nothing.

edit: maybe you weren't looking to get high, in that case you will get your usual pain relief, grapefruit juice or not. I find all these enzyme potentiators or whatever to be placebo.
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lol, your right im not really looking to get skyhigh but since i have to take this stupid little pill almost on a daily basis, i said why not try to make it stronger. Once i find a method whether it be grapefruit or whatever the fvck else ill take the total 150mg i usually take throughout the course of a day in one sitting , just to experiment and let you guys know the results.
 
this sounds interesting and will check it out, im looking for more of the euphoric and high feel of the tramadol. The back pain is pretty much fine with my doses. I just want that buzz and good feeling you get to be potentiated, if possible. I will start experimenting tuesday (1st work day) and will definitely repost back with results. Im hoping all the recommendations here such as quinidine and the others are easy to find stuff, like at stores etc... I also believe the route of quickly metabolizing the O-Desmethyltramadol which makes the duration of the drug shorter but stronger isnt the way i want it cuz i need pain relief for work as long as possible not shorter.
 
sEyEkuhDeLiK said:
It's a weak inhibitor RTrain and a strong inducer is Glucocorticoid.
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I see. I wonder how much of an effect it has on the beta blocker I take that is broken down by CYP2D6, cause I'd swear my pulse rate is lower than it was, but it could be the Suboxone takes less of a toll on my body than H.
 
OP

This is what you want man. Also quinidine is RX only but unscheduled in the USA.

Toz said:
^if you are really looking for something to potentiate your painkilling effect, ask your doctor for a prescription for Orphenadrine citrate, it's a first generation antihistamine with pronounced CNS effects, it works as a muscle relaxer. It's also an NMDA antagonist which will reduce tolerance and increase the effects of your trams. My friend had it prescribed for this exact reason by his doctor.
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lol tell my lower back that

I can say that I've been drinking gj the past two days and my pain relief has lasted longer. Also I should've been suffering horrid wd symptoms by now already but I haven't. :/ I say this cause Friday is usually The last day I take my tramadol medication and normally by Sunday I start feeling like shit. But ever since I started drinking the grapefruit juice (Saturday)I just haven't received any wd symptoms. I'm assuming I'll start feeling them sooner or later due to gj inhibiting the drugs effect on me.

Will test properly today before I shoot off to work. Will drink a cup of gj an hour before taking 100mg.
 
Man, all the people dissing tramadol usually have a sky high opiate tolerance or can't appreciate the subtleties of the drug. It's quite nice as long as you're not expecting a 4-hour nod.

Let us know how your experiment goes.
 
So far im noticing more symptoms that i didnt feel before such as nausea and stronger sh*tty feeling next day. The buzz is definitely more noticeable. I was really fvked up in one moment. lolz Ima see if i keep feeling these new symptoms such as nausea which i never had before. Lets see. Cuz if i feel more like crap than without gj i dont think the extra buzz is worth it, for now.
 
I love tramadol. Only in the very beginning did it give me very noticeable euphoria, but it has always maintained its ability to banish withdrawals for lengthy periods of times vs more traditional opiates(tram 8-12 hrs/hydro-Oxy3-6 hrs). It's an instant depression reliever, can give a good boost to energy, since its barely controlled very easy to get.

A great great med to have if in small to moderate pain, fighting depression, need energy, mood boost.
 
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