grapefruit juice after opiate dose?

[Cyrus]

i could not find very accurate reports on the effects (if there are any) of devouring grape fruit juice after you've dosed your DOC opiate? (in my case 10mg methadone)

i wasn't trying to potentiate it's effects, though it would be nice. i was more curious to know if it would have any negative effect? i've read in some forums that it'll "eat through your dose" but somehow that doesn't make sense to me.

 

[RedBaron]

The acidity that it adds to your stomach can destroy some of the drug.
If you wait until you feel the drug, then the GFJ won't catch up to it, but you won't get much potentiation I don't think. I've heard of people taking GFJ or cimetidine before AND during the high, but I just use it before my dose.
Anyone that's tried a CYP450 inhibitor during their opiate high care to chime in on any potentiation/longer duration?

 

[shady4091]

The actual information prevalent on this topic is shady at best. The results seem to be extremely conflicting and it's really hard to find any solid evidence on the matter. In my personal experience I've never noticed any potentation or increased duration but I've only used Red Grapefruits. I hear White Grapefruits work much better, but I also hear it doesn't matter. I hear Grapefruits will ruin a Codeine high by not allowing any to be converted to Morphine. I also hear Grapefruits will allow MORE Codeine to be converted to Morphine. I don't think I've read a single topic as controversial as this one.

Because of this it would seem like the benefits (if any) of using Grapefuits must not be that great.

 

[Cyrus]

they're just so delicious. i just hope what im eating isnt eating away my money. in my experience with oxy and hydrocodone, fresh grape fruit seems to have the most noticeable potentiating effect

 

[amapola]

Grapefruit juice is an inhibitor of CYP3A4 Awesome CYP-450 Chart!

Taking it before/with an opioid may slow the rate of metabolism of the opioid depending on how it is processed. Codeine is a prodrug which you want to be converted.

Here is a mega thread in OD on potentiation.
The Ultimate Opiate Potentiation Thread v2.0