Efficient method for virtaully withdrawal free cold-turkeying heavy use 30 day 24/7 gbl-binge:
As soon as the withdrawal symptoms hit, take 5-10 grams (roughly half tbsp of beta-alanine[5] along with good amount of water to preferably an empty stomach. Withdrawal symptoms are completely gone in 15mins. Repeat when needed.
Supportive supplements suggested: Multivitamins, zinc and additional l-theanine.
It yet seems the withdrawal is histidine and/or glutamate related.
Hence lamotrigine, memantine, and gabapentin does ameliorate the withdrawal.
References one might be interested:
[*] Efflux of a suppressive neurotransmitter, GABA, across the blood-brain
barrier. Kakee A, Takanaga H, Terasaki T, Naito M, Tsuruo T, Sugiyama
Y. J Neurochem. 2001 Oct;79(1):110-8.
[*] doi:10.1007/s00726-006-0364-4
[3] Brain Res Bull. 2002 Jan 15;57(2):231-6.
[4]
http://en.wikipedia.org/wiki/GABA_transporter
[5]
http://en.wikipedia.org/wiki/Beta-Alanine
[6]
http://en.wikipedia.org/wiki/L-carnitine
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And here is a small literature review treat with clandestine prove to all the (elder)people who have angina pectoris and are treated with verapamil[7] or isosorbide mononitrate[8]:
Quit those meds. ~1500mg beta-alanine twice a day prevents angina pectoris as efficiently than verapamil does. Same goes compared to isosorbide which is mainly used for angina pectoris but give most of people symptoms:
About beta-alanine:
"Typically studies have used supplementing strategies of multiple doses of 400 mg or 800 mg, administered at regular intervals for up to eight hours, over periods ranging from 4 to 10 weeks. After a 10 week supplementing strategy, the reported increase in intramuscular carnosine content was an average of 80.1% (range 18 to 205%)" [4]
About l-carnosine:
paraphrase: "l-carnosine is as effective as verapamil" [10]
About verapamil:
"The pain of angina is caused by a deficit in oxygen supply to the heart. Calcium channel blockers like Verapamil will dilate blood vessels, which increases the supply of blood and oxygen to the heart. This controls chest pain, but only when used regularly. It does not stop chest pain once it starts. A more powerful vasodilator such as nitroglycerin may be needed to control pain once it starts."
About isosorbide mononitrate:
"sosorbide mononitrate is a drug used principally in the treatment of angina pectoris" [7].
References:
[7]
http://en.wikipedia.org/wiki/Isosorbide_mononitrate
[8]
http://en.wikipedia.org/wiki/Verapamil
[9]
http://www.ncbi.nlm.nih.gov/pubmed/16868650
[10} Bharadwaj LA, Davies GF, Xavier IJ, Ovsenek N. L-carnosine and verapamil inhibit hypoxia-induced expression of hypoxia inducible factor (HIF-1 alpha) in H9c2 cardiomyoblasts. Pharmacol Res.2002;45(3):175.181
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Both these claims are tested in very clandestine manner in several "patients" and they work 100%. 6 months testing for the angina-pectoris use in each case.