Allylbenzene
Bluelighter
- Joined
- Jul 25, 2025
- Messages
- 982
If someone is going to try this, it would be better to use the neutral (non-acidic) form of vitamin C aka "Sodium ascorbate".
Other otc supps like creatine, agmatine and theanine (pro-GABA) will also help.
Other otc supps like creatine, agmatine and theanine (pro-GABA) will also help.
Novel Targets for Fast Antidepressant Responses: Possible Role of Endogenous Neuromodulators
Ketamine...is the prototype for novel glutamate-based antidepressants that has been shown to cause a rapid and sustained antidepressant effect. Among these molecules, agmatine and creatine stand out as those with more published evidence of similarities with ketamine, but guanosine and ascorbic acid have also provided promising results. The possibility that these neuromodulators and ketamine have common neurobiological mechanisms...is presented and discussed.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7219953/
Vitamin C, Pain and Opioid Use Disorder
This paper provides a review of the literature and a theoretical perspective on the potential roles of ascorbic acid in the treatment of pain and opioid use disorder
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As animal studies, clinical trials, and case reports have also demonstrated, vitamin C interrupts the neurochemistry of opioid tolerance and dependency and mitigates the horrific symptoms of opioid withdrawal.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7572147/
Ascorbic Acid Inhibits Development of Tolerance and Dependence to Opiates in Mice: Possible Glutamatergic or Dopaminergic Modulation
The present study was undertaken to study the effect of ascorbic acid on the development of tolerance and dependence to opiate and its mechanism of action.
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In conclusion, it is hypothesized that inhibition of development of tolerance and dependence to morphine by ascorbic acid appears to have two components, namely dopaminergic and glutamatergic.
https://www.researchgate.net/public...ible_Glutamatergic_or_Dopaminergic_Modulation
Ascorbic acid for management of oral surgery pain not responding to conventional medication: case report
Although there is no consensus as to the analgesic mechanism by which L-ascorbic acid could be acting, there are at least three potential theories accordingly with Carr et al. [7]: (a) action as a potent antioxidant; (b) role as a cofactor for the synthesis of catecholamine neurotransmitters; and (c) potential role of L-ascorbic acid in the synthesis of amidated opioid peptides.
https://www.jomos.org/articles/mbcb/full_html/2020/03/mbcb200031/mbcb200031.html
Chronic treatment with ascorbic acid inhibits the morphine withdrawal response in guinea-pigs
The effects of ascorbic acid (AA) were investigated on the morphine withdrawal response of guinea-pigs, a species which shares with man the inability to synthesize AA.
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It is concluded that chronic but not acute administration of AA inhibits opiate withdrawal.
https://www.sciencedirect.com/science/article/abs/pii/030439409290127S
Ascorbic Acid Effect on Morphine Withdrawal Symptoms in Rats
It seems that ascorbic acid administration can improve the symptoms of opiate withdrawal syndrome.
https://publish.kne-publishing.com/index.php/JCR/article/view/7154
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