Right...after recently obtaining a quantity of internet-grade GBL and converting some to the Na salt of GHB with NaOH, both chemicals were LAB (large animal bioassay) tested for comparative in vivo effects. The lab rat is extensively versed in the dynamics of many psychopharmacological compounds, but had very limited apriori experience with these particular agents.
GBL was trialed first, on different occasions, per os on an empty stomach in doses ranging from 0.75 to 3.0 ml dissolved in 50 ml grapefruit juice. The taste was described as horrible, if plastic had a burnt ass, this is what it would taste like.
At all doses, the onset was felt within 15 minutes, first evidenced by a slight queasy sensation followed by a certain dose-dependant decrease in motor coordination, and at doses over 1 ml, significant relaxation of muscle tone. This was followed by slight “euphoria” – but nothing to the extent the rat was expecting, having perused the available information.
Nausea was felt at all doses over 1.5 ml, within 30 minutes, significant nausea and vomiting at 3.0 ml and in general, the intoxication, lasting approximately 2.5 hours, felt very chemical in nature and definitely not clear-headed. The smell of the solvent remained in the mouth and came out through sweat for up to 3 hours following ingestion.
At 3.0 ml, the rat, wide awake on ingestion, felt like his mind was being forcibly taken from the awake mode and propelled into a dream-like state while still awake – but nothing like the waking dreamstates of LSD, the transition extremely rough, unwanted and unpsychedelic, with feelings of panic and some degree of psychological paralysis accompanied by vomiting, which abated within 30 minutes.
Within an hour after ingestion, the lab rat felt and was described by his girlfriend as being physically “glassy,” no empathogenic, inhibition-reducing, nor for that matter any prosexual effects were evidenced (to the dismay of the girlfriend).
The “buzz” was rather similar to a specific alcohol high – picture drinking a glass of sangria on an empty stomach on a hot sunny day – but the chemical taste and smell contributed to feeling rather more toxified. The following sleep was very deep but not overly restful and the rat had black bags under its eyes the next morning, with none of the dopamine-rebound energy or clear-headedness described in literature. At no point did the rat want any additional booster doses.
Somewhat disappointed with the above results, GHB was tried, at a later date, as per above methodology. The concentration was 1g GHB per 5ml of solution, initial trial was 10 ml. The taste, while nothing to write home about, was a significant improvement over the GBL. The onset was slower, first felt after 25 minutes, more gradual and for some reason felt much more natural.
First, significant relaxation, dissolution of underlying tension the rat was not even aware of, slight euphoria – greater than with GBL at any dose – but still felt more like alcohol than anything else, and seemingly, humour-type linguistic associations were facilitated, but perhaps only in the rat’s mind. Definitely prosexual when the rat started thinking of such matters.
At T+2, all positive effects were diminished, leaving behind a slight tiredness, so a 10 ml booster was ingested, presenting pretty much the same clinical picture, with no nausea in evidence and normal sleep with no hangover effects after 2 more hours.
Encouraged, several days later, the rat was subjected to GHB over the course of 8 hours, taking initially 15 ml, followed by 4 booster doses of 10 ml every 2 hours. The outcome of this experiment was altogether different – while the first few hours were dreamy, relaxed and euphoric as the day progressed the rat started becoming agitated – contrary to his expectations of catching a nice mid-day nap, he became more and more restless and ill at ease, a factor he attributed to the dopamine rebound.
At T+10, the rat felt like he wasn’t in his own skin, could the rat have overdosed? Rather freaked out at this point, he was experiencing some pains in the kidney region – could this be due to processing the apparently large amount of salt ingested? Had anyone else had kidney pains?
At this point, the rat was feeling rather disassociated, so inhalation of copious amounts of cannabinoid pyrolysis products and ingestion of 1.0 mg of alprazolam were prescribed, some minutes following which, a sense of “normalcy” returned and the rat was able to sleep.
So, the rat’s personal conclusions:
1.GHB significantly better than GBL on all counts
2. neither compound of much use for sleep or REM sleep induction
3. both still feel a lot like alcohol, albeit with less of a hangover
4. honestly, both proved less fun than an anticipated
5. still trying to think how these could be used for sports performance enhancement
Would be very interested to hear your comments and of your experience with these compounds. Cheers from the secret laboratory.
[This message has been edited by frqntflyr (edited 10 August 2001).]
GBL was trialed first, on different occasions, per os on an empty stomach in doses ranging from 0.75 to 3.0 ml dissolved in 50 ml grapefruit juice. The taste was described as horrible, if plastic had a burnt ass, this is what it would taste like.
At all doses, the onset was felt within 15 minutes, first evidenced by a slight queasy sensation followed by a certain dose-dependant decrease in motor coordination, and at doses over 1 ml, significant relaxation of muscle tone. This was followed by slight “euphoria” – but nothing to the extent the rat was expecting, having perused the available information.
Nausea was felt at all doses over 1.5 ml, within 30 minutes, significant nausea and vomiting at 3.0 ml and in general, the intoxication, lasting approximately 2.5 hours, felt very chemical in nature and definitely not clear-headed. The smell of the solvent remained in the mouth and came out through sweat for up to 3 hours following ingestion.
At 3.0 ml, the rat, wide awake on ingestion, felt like his mind was being forcibly taken from the awake mode and propelled into a dream-like state while still awake – but nothing like the waking dreamstates of LSD, the transition extremely rough, unwanted and unpsychedelic, with feelings of panic and some degree of psychological paralysis accompanied by vomiting, which abated within 30 minutes.
Within an hour after ingestion, the lab rat felt and was described by his girlfriend as being physically “glassy,” no empathogenic, inhibition-reducing, nor for that matter any prosexual effects were evidenced (to the dismay of the girlfriend).
The “buzz” was rather similar to a specific alcohol high – picture drinking a glass of sangria on an empty stomach on a hot sunny day – but the chemical taste and smell contributed to feeling rather more toxified. The following sleep was very deep but not overly restful and the rat had black bags under its eyes the next morning, with none of the dopamine-rebound energy or clear-headedness described in literature. At no point did the rat want any additional booster doses.
Somewhat disappointed with the above results, GHB was tried, at a later date, as per above methodology. The concentration was 1g GHB per 5ml of solution, initial trial was 10 ml. The taste, while nothing to write home about, was a significant improvement over the GBL. The onset was slower, first felt after 25 minutes, more gradual and for some reason felt much more natural.
First, significant relaxation, dissolution of underlying tension the rat was not even aware of, slight euphoria – greater than with GBL at any dose – but still felt more like alcohol than anything else, and seemingly, humour-type linguistic associations were facilitated, but perhaps only in the rat’s mind. Definitely prosexual when the rat started thinking of such matters.
At T+2, all positive effects were diminished, leaving behind a slight tiredness, so a 10 ml booster was ingested, presenting pretty much the same clinical picture, with no nausea in evidence and normal sleep with no hangover effects after 2 more hours.
Encouraged, several days later, the rat was subjected to GHB over the course of 8 hours, taking initially 15 ml, followed by 4 booster doses of 10 ml every 2 hours. The outcome of this experiment was altogether different – while the first few hours were dreamy, relaxed and euphoric as the day progressed the rat started becoming agitated – contrary to his expectations of catching a nice mid-day nap, he became more and more restless and ill at ease, a factor he attributed to the dopamine rebound.
At T+10, the rat felt like he wasn’t in his own skin, could the rat have overdosed? Rather freaked out at this point, he was experiencing some pains in the kidney region – could this be due to processing the apparently large amount of salt ingested? Had anyone else had kidney pains?
At this point, the rat was feeling rather disassociated, so inhalation of copious amounts of cannabinoid pyrolysis products and ingestion of 1.0 mg of alprazolam were prescribed, some minutes following which, a sense of “normalcy” returned and the rat was able to sleep.
So, the rat’s personal conclusions:
1.GHB significantly better than GBL on all counts
2. neither compound of much use for sleep or REM sleep induction
3. both still feel a lot like alcohol, albeit with less of a hangover
4. honestly, both proved less fun than an anticipated
5. still trying to think how these could be used for sports performance enhancement
Would be very interested to hear your comments and of your experience with these compounds. Cheers from the secret laboratory.
[This message has been edited by frqntflyr (edited 10 August 2001).]
