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Bupe For those who go Back and Forth Between Bupe and Other Opioids

R

romealone

Bluelighter
Joined
Jan 28, 2010
Messages
112
I wanted to ask something for those who have experience bouncing back and forth between bupe and full agonists, or those who use full agonists on top of bupe.

I have been taking bupe maintenance for two years. I am down to a low dose of only .5mg per day. On this low dose I find that I can take full agonists on top of the bupe without the bupe blocking the effects much. So for the last few weeks I have been taking my daily .5mg of bupe a day, plus I am taking dilaudid on top of that (4mg, twice per day).
Like I said, I've been doing this a few weeks but have been taking my daily .5 of bupe as well. I am just wondering what I will experience when I stop taking the dilaudid and go back t just bupe. Will i likely experience any withdrawal since I will be going from full agonist plus bupe to just bupe, or will the daily bupe I take make it unlikely that i will experience withdrawal.

I know many ppl here on bupe maintenance go thru periods of using full agonists during their treatment, so I was hoping those with experience with this could let me know what to expect. Thanks
 
i dont know about dilaudid but im kinda wonderin the same shit.. cept i just did a cwe and i was wonderin if id be alright to potentiate it with a very small does of bupe.. becuae ive noticed that if you take somethin weak and a small dose of bupe they actually synergize well but ive only done it like 2 times so i really dont know that much about it.. and it was always been a low dose like 10-20 mgs of hydrocodone and then + .5-1.0 mgs of bupe
 
Why do you take both? You definitely don't need to be taking bupe along with diluadid. Its just a bad combo if you ask me. Bupe doesn't mix well with other opiates.

To answer your question. You may feel slightly uncomfortable for a day, like depression/lethargic. but thats it. No major WD or anything.
 
Ive never heard of someone continually dosing bupe and full agonists, as it's not something that generally works well for people. But since you don't seem to be expereiencing precipitated withdrawal, I would imagine that if you stopped taking the dilaudid, you would probably feel the need to take more buprenorphine, as you are essentially raising your tolerance. Hydromorphone and buprenorphine are both potent opioids, so you might feel a little uncomfortable dropping the dilaudid. If you added an extra .5mg of bupe in the evening in place of it, that would probably take care of it.
 
it is definitely a matter of opinion on whether or not bupe and other opiates go well together. my boyfriend actually quite enjoys the combination. he will take a small dose of bupe in the morning, around .25-.5mg, then dose a full agonist; typically oxycodone or hydromorphone (dilaudid) a couple of hours later (or in some cases very soon after his bupe). he has always told me that he feels he gets a stronger high, though a bit different. he thoroughly enjoys the synergy.
i experienced this positive effect only once from the combo and don't like taking bupe the same day as a full agonist as i personally feel it is just a waste of my bupe supply for when i am sick.

to answer your question about removing the full agonist from your routine: you shouldn't experience any major withdrawal symptoms. as epiks and znegative suggested, any discomfort will be very minor and probably more psychological than physical, and is nothing that a small increase in your daily bupe dose won't cure. may i ask why you have been taking the dilaudid recently? was it prescribed to you, or just for a short "recess" during your bupe treatment?

paper planes: when mixing the bupe and hydro, which were you taking first? do these amounts you listed above reflect your tolerance? has this been your tolerance or has it actually dropped from something higher? just curious.
 
Bupe is subutex, right?
I'm from the UK and bupe isn't a word I hear here.

I sometimes snort subutex (1mg) and if I do dihydrocodeine too soon afterwards it doesn't work as well, cos the subbys are a blocker.
I see from this thread that people have taken agonists and antagonists together, but I'm iffy about using subutex too soon after opiates, cos of the precipitated withdrawals I hear about. Having said that, the first time I had a line of subutex (1mg), I had taken either dihydrocodeine or codeine (not a low dose) earlier in that day.

I've never heard of dilaudid in the UK, or how strong an opiate it is, but maybe the dilaudid amount over-rode the small subutex (bupe) amount.

I've known people in the UK who are scripted subutex due to their heroin habit, but they use H on top sometimes, never figured out how that quite worked, unless they don't take the subutex on the days they use.
 
With short acting opioids it is pretty easy to switch from the full agonist of your choice to bupe. I'd be able to switch from oxycodone to bupe when I was low on cash or my dealer was out of full agonists after 24 hours since my last dose. With methadone on the other hand it becomes a bit trickier. You are going to have to wait a lot longer, and this period of time can defer drastically as, the longer one is on methadone, the longer the half-life of the methadone can potentially be (even 60 hours +). People have had PWD +72 hours after their last methadone dose.

I recently switch from methadone to bupe (20 something days ago) and waited 48 hours till I dosed the bupe. This could have been pushing it, but I wasn't on the methadone for that long of a period of time. The last 24 hours before dosing the bupe were pretty damn uncomfortable, but mostly because of the anxiety and RLS symptoms. I already have severe RLS, so stopping opioids makes it 100x worse.

I haven't personally dosed really anything other than methadone or tramadol on top of low dose bupe, 1 mg or less, but it was definitely stronger than either methadone or tramadol dose alone, as long as I wasn't on the bupe for an extend period of time building a opioid tolerance.
 
3d music said:
Bupe is subutex, right?
I'm from the UK and bupe isn't a word I hear here.
Click to expand...

Bupe is short for buprenorphine which is the name of the opioid in the brand name drug Subutex and Suboxone (the later of which also contains the antagonist naloxone).

OP said:
Will i likely experience any withdrawal since I will be going from full agonist plus bupe to just bupe, or will the daily bupe I take make it unlikely that i will experience withdrawal.
Click to expand...
As others have said you may experience mild withdrawal in that you are reducing your overall dose of opioids a fair amount by dropping the hydromorphone.
 
allegator said:
Bupe is short for buprenorphine which is the name of the opioid in the brand name drug Subutex and Suboxone (the later of which also contains the antagonist naloxone).


As others have said you may experience mild withdrawal in that you are reducing your overall dose of opioids a fair amount by dropping the hydromorphone.
Click to expand...

Thanks for clarifying bupe.
 
ive always takin the full antagonists first and then a little bupe later and they always synergize well and yes its a little different high but its not bad.. i didn feel much off of the CWE of 50 mgs of hydrocodone but about 2 hrs later i did maybe 1mg of bupe and i felt good...
 
3dmusic said:
Bupe is subutex, right?
I'm from the UK and bupe isn't a word I hear here.

I sometimes snort subutex (1mg) and if I do dihydrocodeine too soon afterwards it doesn't work as well, cos the subbys are a blocker.
I see from this thread that people have taken agonists and antagonists together, but I'm iffy about using subutex too soon after opiates, cos of the precipitated withdrawals I hear about. Having said that, the first time I had a line of subutex (1mg), I had taken either dihydrocodeine or codeine (not a low dose) earlier in that day.

I've never heard of dilaudid in the UK, or how strong an opiate it is, but maybe the dilaudid amount over-rode the small subutex (bupe) amount.

I've known people in the UK who are scripted subutex due to their heroin habit, but they use H on top sometimes, never figured out how that quite worked, unless they don't take the subutex on the days they use.
Click to expand...

What is great about buprenorphine, it's a long lasting partial agonist & found to work well for some types of chronic pain...My Pain Dr. is experimenting w/ it in terms of combining a small amount of it with full IR meds' it prevents the 4-5 hour (pain) rebound effect. Meaning, it actually prolongs the analgesic effects of opioids for 8-10 hours w/o the desire to re-medicate to achieve the (high) along w/ the pain killing properties, It actually levels out the euphoric aspect, while lengthening the analgesic properties
taking your mind off of the high chasing merry-go-round.
 
^ That's interesting. I read something like this on another website. Are you using low dosage Butrans patches? I ask because I can only imagine buprenorphine working alongside a full agonist, if the buprenorphine dosages are rather low, but constant.
 
2 mg's of Subutex (tab form) along w/ 30 mg's of oxycodone hcl, It does away w/ the rebound. I have not felt the need to up the dosage. I get a good 8 - 9 hours of pain relief. I was sceptical when my pain Dr. suggested it, but after 6-7 other extended relief meds', combinations of new nerve medications w/ beta blockers, this combo' beats everything I am thinking about trying 1 mg. of Bupe' w/ 15 mg's of oxycodone to see if it gives me close to the same amount of relief. The patches do sound like a good idea, but this new generic Midlothian Buprenorphine is very cheap compared to the VERY expensive patches.
I wish there were more pain specialists like my Dr. He is even compassionate about my wallet (writes me 4 mth. advance scripts') I see him 3 times a year now. We even talked about dividing the doses (.50, 2-4 times a day) with 5 mg's oxycode'...
 
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