First ever large-scale study of ketamine users published

godskitchen

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The first ever large-scale, longitudinal study of ketamine users has been published online today in the journal Addiction. With Ketamine (K, Special K) use increasing faster than any other drug in the UK (British Crime Survey, 2008) this research showing the consequences of repeated ketamine use provides valuable information for users and addiction professionals alike.

For the study, researchers from University College London followed 150 people over a year to see if changes in their ketamine use could predict changes in their psychological well-being, memory and concentration. Of these 150 people, 30 were taking large quantities of the drug nearly every day, 30 were taking it 'recreationally' (once or twice a month), 30 were former users, 30 used illicit drugs apart from ketamine and 30 did not use any illicit drugs.

The authors found that the heavy ketamine users were impaired on several measures, including verbal memory. Short term memory and visual memory in this group decreased over the year as ketamine use increased. These individuals also performed more poorly overall on verbal memory, displaying symptoms such as forgetfulness and experiencing difficulty recalling conversations and people's names.

The amount of increase in ketamine use over the course of one year was also a source of concern. Hair analysis showed that ketamine levels among recreational users doubled at follow-up compared to initial testing, a pattern seen with other addictive drugs. Ketamine levels in the frequent using group did not change across the year, but this group was already using up to ten grams per day at initial testing.

Interestingly, the recreational ketamine users and ex ketamine users did not differ from non-drug-taking controls on memory, attention and measures of psychological well-being, suggesting that occasional ketamine use does not lead to prolonged harms to cognitive function and that any damage may be reversed when people quit using the drug. However, all groups of ketamine users showed evidence of unusual beliefs or mild 'delusions', with these being greatest in the frequent users and least in ex-users (i.e. it appeared dependent on the amount of the drug used). It is not clear to what extent this is a pre-existing difference in ketamine users, something that develops from using the drug or a mixture of both.

Says lead author Dr. Celia Morgan: "These findings have implications for the growing number of ketamine users in the UK as well as addiction professionals who may encounter increasing numbers of ketamine dependent users. These findings suggest these frequent ketamine users will be impaired, albeit transiently, in a variety of psychological domains."


Public release date: 16-Nov-2009

http://www.eurekalert.org/pub_releas...-fel111309.php
 
Largest Study On Ketamine Users Finds Long Term Effects Of Drug Can Be Reversed

London, England (AHN) - Researchers conducted the first ever large-scale, longitudinal study of ketamine users and reached some interesting findings about long term use of the drug that has a variety of medical uses but it is increasingly used as an illicit drug because of its hallucinatory effect. The findings suggest occasional ketamine use does not lead to prolonged harms to cognitive function and damage can be reversed when people stop using the drug.

According to law enforcement officials in the United Kingdom Ketamine (K, Special K) use is increasing faster than any other drug in the region. Curiosity about the drug's effects and its rise in popularity prompted researchers from University College London followed 150 people over a year to see if changes in their ketamine use could predict changes in their psychological well-being, memory and concentration.

Of the study participants 30 were identified as taking large quantities of the drug nearly every day, 30 were taking it 'recreationally' (once or twice a month), 30 were former users, 30 used illicit drugs apart from ketamine and 30 did not use any illicit drugs whatsoever.

Researchers ascertained that the heavy ketamine users were impaired on several measures, including verbal memory. Short term memory and visual memory in this group decreased over the year as ketamine use increased. These individuals also performed more poorly overall on verbal memory, displaying symptoms such as forgetfulness and experiencing difficulty recalling conversations and people's names.

The amount of increase in ketamine use over the course of one year was also a source of concern. An analysis of participants hair showed that the group identified as recreational users of the drug showed signs of doubling up on the substance. Meaning that after their initial testing and baseline data results, they exhibited typical addictive behavior towards the drug as seen with other addictive drugs. Ketamine levels in the frequent using group did not change across the year, but this group was already using up to ten grams per day at initial testing.

However, a finding not typically expected was the fact that the recreational ketamine users and ex ketamine users did not differ from non-drug-taking controls on memory, attention and measures of psychological well-being, suggesting that occasional ketamine use does not lead to prolonged harms to cognitive function and that any damage may be reversed when people quit using the drug.

All groups of ketamine users in the study showed evidence of the hallucinatory effects the drug is known to elicit. It remains unclear to what extent this is a pre-existing difference in ketamine users, something that develops from using the drug or a mixture of both.

Ketamine produces effects similar to PCP and DXM. Unlike the other well known dissociatives PCP and DXM, ketamine is very short acting, its hallucinatory effects lasting sixty minutes when insufflated or injected and up to two hours when ingested, the total experience lasting no more than a couple of hours.

Ketamine is originally created to be used in human and veterinary medicine. With humans, the effects of the drug can include analgesia, anesthesia, hallucinations, elevated blood pressure, and bronchodilation. However, in humans it is primarily used for the induction and maintenance of general anesthesia, usually in combination with some sedative drug.


Ayinde O. Chase - AHN Editor

http://www.allheadlinenews.com/articles/7017007633
 
Says quite a fucking bit imo

/waits for the fanboys to come and defend it against the indefensible
 
says nothing

It says quite a bit, but it definitely depends on how you interpret it.

The first article takes a while to get to the results, which makes it seem neutral, but then the results begin with "The authors found that the heavy ketamine users were impaired on several measures, including verbal memory." before they go into detail about the impairments.

The second article starts off - in the title - with a positive perspective: "Long Term Effects Of Drug Can Be Reversed"

The study they are talking about is the same, but what does it really say?

1) That heavy use of K is linked to certain types of cognitive impairment.
2) That light use of K is not linked to these types of impairment, or any others that they tested for.
3) That ex-(heavy?)- users do not show any types of impairment either, which suggests that the impairment is temporary.

I wonder if alcohol users would show similar types and strengths of impairment with correspondingly heavy doses.
Anyone out there know of any such studies?
 
this group was already using up to ten grams per day at initial testing
so basically if your doing more than an 8ball a day your going to have temporary problems

who would of thunk it
 
They would definitely be in the heavy-user category, people using a few times a month don't seem very likely to be getting through 3-5g a session. People do it though, heh...

Interesting study, I would imagine the major memory and health issues have been seen with people really kaining ket and doing it daily, in grams, but then it does certainly suggest even occasional use can cause issues too.

Personally I think the "supernatural" bit is condescending fucking bullshit (although we all want to talk to dolphins on ket amirite?). "Do you believe that the jewish zombie son of god was reborn and that when you eat bread and wine you are nom'ing upon his zombie flesh and blood...... seriously??" Dunno if they'd take such stuff into account....

The samples aren't big enough I don't think, also, 30 people per category, it still says a lot, but it might not be so clear cut. 30 users, all from same city? possibly similar background? I think a guy called Justin was looking for users on the internet for this a few years back; that could affect results if you're getting participants in that way...
 
I think a guy called Justin was looking for users on the internet for this a few years back; that could affect results if you're getting participants in that way...

Yes there was someone asking for users in the UK (based in London but I don't think the subjects were limited to the city) a while back. Not sure if they were a Justin or a Jane or what though.

Anyhoo, an interesting study and says a bit about something which hasn't had enough study (as with a lot of drugs really). Hopefully more news will come of this :)
 
I would like to know which isomer was used. Why none of these heavy users didn't report and urinary symptoms or the horrible k pains.

30 people in each category I don't think was enough, especially for the heavy users.

I've done 2-4g a day for a year. Surprised they also didn't say the effects the salt has on your nose. I have an extremely big septal perforation from it. The size from 6 months or so went from a pinhole, to bigger than a cigarrette filter:\:( I never took care of my nose. I was oblivious to the fact that you really can burn a hole through your nose. It's not just the septum either. The inside of my nose, where it goes to the lower sinuses is just one big fucking hole. Where they drain, I have holes in the back of my throat. I'm pretty sure the inside of my face is hollow........:|

As for the k pains, I believe they are temporary. Stomach ulcers maybe?

The urinary problems are very real. There has been other studies on it, I don't know why they didn't throw in any physical harm studies. I myself have actually pissed out k and blood. I wish there was more information on how badly it really harms you with abuse.

I have also experienced forgetfullness, can't remember people's names worth shit. You wouldn't believe how many people come up to me at a show and say hey.....what's going on. And I reply with....do I know you? Everytime.

I have cut back drastically on my usage however. If I kept going as I was, my nose would surely cave in and further hollow out my head. When I do use, IM is the way to go.

Sometimes I hope I could be a study
 
As for the k pains, I believe they are temporary. Stomach ulcers maybe?

In all the years I have used ketamine, I have never suffered from these 'K pains'. Neither have any of my friends that have used it.

The urinary problems are very real. There has been other studies on it, I don't know why they didn't throw in any physical harm studies. I myself have actually pissed out k and blood. I wish there was more information on how badly it really harms you with abuse.

Someone on here mentioned in a previous thread that it wasn't that ketamine caused the urinary problems directly, it was that ketmaine made some users more susceptible to urinary tract infections.

And as I have said before, I reckon it's a combination of the additives of a certain brand of ketamine, dehydration in the user and (metabolites of) the drug itself. I'm no pharmacokineticist though! :)
 
If I remember correctly, FastandBulbous has said that ketamine has a metabolite (norketamine) that causes thickening and scarring of the bladder (and damage to the kidneys). With occasional use this isn't that big of a deal (it has time to heal), but with constant use your bladder becomes smaller and smaller as scar tissue grows. There was a thread in "The Dark Side" where a kid had to get his bladder removed. So, yeah, don't become addicted to K.
 
^ I remember that thread, pretty scary stuff! I think there are too many cases of the bladder damage and K pains for it to be a coincidence but it could jbe K making people more susceptible to other conditions rather than causing them itself.
 
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