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  • BDD Moderators: Keif’ Richards

First day ever trying anti-depressants...placebo effect?

shpongle1987

shpongle1987

Bluelighter
Joined
Feb 22, 2011
Messages
520
Location
NY
A little bit of background...For the past 4 years of my life I've become gradually more depressed. For the first 3 of the 4 years I was taking practically daily high doses of DXM...which i think mite play a role in this.....but over the past year I haven't been using psychedelics nearly as much as i was. Ive tried just stopping taking anything all together in the hopes that it mite get me out of the funk but being sober didn't help. So I pretty much caved and tried a antidepressant recommended by my doc..zoloft...told me to take 25mg once a day the first week then 50mg the next. I took 25mg today around 1245pm and about 20 mins later I started feeling strange..but I think it was just me trying to feel out the foreign drug and the fact that I didn't know what to expect. So at about 2oclock I smoked one hit of some grand daddy purp and I literally could not stop smiling. I was so fucking happy is was crazy....and i knew it wasnt just the weed because ive been smoking the grand daddy for the past week and its never gotten me that happy..no weed has. So im wondering if it placebo effect..due to the fact that ive heard anti depressants usually take about 2 weeks to kick in. Any one have anything like this happen to them?
 
yes, SSRI's are the shittiest drug's out there. they work for some people, but for most, they don't do shit...
 
^^ yeah for years I was sooooo against taking any ssri's, but I figured I would just give it a try after I tried everything else but to no avail...therapy ect.
 
yeah SSRIs take a good while to start working. Ive tried 3 different ones, and refuse to try any others. They make feel horrible, like im on a low dose of LSD, clenching and twitching muscles, paranoia, worse insomnia than normal, yet dragging ass tired all day etc. To me, SSRI's are disgusting garbage .
 
Well most of those side effects are suppose to go away by 2 weeks. I'm in the same position bro, never liked the idea of anti d's. This is my 2nd day of taking zoloft, i did 25 mg the first day and 50 today. My doc is saying to take more but i'm taking it slow, i feel like i'm jittery and speedy on it. This is normal as i have been reading, most people don't give them long enough . I highly doubt your feeling it , like you i was smoking on it to and i still didn't feel any happier. It should take a good 1 week or 2 at least, in that time we should be feeling side effects and crappier than our normal self.

Keep updating dude, i want to know when you start feeling it with out weed. Atm i really don't like how it is making me feel, my mood is the same but it makes me jittery and such with other side effects.
 
^^honestly man since ive taken the 25mg I have been feeling pretty damn good all day, a bit speedy if anything.Tomorrow I was thinking about upping the dose to 50mgs like you did but I think I mite try another day on 25 then work my way up to 50 just so my body gets used to it...but honestly i have yet to have any bad side effects. I live in ny so its like 145 so im about to pass out...kinda have a light headache going as i write this but no way to tell if thats due to the zoloft. I will keep updating tho and let you know how its going man, im interested to see how your experience with it turns out as well.
 
^ feeling a bit "speedy" is common - often it can be quite unpleasant and can make you feel jittery, nauseated, a little anxious, unable to sleep etc - but these side effects generally do subside within a week or two. When I started taking venlafaxine I felt like I was coming up off a pill - I had jaw clenching, pupil dilation and a general comeup-ey feeling for the first few days! It lasted around a week to 10 days for me to go away entirely. Sometimes antidepressants can actually send people manic, so it is important to report any mood changes to your doctor, but this is very unusual unless you have bipolar disorder. The antidepressant effects are supposed to take 2-4 weeks to kick in but I remember reading somewhere that some people do find that they get a result much faster. This could be placebo; I can't remember the paper and I can't find it now, sorry!

I would increase your dose at the rate your doctor suggests, but I am really glad you aren't getting any nasty side effects. Yes SSRIs don't work for a lot of people and some people find them to be pretty unpleasant drugs, but they also do work well and are well tolerated by a substantial number of people too.
 
Day 3 here, 50mg again i haven't given it long enough to kick in. But something feels different with me, i have been smoking less pot but my head feels a little more clear or sharper. I think that's a mix of the zoloft and cutting down on bud but i think i am slightly feeling it because something feels different with me. Like you i have been pretty down for 4 years as well, but i can attribute that mostly to drug use. What is your drug use like besides the DXM and psyches, were you smoking pot daily or using MDMA?
 
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Ive been smoking weed pretty much daily for the past 6 years or so. The only other drugs I used were dxm,lsd,ketamine and mushrooms.....ive only tried molly 3 times in my life so im pretty sure its not serotonin depletion due to that. This morning I actually randomly blew a few mg's of opana which I never really do...and I just took my 25 mg's like 5 mins ago so im curious to see the reaction. Ive heard mixing opiates and ssri's is all good unless its tramodol so I think I should be good.
 
I tried 2 SSRI's which did no good, Citalopram, sertraline (zoloft) which was even worse so my doctor eventually moved me to to Venlafaxine (an SSNRI) which i was on for one month at 75mgper day and then moved up to 15 mg per day for the next month, the first 7 - 10 days i felt a nauseus and lost my appetite but then that went and slowly over the course of the remaining 2-3weeks i felt ever so slightly better which to my doctors delight she pescribed a 3 month repeat prescription.

I must stress i felt ever so slightly better, nothing hardly life changing, but many health professionals (IME) assume any slight positive step is a massive positive step.

I still have a raging Benzo addiction/tolerance though :( i just consumed (<a large dose of> Temazepam<lets keep our high tolerance doses to ourselves>) and thats not a boast or anything im proud of its just a sad fact in my life.

Good luck to you all ;)
 
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Citalopram just gave me shitty side effects, and so i never gave them a chance i had to come off after 2 weeks, after one night i got body disassociation with TONS of anxiety.... felt like i was just floating in the air and that id never get back into my mind. Lasted alll but 5 minutes (my bro said i was unresponsive for that long) But it felt like an eternity


I shouldnt have i know but ive been using ket every week since instead. However. . . . . . ive been doing this for months and im on anti biotics so i assume its not safe to mix them? i usually dose the ket every weekend, just one decent dose Near hole / in k hole dose. Lovely afterglow, but i cant do that atm, i am feeling a bit mood swingy without it tbh! . Arghh!
 
Ive only tried one anti-depressant, cipralex (escitalopram). I have to say, its actually quite amazing in stopping me being depressed. But after 1 day usage of an anti-depressant its definetly placebo effect. They take like 2-3 weeks to kick in. It took 2 weeks for me to first notice any effects off me and that was actually me taking a significant turn for the worse. I became suicidal (as opposed to before where I was borderline). Luckily I thought to book an appointment with my doctor and I spoke to him and he said to stick through it because sometmies it gets worse before it gets better. Also I had a really good talk with a close friend of mine on the same day. But Im glad I did stick to it because now I feel so much stronger and happier.
 
darksidedsam said:
Citalopram just gave me shitty side effects, and so i never gave them a chance i had to come off after 2 weeks, after one night i got body disassociation with TONS of anxiety.... felt like i was just floating in the air and that id never get back into my mind. Lasted alll but 5 minutes (my bro said i was unresponsive for that long) But it felt like an eternity


I shouldnt have i know but ive been using ket every week since instead. However. . . . . . ive been doing this for months and im on anti biotics so i assume its not safe to mix them? i usually dose the ket every weekend, just one decent dose Near hole / in k hole dose. Lovely afterglow, but i cant do that atm, i am feeling a bit mood swingy without it tbh! . Arghh!
Click to expand...

Crazy about the out of body-esque trance-like state you got from them, very weird. Unresponsive too... that's no good (think about the implications of that while driving, for instance..)

And Ket always gave me a wonderfully anti-depressant afterglow. I too suffer from anxiety and depression which led me to drugs (and social inadequacy). Which anti-bios? Every one is different, and would react differently. Also, everyone's body is different.

I was happily tripping/rolling along while taking doxycycline (general anti-bio) for yet another case/spike in my Lyme levels and only noticed the similar side effects from the anti-bio. Being outside was absolutely miserable, yet I LOVE being outside (when it's warm - cold weather is #1 to blame for my <3 for opiates).
 
Day 5 i think on zoloft, side effects pretty much all gone since day 3. Which is good because day 1 and 2 was horrible, i was going to throw them out but i read side effects go away which they did. Mood change, um i don't really see any. It could be very subtle and i'm not noticing but i guess i have less negative thoughts? Was on vicodins and smoking a lot last night , stupidly did a little blow and it almost sent me into a panic attack. I think its cause zoloft also inhibits dopamine, dunno i just felt super edgy and stuff. Anyways the zoloft is not making me feel any worse, so i have no choice but to keep at it hopefully it'll make me happier or some shit by week 2 or so.
 
i have taken +15different ssri and what not, none of witch touched my depression and anxiety the tiniest, i hate the side effects some made me feel' and the just dulled persection not helping just masking the things a bit... i cant for the life of me wonder out why they give suicidel mental patients ssri and send them home,...(ohh well thats for a nother time)...

then one day after about 2 years of trying diffent drugs my doc said we could try oxazepam for sleep and for anxiety when needed and after that all changed, not becourse of the medecine(i have ubesed them and is a addict,) but becourse the medecine slowly led me get back my old social life, i was tottally isolated at that point and its first now about 2 years more later its gotten back to somewhat normal life...

i dont use them every day, and i can go a weeks without, but when i have it i can allways take one relax and escape a little from all the chaos i know its wrong, but the only think that helped just a bit, i have abused plenty of much stronger benzo's and i actully think oxazepam is perfect for anxiety/depression/insomania/just relax a bit, just a small dose,
and i can be happy and relax without all the darkness, or sleep or just get me in mood for the days tasks it really works

it should be pointed out if you do use benzo's only use em when needed! not 3x a pill like some doctor tells you and they can really be help/usefull and you dont get addicted like if you take em every day.

JUST PLAESE DONT OVERDO EM! - then they dont help you! but will make it all worse! - Use only when needed!

well, i know i sound like some advatisement but just keep looking for a drug thats work for you, may it be ssri/snri/gaba or just some talk and activities in your life, you will only find it if you keep looking, and believe me when i say you will find it!

here are some things that works for me (depression/anxiety):
sunlight - (and lots of it, a b-vetamin lamp can even help, but is nowhere neer real sun)
activities(active and social prefered, some sort of body training need to be hard.)
good food, nutricients - (important to get your vitamin and nutrucient levels back.)
sleep cycle - (important, can be reduced or increased by depression, but keep rutine times.)
good rutines - (get up, eat, do some rutines, go to sleep the same times.)
cleaning - (yeah maby its not funny but if you do it it helps you allaround, social, mood,)

medicine - (Only if needed, medicine are only a last resort!.)
anti-depressive (SSRI/SNRI, do em if you think they work for you!)
opiates (it will only make it worse in the long run!)
benzo's (i use between 7.5-30mg oxazepam for anxiety or sleep. - only when needed! - if you overdo em they will make it worse!)

please find what works for you and only use medicine if you think thats what you need to do, i will advice you to try some of the other methods i wrote, i can my self tell you they work! with no side effect besides you getting better and better, where as medicine only masks the problems!'

sorry for my wasten sunday night rent ;)
 
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day 3..upped the dosage to 50mgs. Felt shitty in the beginning of the day but I think its due to the fact I blew 20mg of opana yesterday. Around 6pm i grabbed a 6 gram nug of some nice sour desil, took three big hits and was feeling amazing. Since those three hits i've worked out...working out pretty much consisting of doing some stuff on my weight bench, sit ups and curls....which is weird because I rarely work out, but have been for the past 4 days. After I worked out I felt amazing. The main thing I realize tho is that I don't really feel good throughout the day until I take my first hit of weed, and im deff not getting the extreme happiness any more from smoking...just regular bud highs. I plan on trying to stay away from anything narcotic and just stick to weed...pretty much cuz i just hate coming down off opiates and i feel like the comedown i had from the opana was more drastic then usual due to the zoloft.
 
please dont mix your ssri's before studying more about interactions and let em start to work(2-3weeks?)... just at advice...

zoloft made me have some nasty jitters(panic attack thingy) and tingling the first few days when on 50mg... so be aware when you take such stuff, read the side effect and learn what to do if you start to feel anyway thats needs attention :)

good luck with the treadment, zoloft did work aventully a bit, no miracle cure tho
 
speaking of interactions, I am an avid lover of all psychedelics and this is my first time ever using an ssri....what drugs should i stay away from? I know I cant use dxm any more but is it ok to use ketamine (I mostly use dissociatives)?
 
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