when i had a lortab habit where it only took (8) tablets to get high 7.5mg, once i put a 50mcg patch on my arm, i got so sedated, extremely nauseous, bed ridden, i had to take the patch off early in the morning, i couldnt handle it, i was so disgusted with it i flushed the patch, and it didn't even cause euphoria like ur typical opiate dose...even to this day. i can slap 100mcg patch on my arm now and be fine. i personally feel the effects within 2 hours. the other downside is EXTREME ITCHING keeping you up all night. i usually just take the gel and use it sublingually, i tried IVing it, and had no effect oddly. the Transdermal patches (the ones without gel SUCK, my reasoning: They dont even stick on to your body good, it starts coming off my body by just moving around..the Gel ones (duragsic) are very stick. people please save ur time dont try smoking it, its dumb, lasts 3 mins and its a tiny buzz, and u gotta keep taking hit after hit, just slap the bad voz onur body, or use it sublingually (gel, under tongue) the non gel patches cut in pieces and place all in ur gums, other then that its a waste. such a fast acting narcotic