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  • BDD Moderators: Keif’ Richards

Fentanyl and tolerance questions

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GrantchesterMeadow

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Nov 3, 2010
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Hi guys

I'm planning to consume my 25mcg/h fentanyl MATRIX patch buccaly, which contains 5,78 mg.

So I've read the megathread and lots of other threads about dosing, but everywhere you refer to oxy tolerance. The problem is, i have NO experience with either oxy or hydro or any codeine substances.
Yet I have quite high tolerance to tramadol (5-600mg) kratom, alprazolam(6-7 mg) and alcohol, sometimes combinating all of them. And lets not forget my natural tolerance to almost everything due to my high body weight

SO my first question would be, if any of these matter at all while speaking about how much fentanyl to take.

RIght now im thinking about 1/16 of the patch which would mean 361,25mcg fentanyl, but since its my only chance with this drug, maybe double the dose to 722,5mcg.

That'd be all, I hope my english skills dont make it ununderstandable
 
i think you should cut the patch into quarters, allowing you to absorb 6.25mcg/h. leave the strip in your mouth for ten minutes at a time, waiting up to 30mins for the dose to peak and titrate from there. you can reapply the piece in your mouth if you're not where you're at.

bucally, you're absorbing the drug a lot quicker with a reasonably high bio-availability so you definitely want to take it slow if you've got little experience and tolerance to opioids in general. fentanyl definitely isn't something light to step right in to.
 
Okay, so you're saying 1445mcg (1/4 patch) can be relatively safely used with that tolearnce? I got responses elsewhere, that high benzo/tramadol/alcohol tolearnce doesnt mean anything when its about fent.
 
The smart thing to do is DONT DO IT AT ALL the drugs u talk about are junk and then u wont to jump right in with fent.you are out of your mind!!!!!
 
I appreciate your effort to talk me out of this, call me irresponsible, but im not gonna miss this oppurtunity.
And now im not trying to sound some badass "bitchin' rockstar from Mars", I'd just rly like to read some useful advices to minimalize the risk.

Thanks for the replies so far by the way:)
 
there's going to be minimal cross tolerance with tramadol as it has minimal affinity to mu receptor (o-desmethyltramadol, the active metabolite). alcohol and benzo's are gaba drugs so no cross tolerance there. avoid taking these with the fent as it adds CNS depression and increases chances of overdose.

your best bet is to start minimal as possible and titrate from there. if you feel cutting the patch into 1/8ths rather than 1/4 then that is going to be a safer option.

many people, including myself, don't find fentanyl very recreational. there's little to no euphoria but plenty of sedation.
 
1/16th is probably a safer point to begin with. practicing such safety is reassuring to hear.

GrantchesterMeadow said:
One more thing: Can my last night xanax and tramadol (12 hours ago) cause some problems?
Click to expand...


the xanax should have cleared out of your system as it has a very short half life. however tramadol has a half life of around 12 hours. it shouldn't accumulate to a lethal dose with the fent if you took a reasonably low dose as in no more than <400mg.
 
Okay, if anyone interested, i finished two 1/8 pieces in an hour. I'm feeling the typical "something is gonna happen" placebo effect.

IF I understood correctly, the sticky side must be connecting with your CHEEK, not your GUM, right? Its rly hard to place it correctly, if i put it upside down, would it kill the whole effect?

I heard, you shouldnt mix it with any CNS depressants, but even a bottle a beer is forbidden?
 
Buccal is the least efficacious ROA for fentanyl; however, I would I say if you don't want to use at least an alcohol extraction or wear it -- that your BUCCAL doses are too low. The doses you have are great if you assume 100% bioavailability but you're not going to get that.. I was not opiate tolerant and 1/6 of a 75mcg. was perfect for me; buccal.
 
I wouldn't drink with it mate. It's a very strong synthetic opiate and you have little tolerance.

What I would have done is placed a 1/16 of the patch on some foil and smoke it one toke at a time using the same method as you would 'spotting' heroin.

I did it with Fent this way and got a nice feeling. I find it is a safer way to dose something like this as it hits you prity much straight away and you can assess if you need more there and then. I have a fear that with an inexperienced user (no disrespect intended with that description, we are all inexperienced at some point) that if it's in your mouth you may take it out a little later than you should. Also if you are high when you take it out of your mouth you could handle it in a way that even more Fent gets into your system through your fingers. Remember that these patches are designed to get the drug in through your skin.

Just be careful really mate, is what I think we are all saying a round about way. You do sound like someone who is taking this drug seriously and it is refreshing to see compared to some on here.
 
Okay so how my night went: In a -lets say- 3 hours period I used half of my whole patch. I even chewed the last couple of pieces,. No euphoria, no sedation, nothing. After this i drank a beer and two scotch but i didnt want to continue the night because of my fear of the CNS depression. But, the other half remains for tomorrow:)

Glitched, you are saying smoking the matrix patch? I heard smoking plastic can cause serious brain damage. You did it the same way how people smoke the gel, by vaporizing?
 
no, do not smoke the polymer matrix adhesive patches because, yes, you will be smoking plastic.

were you swallowing your saliva by any chance when you had the patch in your mouth? you're meant to hold it in otherwise you're absorbing the fentanyl orally which has a low bioavailability of around 33% compared to 50% bucally.
 
I'm not sure about brain damage - it's not going to be healthy, that's for sure, but at least you can titrate your dose as Glitched said. Be very, very careful with fent - I know you didn't feel much before, but the doses are so small, it can be all too easy and deadly to overshoot..
 
Most Sincerely I would like to THANK YOU all of you people for your efforts and help my newbie questions:)

I finally ended up smoking little pieces (following this:http://www.drugs-forum.com/forum/showthread.php?t=148708 thread)
The effects are not quite what I expected, the euphoria is like what a high dose of tramadol gives. Eyes become heavy, a little bit like when you are stoned, The effects do not last long, the best part is whn it hits you ~10 seconds after inhaling.

Thankj you again, and have a nice sunday everyone:)
 
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