feeding Cacti iPhenethylamine Precursors

[Donbon]

Feeding cacti with:

folloving displayed molecyles
ESTRAGOLE:

Myristicin

And get a psychedelic!
Would this work?

With shrooms tryptamine analogs have been made by 4-hydroxy enzyme i think

Ill find link if you want me to

More:
https://www.synthetikal.com/psycoforum/viewtopic.php?t=45

 

[tathra]

i've hypothesized this sort of thing for a while, but never been able to get an answer either way.

you could hypothetically come up with some novel psychedelics that would be difficult to make in a lab setting.

 

[BilZ0r]

People do it... I'm not convinced that it helps. Most enzymatic converstions are under strict control.

 

[fastandbulbous]

You cant make cacti produce compound that they wouldn't normally make, but you can dramatically increase the levels of mescaline in the cacti by injecting then with a soln of 3,4-dihydroxyphenylalanine (L-DOPA). I've read that L-tyrosine also works, but that phenylalanine isn't much good (that sort of indicates that phenylalanine to tyrosine is the rate limiting step in mescaline biosynthesis).

You can't just inject it all in one go either, it has to be done about once a month (and using similat sterile techniques to prevent introducing fungal spores). I'll try and find the document I saved from The Hive with the details of somebody's experiments as it does work very well (I've tried it myself with fairly good results) - you can up the yeild up to 3x that found normally.

PS. The structure you gave as estragole isn't, it's eugenol (estragole is 4-methoxyallylbenzene)

 

[Donbon]

If its possible with mushrooms why not with cacti?

I dont see any research indicating that it should not be possible, i want to see some real experimentations, if someone said something along those facts science knows today, would be deemned crazy, but this have later been proved to be true. Im sure there have to be a way to make this with bio-syntesis, or hand me the prove.

I think someone should start experimentating, i know that im about it, but we need more resarch, to all bio-researchers with quick turn this out to be a full og dull, a very powerfull drug could emergen.

 

[fastandbulbous]

^ Because cacti (angiosperms - flowering plants) have totally different physiology to fungi. Fungi have a fair bit of metabolism in common with animals rather than plants (they contain chitin - normally found in insect exoskeletons and use glycogen as the storage carbohydrate, not starch that plants use) and are much more versatile.

In terms of enzyme substrates, there isn't a lot of difference between DMT & DET for 4-hydroxylation. If you're talking about getting cacti to produce anything other than mescaline or lophophine, then you're talking about different starting substrates to those normally encountered (2,4,5 substitution of the benzene ring is a LOT different to 3,4,5 substitution)

 

[BilZ0r]

but you can dramatically increase the levels of mescaline in the cacti by injecting then with a soln of 3,4-dihydroxyphenylalanine (L-DOPA)

Why do you say this?

 

[fastandbulbous]

Because it's fact. By increasing the levels of immediate precursors, you can utilize the cactus biosynthesis route to produce a higher than normal level of mescaline in the plant. I can't remember where I read it, but I've done it myself by injecting a cactus (T. pachanoi) with L-DOPA at regular intervals and extracting the alkaloids after harvesting it. I got a much higher yield than two other san pedros kept uner the same conditions (about double the norm); up to 3 or 4 times 'normal' levels of mescaline can be produced by this method in the hands of experts.

I most definitely do not have green fingers

 

[Donbon]

Sounds great

How about an enzyme-tank!

Its possible, someone posted something on the h*ve
PM me