These three are tied for first, it all depends on how im feeling, who im with, and what im going to do.
Molly+Lucy+Dmt - pure beauty and bliss. i only do this once a year at the right time.
Lucy+Molly+Ket - lets party!
Lucy at right dose - 200-250mics if im out in public, 300-400mics if im not.
but also, like moe. mentioned about mushrooms and the old friend reference is perfect. mushrooms have never asked anything from me, except to improve my life. they also helped me get over the loss of a loved one. mushrooms and i will always have a very special connection. so mushrooms are on a whole other level than just a psychedelic for me, they are the spirits of our earth.
dmt also is very amazing. but for me it is much more worth while to smoke while on lsd+mdma. universal love connection right there.