Ehm, there's a lot of favorites for me lol.
If I'm going for mainly uppers; I start off with MDMA with small bumps of ketamine then when I've almost fully come down start on amphetamines and GHB. I'll stop taking ketamine at this point. (Often I'll drink alcohol instead of taking GHB though because I usually don't bring any G.) I don't really ever bother with getting G eventhough it can be alot of fun. If I'm doing a combination of the aforementioned drugs, GHB is low priority since alcohol is always available and so I'll pretty much always settle for that.
If I'm going to be using psychedelics my favorite would be 2C-B I suppose. While I love everything about LSD I'm not overly fond of using it at a party unless we're talking festivals, I guess that's because I generally only trip on ~500µg+ doses, which can be pretty overwhelming when you're constantly standing in a crowd. Ideally, I'd combine either of these with MDMA and a bump of K here and there. Then alot more K when I'm coming down.
Purely downers; GHB is the winner here, but getting drunk on alcohol at a party can be pretty damn fun too from time to time. It's rare for me to only use GHB though, normally I'll always use amphetamines along with it. Alcohol on the other hand is usually the drug I use at "last minute" parties for which I haven't been able to cop any drugs, so in these situations it usually stays at only alcohol. I really like the effects of doing only GHB and the same goes for alcohol, but to a lesser degree since there's less euphoria and a terrible hangover. When I do this, I'll almost certainly feel like taking an upper after a while though because I'm getting tired.
Keep in mind that I'm not much of a party-goer anymore, barely even. I've calmed down alot during these past few years and barely ever go clubbing anymore. Right now I rarely use MDMA (about 3 times a year), GHB (3-4 times a year, maybe) or 2C-B (Haven't had any in like a year because I prefer LSD for tripping in other settings.) anymore.
I still get drunk once every month or two, but only socially. At a bar/someone's house where everyone is drinking. Never in excess anymore. I drink alone very rarely, and when I do it's no more than a glass or two of wine. Not for the effects, but for the taste.
I still use LSD and ketamine pretty often but nearly never at parties. Except when it's a mere bump of K here and there, but that ain't a full-blown experience, which is what I use ket for the most. Amps is another drug I still use more often than most other drugs and usually when I do I immediately go on a 3-4 day binge. Still, I don't use amps as much as I used to
at all, every month (or more) or so I still go on one of these binges but almost always for "hanging out" with a bunch of friends and getting tweaked. So it's almost never for partying anymore really.
From the 3 "options" I posted I prefer the 2c-b (or lsd) +other drugs combination above all others. I really, really
love psychedelics. :D But the other combos I mentioned are also sure to provide me with a very pleasant night at the club/other party, if I decide to go to one that is.