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Extracting diazepam from pill

T

thewalkrecords

Bluelighter
Joined
Nov 23, 2007
Messages
29
Hi everyone.

Well, I need some help with this:

I have plenty of pills which contains 2,5 mg diazepam and 100 mg chlormezanone. The thing is, I want to extract or filter the diazepam from the pills, mainly 'cause I've heard bud stuff about chlormezanone ("It was discontinued worldwide in 1996 by its manufacturer, due to rare but serious cases of toxic epidermal necrolysis" Wikipedia)

The pills are yellow, very easy to grind them into powder, but I don't have any clue of how take away the chlormezanone.

For information purposes only, I've taken up to 6 of this pills orally at a time (15 mg diazepam, 600 mg chlormezanone) and the effects are as anyone will expect from a benzodiazepine high, but I'm sure the chlormezanone is somewhat messing up the high in a bad way.

Please, if anyone have experience in this, I will be appreciate the feedback.
 
Anyone?

I know i't's a kind of a boring topic, but i'm stuck with this pills with 100mg of chlormezanone, and would love to get rid off it.

Thanks in advance.
 
I'd not want a vague chance of my skin falling off either! 8o

But realistically, you're going to have a job on separating them, both chemicals have similar solubilities, i.e. insoluble in water, soluble in chloroform, sparingly soluble in alcohol.
 
What about their solubilities at different temperatures? You could try fractional crystallization.
 
Thanks all for the replies.

Butane: I search for "fractional crystallization", and it looks a very difficult task. I don't have the knowledge and (I think) the implements to carry out complex chemical procedures. Thanks anyways.

At the moment, It appears I'll have to cope with the chlormezanone, and take the risks of suffer this biblical disease that cause the detachment of the top layer of skin from the lower layers of the skin all over the body. Shit. Sounds horrible.

I'm just expecting that the chlormezanone, at least, and specially considering the mortal risks involved, will boost the effects of diazepam in a good way.
 
It seems to be like you may be able to form a stable salt out of diazepam, making it more soluble in water.

Bring the pH of an alcoholic solution down low and wash it with some organic layer that will take out all the chlormezanone.

It looks like diazepam is soluble in ethanol and chlormezanone is hardly soluble in it anyway, so perhaps just a wash with ethanol will remove much of the unwanted junk. You'd need a good filter, though.
 
^ There's 40x more chlormezanone than vallium though (by weight, probably not far off by moles), and I doubt vallium is 40x more soluble in anything than chlormezanone.

You're not going to separate either without washing away most of the other.
 
I wasnt aware of that. I just read the two names and tried to figure out how to separate em.

You could always make the salt in an alcohol solution and wash out the chlormezanone with something else.


You can probably reduce the amount of chlormezanone by washing with minimal volumes of alcohol, chlormezanones solubility is pretty low in alcohol.
 
I've had chlormezanone (was use up until 1994 in the UK) and I liked it. The incidence of necrosis is still in the 1-100000 type range. If you look at the odds against other, everyday risks, then it's not THAT risky.
Of course, chlormezanone has that nice amine, so salting it out is the most obvious looking route. It's readily soluable in acetone, chloroform & DCM. Diazepam isn't soluable in acetone...

IA/B the non-dissolved part to be sure and there, I guess, you go...
 
Thats an amide, diazepam has that too.

I was talking about salting out the valium, as its got that secondary amine.
 
Imine, not secondary amine. I guess since valium survives your stomach, to the extent the iminium salt forms it must be stable.
 
Yes, the probaility of getting TENS is quite low, even with the drugs that cause it in high frequencies, but it isn't something I would play around with. It is bad--really bad. It often causes death and blindness--and future problems. You don't want to be the unlucky one that ends up with it...The best prognosis you can hope for if you get TENS is a reduced immune system, hyperpigmentation all over your body, disregulation diseases, a lack of energy, and really dry eyes (that will probably be so scarred in 20 years that you won't be able to see and contacts won't help unless you use eye drops every 20 minutes)--that is the best case scenerio. The worst case is perminent disability--getting your pores fused together, complete irreversible blindness, having your eyes so screwed up that you have to have all your eye lashes plucked out to keep them from scraping your cornea, or death. It doesn't stop after you leave the hospital. However, the probability is low because of the current theory of exposure--a person needs three coexisting events to get tens: 1) a genetic disposition for TENS. They think it is HLA associated. 2) Be taking a drug that one is allergic to. One must be exposed to it for either a few weeks or it could be a second exposure to allow for the adaptive immune system to become activated. 3) Have a virus at the same time.

However, people fuck around with that stuff all the time. I mean, many addicts continued to buy heroin even though there is a chance that some chemist fucked up and made MPTP, which causes parkinsonianism. Ick.

However, as long as you don't have multiple exposures you should be fine. If you are taking the drug on a daily basis it takes about 10-14 days for it to appear. It will also appear with a second exposure to a drug if there is a delay.

However, you would be surprised at the number of drugs that can cause tens. Most drugs on the market can, (from acetaminophen to ibuprofen to cocaine). However, the three most common drugs to cause TENS are Bactrim (and other sulfa drugs including lasix, celebrex, thiazide, ferosemide, etc...), Lamictal, and Modenifil.

I find it weird that this drug was taken from the market from just causing TENS. There are many drugs that cause TENS with a high frequency that are still on the market including the 3 stated above. Not only that, but they are still perscribed frequently--I mean how many of you have gotten a sulfa drug, lamictal, or modenifil perscribed? In fact, I think 25 percent of people are allergic to sulfa in some way--doesn't that justify removing it from the market--or at least not making it a first line antibiotic? Therefore, why was this drug withdrawn? Does anyone know how many cases of TENS were documented? Was it just that it was a crappy muscle relaxant so it didn't justify the risk?

However, I would just say forget about these pills. Is it really worth it? You will probably be fine, but do you want to chance it? I am sure there are easier ways to get diazepam.
 
SynAmnesia said:
I find it weird that this drug was taken from the market from just causing TENS. There are many drugs that cause TENS with a high frequency that are still on the market including the 3 stated above. Not only that, but they are still perscribed frequently--I mean how many of you have gotten a sulfa drug, lamictal, or modenifil perscribed? In fact, I think 25 percent of people are allergic to sulfa in some way--doesn't that justify removing it from the market--or at least not making it a first line antibiotic? Therefore, why was this drug withdrawn? Does anyone know how many cases of TENS were documented? Was it just that it was a crappy muscle relaxant so it didn't justify the risk?
Click to expand...

Yes, I agree with you. I don't get which was the exact reazon this drug was withdrawn in so many countries, considering that many others have a similar probability of provoke TEN. For example, I live in a country were chlormezanone is still available, and I believe the reazon is that there are not documented cases of chlormezanone related TEN ocurring here.

SynAmnesia said:
However, I would just say forget about these pills. Is it really worth it? You will probably be fine, but do you want to chance it? I am sure there are easier ways to get diazepam.
Click to expand...

Maybe the best advice. I'll try to get a prescription or something to get diazepam/valium. But still have these 25 pretty yellow pills, and I don't see myself flushing them in to the toilet. Never did with any drug. So, half serious, half joking, I promise to post if I start to get any TEN symptom.
 
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