• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Extended research on the startling effects of ULD Naltrexone

I thought that it was Naloxone in suboxone. The naloxone deters people from iv'ing the tabs - naloxone as far as I know isnt bioavailable orally - its subutex which contains Naltrexone. Please do correct me if im wrong.
The journal mentioned is by Mike Strates - it is very fascinating.
 
starfarer said:
I thought that it was Naloxone in suboxone. The naloxone deters people from iv'ing the tabs - naloxone as far as I know isnt bioavailable orally - its subutex which contains Naltrexone. Please do correct me if im wrong.
The journal mentioned is by Mike Strates - it is very fascinating.
Click to expand...

Suboxone is bupe/naloxone. Subutex is just straight bupe. The naloxone doesn't really do anything, and you can still iv the tabs. Naloxone is essentially pointless, and just a great way to keep the patent by reckett and not go generic.

Naloxone has a super low b/a oral and only lasts 30 minutes, plus it has a very low affinity, so bupe will just knock it off anyways.

Naltrexone is much nastier in terms of withdrawal
 
starfarer said:
I thought that it was Naloxone in suboxone. The naloxone deters people from iv'ing the tabs - naloxone as far as I know isnt bioavailable orally - its subutex which contains Naltrexone. Please do correct me if im wrong.
The journal mentioned is by Mike Strates - it is very fascinating.
Click to expand...

You started off right, but then went wrong.
You are correct that suboxone contains naloxone and not naltrexone.
You are incorrect that subutex contains naltrexone. It does not contain naltrexone or naloxone. Subutex contains only buprenorphine hcl. -DG
 
Not at all:
1. Find a pipette which will measure down to .5 ml (order from google shopping or get a syringe)
2.Cut pill in half and if you want in half again and drop into a 500ml bottle of water. Just leave it there for 30mins and it will dissolve into a loose mass at the bottom of the bottle
3.shake vigorously and extract 0.5 ml - hey presto you have 12.5 micrograms which is the recommended dosage (note the above directions constitute a 0.025 milligram per 1ml solution or 25 micrograms)

I have posted this on my blog which is linked and it is mentioned in other similar threads - I do wish people would look around a bit for information - no worries its here if anyone wonders the same thing and cant find the information out there. Good luck
 
oops. i actually thought naltrexone was another name for naloxone. so in my previous post, i meant to say "naloxone"

sry lol
 
Naloxone is iv only, and I havent really done any research (not sure if any exists) on using naloxone instead of naltrexone. If you are not already iv'ing I would advise that you just stick with the Naltrexone - iv is a slippery slope indeed
 
Forgive my question if it seems naive, does this suggest that the buprenorphine/naloxone combination in suboxone will reduce opioid tolerance as well or is the dose too high in suboxone preparations ? Has anyone tried this with methadone? Is there any reason that someone would think it wouldn't work with methadone? I've actually seen Jonathan Ott lecture before
 
Dont worry, better to be naive and well informed than naive and ignorant. Naloxone isnt active orally - the naloxone is to stop people mainlining it.
 
so i just wanted to put this out there... when I was a little younger I was prescribed to naltrexone to make my brain not want to cut anymore. Not until actually a few months ago did I actually look up the medication and realize what it is mostly used for. Anyone have any idea why they would put me on it for this reason?
 
^^ It would prevent you feeling 'endorphins', which are released in response to pain, and which could also contribute to the compulsion to cut.
 
I actually received the naltrexone during my 2 week vacation that I just came back from. To my disappointment, it is actually in the form of capsules :(. This means that I simply have to work with diluting all 4.5mg at once, and I am not sure I'm very comfortable doing that given my math skills.

Also, this is my 3rd week free of opiates, so not sure how useful my findings (if any) are going to be...

Will see what I can do today...
 
4500mics were dissolved in a 500ml bottle of mineral water. The bottle was shaken well. Using a syringe, 0.4ml was measured out in a syringe and taken rectally, which should equate to just around 3mics.

Wondering if I'll even feel anything subjectively. Although, I am considering a dose of codeine as I have a bad cold...
 
Good luck James Hyd Im hoping that you will be as dumfounded as I was upon discovering how potent this stuff is - I was using 12.5 mcg initially which resulted in maximum reduction ocurring in several weeks.
NLTX is bizarre however. Consider a scenario in which the NLTX candidate uses 12.5mcgt per day. Within several weeks the effects of this dose will have tapered off and one will begin to slowly and sublty creep up. Another titration coupled with a long break from the NLTX however will mirror previous results - this suggests that there is a tolerance pathway to the target effects. This makes sense ince opiate tolerance is homeostatic and it is likely that if some of the mechanisms are blocked the body may wel find a way to overcome the barrier.
My advice would be to use 1 week on and 1 week off. I myself am going to alternate between proglumide and naltrexone.
 
Interesting that you suggest 1 week on, 1 week off - as this is what my body suggested I do, and I have.

After I made the above posts, I maintained a schedule of 5mics 3X daily for a week. During that week, I experienced some bizarre events that may or may not be attributed to NLTX because it must be kept in mind that I am currently tapering down valium and am therefore in a constant state of benzo withdrawal.

Effects I experienced:
- Extremely sharp rise in libido on day 2, but it must be kept in mind that withdrawals from both benzos and opiates result in testosterone spikes.
- A mindblowing craving - not for codeine, but for things like Heroin and Poppy Tea!!
- My mood became very volatile.
- A trial with 200mg codeine produced full effects, confirming a complete reversal of tolerance (this was my starting dose). This however could very well be attributed to being 3 weeks clean.
- No effect, positive or negative, on Alcohol consumption.
- An apparently sudden loss of effectiveness for Bupropion, with the need to double the dose to 200mg 1X daily (SR). This, however, could be simple tolerance to the bupropion as I'd been using it for at least three months at the minimum dose.
- I did not get sick during that one week ;). (False positive I know, just thought I'd mention).

What will probably put NLTX to the test is whether I can maintain a 200mg dose of codeine as needed without the need to raise it, and whether I can keep to not taking it habitually.
 
now if only pharmausa would clear these combinations and manage the regular man's pain in a time relatively soon.. sadly we all know that wont happen for at least a few more years... here's to self managing by buying NLTX online :(
 
Well that does assume that NLTX is a wonder drug which is an easy enough misconception to fall foul of. NLTX is a great help but is not a panacea for opiate addiction. It will significanlty lower tolerance and delay addiction but both will bite the unwary on the bambini eventually.
 
Might try this.

I have been taking dihydrocodeine for a damaged knee joint for years, at 130mg/day, and up to 500mg/day occasionally, and I had tapered down slowly to 30mg/day, in two divided doses, but then had to go back up to 60-90mg/d thanks to a bastard of a toothache and need to do all that work all over again.

Think ULD NTLX might be worth a try? should it allow to go immediately down to 30mg/d again after a period of rapid tapering? what time scale is reccomended.
 
I would recommend having a look at my blog www.starfarer.wordpress.com which is just an extension of the posts I have set up regarding ULD NLTX. Everything there will answer most if not all of the questions anyone could possibly have, as I have detialed my experiences over several months of use there. My advice would be however not to expect immediate results. You should see a 70-90% (100% in rare cases) reduction in tolerance within -6 weeks with the recommended alternating week schedule.
 
Everyone responds differently to chemicals - that's the glory of mankind , our endless variance. The whole point of ULD NLTX is that it can be taken with opies without pitching a user into withdrawals. If however one manages to abstain and stay throughout the withdrawals and then takes High Dose NTLX for an extended period - according to the scientific literature their tolerance should fall.
Hope that helps - please though that question has been answered on the blog link as well as elsewhere - google is only a swing of a cursor away.
 
You must log in or register to reply here.
Top