starfarer
Bluelighter
NOTE: If you do use Naltrexone in small doses you need to decrease your opioid use. This is very important because it both potentiates and reduces tolerance. Staying on the same dose is counterproductive at any rate. For ULD Naltrexone to work you need to reduce your dose so that your tolerance can come down.
Obviation of opioid withdrawal syndrome by concomitant administration of naltrexone in microgram doses: two psychonautic bioassays.
Ott J.
Entheobotanica, Solothurn, Switzerland.
Abstract
Two psychonautic bioassays (self-experiments) in stepwise and abrupt cessation of long-term daily oral ingestion habits of 800 mg of codeine phosphate are presented. Concomitant administration of minute doses (about 0.5 mcg) of the opioid antagonist naltrexone with each dose of codeine was found in both cases to obviate the expected opioid withdrawal syndrome, resulting in asymptomatic and uneventful transitions from physical opioid dependency states to exogenous opioid-free metabolism. These experiments are analyzed in the context of a conjectured, rapid, iterative reduction and complete elimination of opioid tolerance, once acquired. It was found that coadministration of naltrexone with codeine phosphate obviated the development of both tolerance and physical dependency over several months of four daily oral doses of 200 mg, allowing abrupt ("cold turkey"), asymptomatic and uneventful withdrawal. This points the way to the biochemical substrate of opioid tolerance itself, and shows that this can easily and inexpensively be blocked, even over months of iterative oral administration of substantial doses of opioid analgesics. Finally, it suggests the opioid withdrawal syndrome is directly related to the physiology of opioid tolerance, and can be prevented by blocking tolerance itself. Even when tolerance has been acquired, this can be reduced stepwise over a matter of days, with no symptoms of opioid withdrawal syndrome.
The above article certainly piqued my interest. Over the last few months I have been using 12-15 micrograms of Naltrexone daily in order to reverse my tolerance. I have found that my tolerance has been attenuated by around 50-75% but not by 100% as this article so sincerely claims to be the case. The idea that NLTX could accomplish that is contrary to the chemical changes that are induced by excessive opiate use that is to say there are a multiplicity of different pathways and mechanisms.
The idea of stabilising one's tolerance as well as potentiating opiates is however a fascinating prospect - this article adds something new to what is quickly becoming something of a sensation - do you think it shows promise?
Obviation of opioid withdrawal syndrome by concomitant administration of naltrexone in microgram doses: two psychonautic bioassays.
Ott J.
Entheobotanica, Solothurn, Switzerland.
Abstract
Two psychonautic bioassays (self-experiments) in stepwise and abrupt cessation of long-term daily oral ingestion habits of 800 mg of codeine phosphate are presented. Concomitant administration of minute doses (about 0.5 mcg) of the opioid antagonist naltrexone with each dose of codeine was found in both cases to obviate the expected opioid withdrawal syndrome, resulting in asymptomatic and uneventful transitions from physical opioid dependency states to exogenous opioid-free metabolism. These experiments are analyzed in the context of a conjectured, rapid, iterative reduction and complete elimination of opioid tolerance, once acquired. It was found that coadministration of naltrexone with codeine phosphate obviated the development of both tolerance and physical dependency over several months of four daily oral doses of 200 mg, allowing abrupt ("cold turkey"), asymptomatic and uneventful withdrawal. This points the way to the biochemical substrate of opioid tolerance itself, and shows that this can easily and inexpensively be blocked, even over months of iterative oral administration of substantial doses of opioid analgesics. Finally, it suggests the opioid withdrawal syndrome is directly related to the physiology of opioid tolerance, and can be prevented by blocking tolerance itself. Even when tolerance has been acquired, this can be reduced stepwise over a matter of days, with no symptoms of opioid withdrawal syndrome.
The above article certainly piqued my interest. Over the last few months I have been using 12-15 micrograms of Naltrexone daily in order to reverse my tolerance. I have found that my tolerance has been attenuated by around 50-75% but not by 100% as this article so sincerely claims to be the case. The idea that NLTX could accomplish that is contrary to the chemical changes that are induced by excessive opiate use that is to say there are a multiplicity of different pathways and mechanisms.
The idea of stabilising one's tolerance as well as potentiating opiates is however a fascinating prospect - this article adds something new to what is quickly becoming something of a sensation - do you think it shows promise?
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I must however say that dosages do vary widely and the type of opiate in play may influence the NLTX dose. Mike Strates using Hydromorphone for example seemed to find his optiumum dose at 15mcg while Jonathan Ott using Codeine found 1mcg to be effective, whilst you are using 1-2mcg with H. It is a very inexact science as Ott and Strates found out, as there seems to be a wild fluctuation in response which requires adjustments to the dose within the 1mcg to 15mcg (i'd say 12mcg peronally) range.
