Explaining the afterglow 2#

[Dannlixi]

I recently developed HPPD* and I thought it might explain the afterglow of MDMA/other drugs, you know when you first take MDMA, after you've got over the comedown you still feel pretty good, like you have some new happy outlook on life, for me it last around 3 weeks after my first use, I probably took 300mg of unknown purity MDMA (it changed my personality so much some crazy homeless guy spoke to me while I was queuing for something in Tescos and normally I'd just ignore him but instead I was nice to him and treated him decently) although as soon as I started abusing MDMA I couldn't really feel any after-glow, it might have still been there just not as noticeable.

Now HPPD causes psychedelic visuals for long after the drug is out of your system and there are theory's that its caused by neuron growth at the 5-HT2A receptor (neuron growth at that receptor would mean that your brain functions like you're still on the drug since the drug has caused those receptors to grow), maybe the afterglow of MDMA is caused by the massive amounts of serotonin stimulating neuron growth at whatever receptors it targets.

If this is true low dose MDMA could be a new type of anti-depressant? like 5mg MDMA every 3 days or 100mg MDMA every three months to stimulate nerve growth and keep the afterglow, my HPPD lasted 6 months so it defiantly lasts a long time. Obviously this doesn't have to been done with only MDMA, I should imagine it could be done with any drug that stimulates activity of natural neurotransmitters, so you could try various releasing agents see which one you like and use it to stimulate that state of mind in everyday life.

I think this puts a logical explanation to the after-glow and also a positive to responsible drug use over no drug use at all. (not drug abuse)

I think I'm actually going to try it and post my results, I'm on St John Worts at the moment and it has helped a lot but I don't like the restrictions its had over my drug use, raves aren't as fun sober (but then again using MDMA at raves might ruin the after-glow schedule thing I would have to stick to)

EDIT - btw neuron growth isn't some bullshit idea I just made up its a valid scientific theory possibly fact I haven't looked into it

 

[JWills20]

I recently developed HPPD* and I thought it might explain the afterglow of MDMA/other drugs, you know when you first take MDMA, after you've got over the comedown you still feel pretty good, like you have some new happy outlook on life, for me it last around 3 weeks after my first use, I probably took 300mg of unknown purity MDMA (it changed my personality so much some crazy homeless guy spoke to me while I was queuing for something in Tescos and normally I'd just ignore him but instead I was nice to him and treated him decently) although as soon as I started abusing MDMA I couldn't really feel any after-glow, it might have still been there just not as noticeable.

Now HPPD causes psychedelic visuals for long after the drug is out of your system and there are theory's that its caused by neuron growth at the 5-HT2A receptor (neuron growth at that receptor would mean that your brain functions like you're still on the drug since the drug has caused those receptors to grow), maybe the afterglow of MDMA is caused by the massive amounts of serotonin stimulating neuron growth at whatever receptors it targets.

If this is true low dose MDMA could be a new type of anti-depressant? like 5mg MDMA every 3 days or 100mg MDMA every three months to stimulate nerve growth and keep the afterglow, my HPPD lasted 6 months so it defiantly lasts a long time. Obviously this doesn't have to been done with only MDMA, I should imagine it could be done with any drug that stimulates activity of natural neurotransmitters, so you could try various releasing agents see which one you like and use it to stimulate that state of mind in everyday life.

I think this puts a logical explanation to the after-glow and also a positive to responsible drug use over no drug use at all. (not drug abuse)

I think I'm actually going to try it and post my results, I'm on St John Worts at the moment and it has helped a lot but I don't like the restrictions its had over my drug use, raves aren't as fun sober (but then again using MDMA at raves might ruin the after-glow schedule thing I would have to stick to)

EDIT - btw neuron growth isn't some bullshit idea I just made up its a valid scientific theory possibly fact I haven't looked into it

Yes we've seen threads like this before providing some science for low-dose MDMA as an anti-depressant. The other threads also usually suggest that serotonin mediates serotonin neuron growth factor. However, no studies (that I know of) have been conducted into the use of low-dose MDMA in a clinical setting. Perhaps we are either missing key contraindications to the study, or it just hasn't been thought of and effectively conducted. Many are skeptical about the use of MDMA in a clinical setting so that's probably why.

 

[Dannlixi]

Yes we've seen threads like this before providing some science for low-dose MDMA as an anti-depressant. The other threads also usually suggest that serotonin mediates serotonin neuron growth factor. However, no studies (that I know of) have been conducted into the use of low-dose MDMA in a clinical setting. Perhaps we are either missing key contraindications to the study, or it just hasn't been thought of and effectively conducted. Many are skeptical about the use of MDMA in a clinical setting so that's probably why.

I've done some more research and apparently the after glow is down to 5HT2A receptor down regulation, supposedly SRRIs do the same thing, still going to try it though, 80mg of pure MDMA+tons of anti-oxidants every 3 weeks with some Lions mane mushroom daily, apparently thats stimulates NGF.

The after-glow will hopefully stay that way, I'm on DXM to prevent addraell tolerance so MDMA tolerance shouldn't be a big deal, I'm positive NMDA-antagonists have more anti tolerance purposes than just some dopamine receptors (like some serotonin and GABA), I won't take them at the same time though.

 

[Deleted member 290563]

Serotonin releaser? Vs reuptake inhibitor?

ARe there currently any antidepressants whose mech of action is Serotonin release by transporter opening? I think most anti depressants work by closing off the re-uptake proteins. with MDMA you would have serotonin being released by the transporter (or protieins responsible for release to of 5-ht to the synaptic cleft). different mechs of action, don't know of any current antidepressents that utilize mdma;s mechanism of action.

 

[Dannlixi]

ARe there currently any antidepressants whose mech of action is Serotonin release by transporter opening? I think most anti depressants work by closing off the re-uptake proteins. with MDMA you would have serotonin being released by the transporter (or protieins responsible for release to of 5-ht to the synaptic cleft). different mechs of action, don't know of any current antidepressents that utilize mdma;s mechanism of action.

aMT & aET were used in the soviet union I believe but they had problems so they were discontinued, weather or not they work like MDMA I'm not sure. I wouldn't be taking it everyday just every three weeks