...Some cheap ass RC? Please refrain from insulting my intelligence with such condescension, I am not some uneducated kid when it comes to psychedelic drugs, I've tried all of the substances you've mentioned more than once. I chose 2c-e because it is my favorite psychedelic for a variety of personal reasons, and my mom and I have a lot in common and I think she would agree. Mescaline did not even come close to my favorite psychedelic, and by the way this isn't some ceremonial family thing.. I just thought a psychedelic like 2c-e would be therapeutic for her current life issues, I discussed with her fully the effects and side effects profile of the drug. She's also dosed acid several times so I'm not worried about her needing a "gentle introduction" to psychedelia.
Sorry if that was a little inflammatory, but I put a lot of thought into this choice, it's a little insulting to be accused of giving my mom a cheap ass RC.
Whoa whoa, slow down. I wasn't meaning to insult you. I must've misinterpreted your intentions and my advice was well-meant. I do love 2C-E for the biographical insights it gave me and the emotional impact of the experience. I thoroughly enjoyed high doses of DOC, eventhough it left me stimulated for many hours after the psychedelia wore off. That being said, I think you might not have dosed mescaline properly. Dosing crystalline mescaline is very different from eating cacti. It kicks in faster, for me it's in the 10-15min range opposed to 2h for cacti. It also has a very steep dose-response curve, amounts around 500mg almost seem like providing sort of a breakthrough experience with full blown visuals that are not affected by closing/opening my eyes, similar to what dmt does. Hardly any other psychedelic has ever brought me close to such a magical state, not with such a high reliability anyway.
i think the easiest way to alter someones opinions on psychedelics is to give them a light trip; but this means taking them on as a responsibility, which can cost too much of your own energy
I personally have always recommend ridiculously high dosages for psychedelic-naïve people. Since that is not in the spirit of this forum though, I'll abstain from arguing against your opinion. For me low doses have never been as rewarding and also posed larger risks of things becoming worrysome. Like the difference between climbing a waggly ladder and sky diving if that makes sense. The closeness to reality brings my fears closer as well.
i think i saw your picture below an article ?? saved by the DMT elves ?? if that was you, grats on full recovery !!
Yeah thank you lol, that was in Hamilton's column in the ViCE. :D There used to be an (imho) amazing thread here on bluelight that unfortunately got deleted after reaching the fourth page in notime. I posted about the accident on several forums and the responses I got here were completely different from the shit I got from people on other boards. I totally fell in love with this community reading all the understanding posts and the well-meant advice, one user even offered free legal help to me! I never understood why it got deleted, it was clear the German authorities were looking into it already and I didn't further incriminate myself. It was one of the finest examples of harm reduction the site had seen, if I may say so quite humbly.
Mods also deleted the picture of my collection back in 2006, in case you remember that one.
Also, learn some basic organic chemistry (how psychedelics function) before you say something is good for you because it is natural.
I really need to learn how to convey irony through teh internets lol. I was saying that in a way that Bart Simpson would conclude Slushies are good for you because they come in blueberry flavor and blueberries are fruit so slushies are good for you.
That being said, mechanisms alone aren't what make up the perceived effects of a drug and it's subtle differences from other substances of the same class. There are a lot of pharmacokinetic aspects to be taken into considerations on top of which receptor is the main target of the substance. The unique shape and chemical properties of a molecule can account for different absorption routes being preferred even through the same route of administration, different distribution in the body, easier passing through the blood brain barrier, different enzymes playing a role in metabolization, binding to other receptors on top of the main target which could lead to anything from a slightly different duration to a whole different character of the experience being perceived.
DMT provides a very different experience from the one mescaline provides, yet they both are very strong agonists on 5HT2A-receptors, which is considered the primary mechanism by which the psychedelia is caused from what I know. Another great example would be comparing fentanyl to morphine, both using the same mechanism yielding very different results for the individual and society as a whole. Ethanol and IPA share the same mechanism of action from all I know, one will dissolve the cell membranes of the epithelial tissues in your GI tract a lot faster than the other though (incidentally, ethanol which does so to a much lesser extent than IPA is natural, but I still wouldn't say it's good for ya, considering the consequences of drinking for the individual's health and the psychosocial constructs he moves in, especially with it's main metabolite acetaldehyde which possesses a much larger toxicity than IPA's main metabolite acetone).
Anyway, I'm sure you know this stuff and know what I'm aiming at, yet I'll name another curious example. While 5HT2A-receptors are considered the main mechanism through which the psychedelic experience is caused, these receptors are also present on the cell membranes of muscle cells, where some 5HT2A-agonists can cause a state known as malignant hyperthermia. There have been no cases of LSD-induced malignant hyperthermia though while MDMA is known to cause it in individuals that are prone to it. If we aren't entirely on the wrong track when it comes to both psychedelic effects and malignant hyperthermia, then this example demonstrates yet again how even through the action at the same receptor, different effects can be caused.
I still hold onto my experiences with mescaline and it's superiority over any rc's I've encountered when it comes to the potential emotional and spiritual impact of the experience.
This was a bit of a ramble I suppose, but I won't stop before I thank you kindly, !!4iV4HF9R34g, for your well-meant advice suggesting I ought to learn "some basic organic chemistry". I'll most definitely consider it, eventhough I think books on neurophysiology and biochemistry would bring me closer to the subject in question. ;P
