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Experiences using LSD with SSRIs

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psytaco

Bluelighter
Joined
Nov 20, 2005
Messages
1,673
Location
Melbourne, Aus
The doof season is apon us and I was wanting to trip a little at a very large doof at the end of january;). The problem is I take SSRIs (zoloft 50mg) for depression/anxiety and I am worried about there been a dangerous reaction.

I have read the thread on bluelight about the interaction being fine. However, a bit over a month ago I ended up having a serotonin syndrome as the result of mixing my medication with half a pill (believed to be DXM). As LSD works heavily on serotonin, I am a bit worried about using it. Also, some of the more medical orientated literature says LSD can lead to serotonin sydrome when combined with SSRIs. However, it says this about many substances that I have tried with SSRIs and had no negtaive effects.

Has anyone here had any personal experience or know people who have had experience with using LSD whilst on SSRIs?

I am mainly interested in any negative effects being felt whilst tripping and on antidepressants. I am not planning on tripping hard, just a light to moderate trip (best for festivals).
 
Zoloft i dont think you stand a chance of tripping much.
Prozac... yeah.. ive heard of people still being able to trip.

You may need more than usual if its going to work, and i'm sure there will be a fair bit missing from the experience but please make sure it is LSD and not dragonfly or 2cb-fly or DOX's chems...
 
ShitKebab said:
Zoloft i dont think you stand a chance of tripping much.
Prozac... yeah.. ive heard of people still being able to trip.

You may need more than usual if its going to work, and i'm sure there will be a fair bit missing from the experience but please make sure it is LSD and not dragonfly or 2cb-fly or DOX's chems...
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That last bit is good advice. Completely forgot about adulterants.

BTW, why do you think zoloft won't work but prozac will? they are pretty similiar from my understanding.
 
Zoloft is pretty strong right? It smacks some people about hard
While prozac is pretty tame at 20-60mg

All i know is most people do not get high from psychedelics or MDXX on SSRIs.
But i have mates of Prozac that say they still work fine.
One mate says adding prozac cap to an MDMA dose makes it a lot "cleaner" and even stronger and a longer experience. I dont really have anything to back his theory up.
 
ShitKebab said:
Zoloft is pretty strong right? It smacks some people about hard
While prozac is pretty tame at 20-60mg

.
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Zoloft depends on the dosages. Any SSRI taken at large dosages has the potential to have alot of side effects. Most of these go away after a month or so. I feel pretty normal on zoloft now, and have very few side effects. But I'm taking a pretty low dose for my size.

Can't speak for prozac as I haver never taken it. I was of the impression that SSRIs generally have very similiar theareuptic effects, its just a matter of what side effects you can tolerate:\
 
I have a few friends who take zoloft. Each dosed 99.9% pure molly, high mdxx beans, awesome acid and oxys and didnt feel a damn thing. Used all of them and it floored me. Dosing Zoloft will def decrease or even cancel out most drugs.
 
My little brother did it; he took about 1.5x his dose and had a great time; but he doesn't really have anything else to compare it to and has since quit drugs and gotten on even more serious meds (unfortunately the LSD did not agree with his worldview and it kind of spun him out into this existential uncertainty that seeped into all aspects of life.)

SSRIs seem to have variable effects on psychs & empathogens but genuinely dampen it, but they shouldn't have an effect with oxy, that doesnt' seem to add up to me

& I still love this word:

psytaco said:
doof
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psytaco said:
doof
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psytaco said:
doof
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Sustanon said:
I have a few friends who take zoloft. Each dosed 99.9% pure molly, high mdxx beans, awesome acid and oxys and didnt feel a damn thing. Used all of them and it floored me. Dosing Zoloft will def decrease or even cancel out most drugs.
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Anecdotally I can attest to this too. Zoloft bluntened the effects of both LSD and MDMA for me far more than Lexapro, Effexor or Avanza (mirtazapine). I can't remember the exact doses of each I was on though sorry. (Disclaimer yes I know exactly how irresponsible it was to take those drugs while on said antidepressants - self preservation wasn't a high priority at the time).
 
belarki said:
Anecdotally I can attest to this too. Zoloft bluntened the effects of both LSD and MDMA for me far more than Lexapro, Effexor or Avanza (mirtazapine). I can't remember the exact doses of each I was on though sorry. (Disclaimer yes I know exactly how irresponsible it was to take those drugs while on said antidepressants - self preservation wasn't a high priority at the time).
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These types of threads make me scratch my head...... but each to their own i spose! :\
 
Sustanon said:
I have a few friends who take zoloft. Each dosed 99.9% pure molly, high mdxx beans, awesome acid and oxys and didnt feel a damn thing. Used all of them and it floored me. Dosing Zoloft will def decrease or even cancel out most drugs.
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That is interesting. MDMA not working makes sense, as does the acid not working too. But I can attest through experience that opiates work perfectly fine with zoloft. maybe the combo blocked it?
 
Wasnt in a combo they were all taken separately. Dont know if u are an exception or an extreme case but i know for sure that they felt very little from oxys, ms contins and h. Some of them have low tolerance to opies as well.
 
taita said:
These types of threads make me scratch my head...... but each to their own i spose! :\
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Yes, I'll admit if you're on an anti-depressant you should seriously consider whether you're in the right frame of mind to be taking psychadelic drugs in the first place. In my case though it'd be hypocritical to lecture those who chose to do so... :\

In hindsight I'd say skip the acid. Get yourself in a better mindset regarding your anxiety & depression first. There's nothing wrong with attending a doof/rave sober after all :)
 
belarki said:
Yes, I'll admit if you're on an anti-depressant you should seriously consider whether you're in the right frame of mind to be taking psychadelic drugs in the first place. In my case though it'd be hypocritical to lecture those who chose to do so... :\

In hindsight I'd say skip the acid. Get yourself in a better mindset regarding your anxiety & depression first. There's nothing wrong with attending a doof/rave sober after all :)
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yeah I do appreciate that, and ordinarily I would agree. However, I can't say I have felt 'depressed' for over a month. I am planning on tapering off the zoloft in a few months anyway.

Further, I have tried on LSD a few times after being diagnosed with depression, prior to taking SSRIs and if anything it allowed me to gain some more insight into myself. At the least it let me have a day of fun and a day free of feeling like shit.

I've pretty much cut back on all drugs and booze, just drink now and then atm, maybe with a little bit of speed. so I feel entitled to have a bit of trip considering my headspace has been better than it has been for a longtime.
 
It still works.

LSD effects slightly diminished.

May need to dose 1.5-2x your usual dose.

Consider your current headspace and filling it with a powerful psychedelic drug (set & setting)

SSRIs make MDMA pointless but you can still trip.

I haven't taken SSRIs in well over a year at the very least and don't plan to ever use them again!
 
8L4YN3 said:
I recall once as a youngin i went to a friends house to buy some xanax and all he had was "zoloft", at the time i figured it was atleast something recreational.... Man that was a disapointing night...

end obsecure story/
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haha. I've read on erowid stories of people trying to use zoloft recreationally. Almost all of them have ended in disappointing or uncomfortable experiences. When you first start taking the stuff you feel like SHIT! Nausea, diahoerra, shaking, scatter brained. takes a good week or so before the side effects leave and then you feel good.

alot of the guys try high doses too, alot higher than the max theareputic dose. I imagine you would spend most of the night burning up and trying to stop yourself shitting and spewing everywhere.
 
Zoloft has no recreational value at all. Hence why it is used to treat for a long period of time with no potential abuse or major WD's.
 
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