^^No, if taken sublingual then the nalaxone is only just barely absorbed,if at all. However you will go into withdrawals from the buprenorphine (with or without the nalaxone) if you take it while there are other opiates still attatched at the receptors (the longer u wait the better, especially w large habits). This is because buprenorphine binds to the receptors much tighter than other opiate/oids and if your tolerance to those opiates is higher than what bupe can do at its ceiling dose it's going to make your withdrawals worse. That's why people with larger, longer habits have a harder time switching, like waiting longer, and are actually still somewhat sick the first couple days on bupe maint bc it takes a few days for there tolerance to drop below what the ceiling dose of bupe can do.
I think the nalaxone is somewhat active when IVd, not to the extent the Drs and such would have you believe, but more so than i see it getting credit for here. In my experience, and from my understanding of the difference in the time each drug takes to cross the blood brain barrier, nalaxone crossing much faster than bupe. I've also read that, while nalaxone has a VERY difficult time undoing bupe, BUT, if the nalaxone is there first it is hard for the bupe to unseat the nalaxone. Also if one is using low doses of suboxone there might not be enough bupe to saturate the receptors leaving some open for the nalaxone. Plus most IV users say subutex reels much better than suboxone. I personally have never IV'd only buprenorphine, always suboxone film.
This mimics my experiences with IVing suboxone strips. I will always inject low doses usually .5mg spaced out 8 to 12 hours or whenever I start to feel sick, so there is room on the receptors for nalaxone. Also when I inject it I notice I feel slightly off, like anxiety, slightly increased heart rate, lil hot n sweaty for the first ten min or so n then after 30min or so I feel much better, i think its bc the nalaxone has worn off as it has a very short half life, and the bupe takes over everywhere. I also notice that if I do any shots before the effects of the bupe has worn off, i.e. not sick, I do not feel the ill side effects as there is already bupe there blocking the nalaxone, only allowing more bupe in, resulting in me getting that feel ”goodish" much quicker, like 5/10 minutes.
Anyway... I seen the Dr, good dude, seen me at like 7pm and i had only just called this morn. I said I was using sporadicaly or getting by on 1 or 2mg a day iv sub film, so of course he Rx's me 16 mg a day burenorphine only gummies from a compounding pharmacy. They still don't get it, even the cool docs don't know what all we know. When I get the gummies I'll update with my thoughts
BUT I still want to hear what other people, who have actually had experience or legit knowledge on the type, have to say about the gummies as far as effectiveness, ease of dissolving, alternate roa, maybe someone has a technique for snorting. I doubt these could be anywhere near safe to iv, probably exponentially more dangerous than the strips, who knows maybe not. I have always wanted to try iv bupe by itself but I doubt even I could bring my self to IV a gummie. I'll post the ingredients if I can get the pharmacist to give them up, and maybe someone smarter than me would know what kind of solution they would break down into. Until then I'm 'scribed 16mg daily so I'll have more than enough to take them properly and get the same dose I was from iv, with even better duration. My main reason for IVing the strips was bc they were off the street and I could make so little go so much further thru iv, a major concern due to price and availability. I am very happy this is solved through the massive script, very tired of injecting nasty bupe/narcan.
Gummie experiences below please.
