JohnBoy2000
Bluelighter
- Joined
- May 11, 2016
- Messages
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A lot of literature contends it doesn't, but I wanted to do a comprehensive'ish personal review on this.
As a preface, it's common knowledge that melanotan 2 and it's close analogue, Bremelanotide - DO readily cross the blood brain barrier.
However, due to the contention Afamelanotide is a bigger molecule, it apparently doesn't.
Afamelanotide:
Molecular Weight 1646.8 g/mol
a polypeptide comprising of 13 amino acids
Melanotan 2:
Molecular Weight 1024.2 g/mol
chain of 7 amino acids
.......
MT1 doesn't seem THAT much bigger though....?
As a preface, it's common knowledge that melanotan 2 and it's close analogue, Bremelanotide - DO readily cross the blood brain barrier.
However, due to the contention Afamelanotide is a bigger molecule, it apparently doesn't.
Afamelanotide:

Molecular Weight 1646.8 g/mol
a polypeptide comprising of 13 amino acids
Melanotan 2:
Molecular Weight 1024.2 g/mol
chain of 7 amino acids

.......
MT1 doesn't seem THAT much bigger though....?