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Ethanol and amphetamine neurotoxicity?

I dont know if theres any cocaine+alcohol type reaction.
But I can think of two neurotoxic substances combined can't be good, especially a stimulant that causes neurotoxicity and doesnt let you sleep through the hangover on a brain damaging drug. Some of the worst comedowns ever. A migrane and meth psychosis! yay
 
Alcohol hangovers are indeed the worst when on amphetamine. I generally attribute that to being able to drink obscene amounts of alcohol when on speed though.

I too would be more than interested to find out if (and how) this combination increases the risk of neurotoxicity.
 
In methamphetamine (MAP) addicts, long-term ethanol ingestion 3–4 times per week induced an increased rate of p-hydroxylation of MAP and amphetamine (AMP). Simultaneous ingestion of ethanol and MAP inhibited both p-hydroxylation of MAP and AMP and N-demethylation of MAP in inebriated addicts. The p-hydroxylation of MAP and AMP was also significantly inhibited in daily drinkers despite the almost total absence of urinary ethanol. This suggests that the intensity of MAP-induced behavioral and psychological effects in MAP addicts may, in part, depend upon their drinking habits.
http://alcalc.oxfordjournals.org/cgi/content/abstract/23/5/351

Summary Ethanol, 3 g/kg i.p., did not significantly alter the acute toxicity of amphetamine in the mouse. However, the urinary metabolite pattern was changed, suggesting that ethanol suppressed metabolism of the stimulant during the initial 6 h period. After 24 h, the mouse metabolized the same fraction of a given dose of amphetamine, whether it was given as amphetamine alone or amphetamine mixed with 2, 3 or 4 g/kg ethanol.
http://www.springerlink.com/content/u34j77422q7r6k48/
 
Splatt said:
I dont know if theres any cocaine+alcohol type reaction.
But I can think of two neurotoxic substances combined can't be good, especially a stimulant that causes neurotoxicity and doesnt let you sleep through the hangover on a brain damaging drug. Some of the worst comedowns ever. A migrane and meth psychosis! yay
Click to expand...

There is no cocaine + ethanol like reaction because amphetamine does not contain an ester. Amphetamine and methamphetamine do not cause the same type/degree of neurotoxicity, so equating them is not proper in this case.
The metabolites of amphetamine include 4-hydroxyamphetamine, beta-hydroxyamphetamine, and to a lesser extent 4, beta-dihydroxyamphetamine, phenylacetone, phenylacetic acid, and hippuric acid.

Although ethanol may alter amphetamine metabolism by a number of different ways, these effects are largely insignificant. The main issue involves consuming large amounts of a seditive along with large amounts of a powerful CNS stimulant, and any subsequent cardiovascular effects.

In short, low doses of both drugs used together on a non-repetitive basis should present little in terms of neurotoxicity.
 
^ Woah!! Now thats a new on! (ethylphenidate). Why isn't this more well-known?

As for the OP... well, Alcohol is inherently neurotoxic, and Amp. is so too (supposedly). So 1+1=2 ;)
 
I've had the journal article about ethylphenidate for a couple of years now. I had no idea it wasn't well known. Ethylphenidate has a higher DARI/NERI ratio than methylphenidate. Anecdotally, methylphenidate and a couple of beers is pretty nice!
 
Abusing amphetamines increases the permeability of your blood brain barrier and allows more foreign substances to cross it.

Whatever thats worth!
 
Single methylphenidate can be quite anxiety provoking in me sometimes, but after a few beers that has usually molten away. Is it just the hypnotic effect of EtOH, or can ethylphenidate have something to do with it?
 
There is no cocaine + ethanol like reaction because amphetamine does not contain an ester.
Click to expand...

Amphetamine doesn't react in vivo with ethanol but it does with its metabolite acetaldehyde:

(From TiHKAL)
1,3-dimethyl-tetrahydroisoquinoline - Not reported in cacti. When amphetamine is fed to rats and chronically exposed to alcohol, this is formed. It is quite neurotoxic, it causes tremors, and it produces a Straub tail response.

Other odd acetaldehyde reactions:
1-methyl-1,2,3,4-tetrahydro-beta-carboline, 3-carboxylic acid - The reaction between the amino acid tryptophan and acetaldehyde produces this toxic compound.
Harmalan - Harmalan levels reflect the consumption of alcohol. Acetaldehyde is a metabolite of ethanol, and readily condenses in vitro to yield harmalan. However, a second biochemical role of acetaldehyde is to inhibit the disposition of pyruvic acid, a material which reacts with tryptamine to give tetrahydroharman-1-carboxylic acid which on decarboxylation and sequential dehydrogenation gives rise to the beta-carboline cascade, tetrahydroharman, harmalan and harman.
 
Recept said:
Alcohol hangovers are indeed the worst when on amphetamine. I generally attribute that to being able to drink obscene amounts of alcohol when on speed though.

I too would be more than interested to find out if (and how) this combination increases the risk of neurotoxicity.
Click to expand...
The worst hangover imagined was produced with Tenuate (time release Diethylpropion) and beer. Got home around midnight, headache started about 12:30. Unable to sleep until after 4:00 A.M. Alarm goes off at 5:45A.M with work at 7:00 A.M.

(Tenuate is a low euphoria stimulant rated between Ritalin and Caffeine on the "Willie Amphetamine / Morphine Liking Scale".)

Speed and alcohol is usually a mistake unless you can stop at a couple of beers.
 
Great news Nuke! Whenever the amph. has entered my body the last few years alcohol has too. Maybe explains the slight tremor developed a summer or two ago. :\ :D
 
Amphetamine metabolism acetaldehyde

Hi,

I would like to know if there are any Studio about the metabolism of acetaldehyde of etanol, cause from amphetamine action.

With Ampetamine, not, metanphetamine...

Thanks for all and congratulations for this place.

Un saludo desde Mallorca,
Cain.
 
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