Ethanol and amphetamine neurotoxicity?

[Cainuriel]

Amphetamine doesn't react in vivo with ethanol but it does with its metabolite acetaldehyde:

.

Nuke, Do you have any Studio that Confirm this afirmation?

Thanks,
Cain.

 

[Ham-milton]

Nuke, Do you have any Studio that Confirm this afirmation?

Thanks,
Cain.

None is really needed. The reaction occurs where there's an ester- as there isn't, it can't occur. a beta-ester amphetamine in all likelihood would.

 

[Cainuriel]

Thanks for the quickly answer.

Yo say me:

"None is really needed. The reaction occurs where there's an ester- as there isn't, it can't occur. a beta-ester amphetamine in all likelihood would"

Who as occurs the beta-ester inside of humans?

I ask this cause I try to Know a question.

Hangovers (Sorry for my english I am from Spain), is produced by an excess of acetaldehyde... Not?

People that take Speed (In spain Speed is sulfate of Amphetamine) say that no have alcohol hangovers

My teory is that for any reason the amphetamine metabolised the acetaldehyde.

That is posible with this beta-ester amphetamine?

Thanks again,
Cain.

 

[Cainuriel]

None is really needed. The reaction occurs where there's an ester- as there isn't, it can't occur. a beta-ester amphetamine in all likelihood would.

Or an aceleration of the catabolics reations with the amphetamine, that metabolised the acetaldehyde more faster that a body without amphetamine...

What you think about?

 

[Ham-milton]

none of those reasons sound remotely likely, though if we were both speaking in our native language, we might have a better chance of understanding eachother.

 

[Cainuriel]

none of those reasons sound remotely likely, though if we were both speaking in our native language, we might have a better chance of understanding eachother.

Cain:
ufff, in my language? .... ok...

El acetaldehido es la causa de las resacas, ok?

well,

los consumidores de Speed no tienen resaca de alcohol, en su gran mayoría.

Yo me pregunto porqué.

las razones serían:

1º Inducción enzimática que metabolizase más rápido el acetaldehido...

2º Reacción de las anfetaminas con el acetaldehido, que tu me has dicho que no.. ...ya que se necesita una beta-ester anfetamina... no?

I hope that you can understand me, but yo think that is impossible to
accelerate the metabolisme of acetaldehido with amphetamine?

Thanks for your patience...

Cain.

 

[Ham-milton]

Cain:
ufff, in my language? .... ok...

No, I meant that if we were both able to communicate in our native languages (and be understood as if the other was hearing in theirs), we'd probably understand eachother better.

Unfortunately I wasn't able to understand a word of that.

Well, speed and alcohol I got

Anyway, while there is a great deal made of stimulants ability to simply 'speed' all bodily processes, I don't think there's much to it. Perhaps someone a little more knowledgable can chime in here, but I think any sort of enhanced metabolism of acetaldehyde is probably minimal enough that it doesn't offer any protective benefit.

I can't really think of any potential mechanism by which amphetamine could protect a user from the adverse effects of a heavy night of drinking, but I'm sure someone out there has a good idea.

Maybe the enhanced metabolism is the correct answer. I'm not sure.

 

[Barkuti]

Little help with translation,

Hi guys,

A little translation for Cainuriel's questions, I think I can understand what he's trying to ask and put it in the standard language:

Translated quote.

Acetaldehyde is the main factor in hangover nastiness, isn't it?

Well, the majority of speed users don't suffer from hangovers.

I ask myself why. Possible reasons:

1. Enzimatic induction which metabolizes acetaldehyde faster.
2. Anfetamine reaction with acetaldehyde, which you said wouldn't happen... because a beta-ester amphetamine is required.

Hope you can understand me. Do you think a speed-up in acetaldehyde metabolism is just not possible with plain amphetamine?

Thanks for your patience.

Cain.

As I see it, the accelerated metabolic rate under the influence of amphetamine may contribute for a higher metabolization rate of alcohol, just by the general speedup in bodily processes. Maybe I'm just telling bull...

...or it could be that speed runners soon learn how hard of an alcohol hangover one can get while high on amph, due to the much lesser perceived/manifested side effects from booze, and due to this they take an effort to slow down their drinking rate and/or learn to observe different signs of alcohol intoxication...

...a combination of both factors.


In the right dosage, being drunk while on amph is quite pleasurable.
Sometimes being a speed runner, I do find correlation between amount of alcohol ingested, intake timeframe and subsequent hangover; altough little, there will always be some discomfort unless you drink little and/or stop doing it early.

Doing some amph at the end of the binge will ease off the pain (you'll still be amph-high while your body fully metabolizes the alcohol). This will prevent you from sleeping tough. Great if you have to work that morning after clubbing. I've done this many times.

And let's not forget it's veeery important to take supplements and have a good meal after the binge, before going to bed. Many people don't do this and later complain because they feel like shit when they get up after a speed binge.
Quite obvious, you're depleted off nutrients. You need fresh raw materials for repairs while you're asleep.


Wow. I should be sleeping now. 8)


Cheers

 

[fastandbulbous]

Well the condensation product of acetaldehydr & amphetamine (or methamphetamine) are 1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline & 1,2,3-1,2,3,4-tetrahydroisoquinoline respectively and from what I can remember while researching possible ring condensed (conformationally restricted) amphetamines, 3-methyltetrahydroisoquinoline & it's brethren are rather nasty compounds re toxicity etc. Cant remember why, but it was enough for me to reject them as a further area for investigation

 

[Cainuriel]

Say me:

"I can't really think of any potential mechanism by which amphetamine could protect a user from the adverse effects of a heavy night of drinking, but I'm sure someone out there has a good idea.

Maybe the enhanced metabolism is the correct answer. I'm not sure."

Cain:
I Think So. The Enzimatic induction causes for amphetamine may be... not?

Thanks for your answers.

Cain.