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Entactogens/Entheogens of the Future.

Just forget it.

You know, maybe I got the dosage wrong, but I guaarawntee you they are both psychoactive.
 
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What about 2-methoxy-5-methyl-3,4-methylenedioxyamphetamine?

2-MeO-MDA, 5-MeO-MDA, 2-Me-MDA, 5-Me-MDA and 2,5-diMeO-MDA are all active, so im curious about other analogues exploring that direction, looks like theres lots of potential for novel compounds with empathogenic and hallucinogenic effects, which seems to be a popular effects profile. Also i found a french paper referring to MMDMA or 5-methoxy-3,4-methylenedioxy-N-methylamphetamine as being a "drug of abuse" which suggests its been found on the street somewhere although i've never heard of it anywhere else...

Or maybe 2,3-methylenedioxy-4-bromo-5-methoxyamphetamine...probably more of a pure hallucinogen but should still be active. Lots of promising substitution patterns that have never been tried.
 
samadhi_smiles said:
I have nothing valuable to add except to say this thread has given me a very negative feel.

Breathe.......smile, everyone.

:)
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Empathogen experiments not working out, clearly. Or perhaps they're all on comedowns :\ !

Anyway - perhaps a indanyl-piperidine/morphonline empathogen.
Basically a 2-(3,4-methylenedioxy)benzyl-piperidine, but with the oxygens replaced by CH2's. From what I understand this increases the selectivity for SErT. The ratio of 5-HT to DA and NE efflux and reuptake inhibition would hopefully be suitable for euphoria - too much 5-HT, and not enough DA and NE, and it's crap.
 
fastandbulbous said:
The 'acid test' (oh how I liked punning that one!) for entactogens as opposed to straight psychedelics ios if the S isomer is more potent, it's mainly entactogenic in action (well that only applies to optically active phenethylamine derivatives - psychedelic phenethylamines are more active as the R isomer)
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Call me an idiot, but how do you have optical isomers of the PEAs?
 
Enantiomer-specific synthesis, if he does.
(He's not saying that he does, from what I can see - that's just a SAR observation; the way/angle the ethylamine sidechain comes off the aromatic system in a PEA, for example, alters how well the ligand key fits in the receptor lock, whether that be a monoamine reuptake transporter or a 5-HT2A receptor - F&B is just stating the rule that has proven to be accurate)
 
My point is that there is no chiral carbon in a simple PEA. Only if you insert things like cyclobutane/...ane off the ring is it possible to make a chiral PEA, in which case it not really a PEA anymore.
 
YOU ADD AN ALPHA ALKYL GROUP

I just used the term (well acronym if anyone's being picky) to distinguish amphetamines & alpha ethyl PEAs from say AET . Of course simple phenethylaminme doesn't have a chiral cantre, but how many entactogens are there that only consist of a 2 carbon side chain?

PEAs (phenethylamines) is an accepted term to cover amphetamines, alpha-ethylphenethylamines etc as well a the 2 carbob chain compounds.

After all the term tropane alkaloids is inclusive of ecognine derivatives as well as simple hydroxytropane esters.

It seems that you're just being picky and arguing over semantics
 
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^haha

Yes, f&b is right.
Amphetamines and methamphetamines are also PEAs.
They have chiral centers due to the N,alpha-methyl group.
Mescaline OTOH is a straight PEA with no chiral center.

I would draw a Venn diagram, but I am not that computer literate.
 
Yeah - amphetamine = alpha-methyl-phenethylamine. It's a neat-sounding shortening.
Still has the phenethylamine skeleton.
 
yikes, sorry, i really thought i was missing something there for a while. I'm just used to hearing them called PPAs.
*goes to shirk in corner with bucket of water to dowse flames*
 
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kidamnesiac said:
yikes, sorry, i really thought i was missing something there for a while. I'm just used to hearing them called PPAs.
*goes to shirk in corner with bucket of water to dowse flames*
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*puts a party hat on you* :D
 
Get out of the corner! Everyone has the right to an opinion and everyones opinion is equally valid. The more people who contribute, the better.
 
Don't worry, I've dropped some huge bollocks in my time.The important thing is to learn & move on (& try and forget the embarrasment in my case!)

I've had enough flanes to last a bloody long time so I'm not going to make more (nor is anyone else - not a request, but... you lnow what I mean=D)
 
hey mad scientist i think there is evidence of mmdma on the street in one of the latest microgram bulletins. I think the pills were trace amounts and were in combination with mdma, most likely a byproduct of the synthesis
 
Ok so its another purely speculative chemical idea but I can't help myself.

I know substituted 2-aminoindans are serotonin releasers. Also IndanylaminoProprane is similar. So IdanylaminoIndan (IAI) - I knows that not correct but I can't work out the correct name.
 

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5.6-trimethylene-2-aminoindan (TMAI - well that's what they'd probably abbrieviate it to - so bloody predictable! =D)

If that Nichols paper is anything to go by, it'll just be all serotonogic and no dopamine, which is what seems to disappoint a lot of people about IAP, even though IAP has reasonable activity on the dopaminergic pathways, but much much (25x) affinity for the serotonogic system, sort of unbalancing it from that seen with MDA & MDMA.

Personally I don't see why they don't try 7-methoxy-5-(2-aminopropyl)indan. It;s to MMDA what IAP is to MDA. It may have some qualities in common with MMDA. Well worth finding out eh?
 
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