Dissociatives Enhancing Ketamine Visuals?

[thepaleking]

Hey BL,

For some background, I have used K over the past year, starting with IV infusions (typically at doses of 130mg or 1.8mg/kg) then moving onto at-home rapid-dissolve tablets (at 600mg to make up for oral roa). I did around 8 infusions and a number of at-home treatements before deciding it wasn't really providing an antidepressent effect. Fast forward to today, and it's been about 5 months since I last did K and recently picked up some powder of decent quality with the intention to hole (not for theraputic purposes, of course).

One thing I remember about my IV infusions and some of my at-home sessions were the incredible visuals I would get within the K hole, sometimes seeing geometric surfaces, cascading beams of light, and other trippy, dissociative visuals. Towards the end of my at-home theraputic usage, and recently when doing a few large bumps of this new powder, while I would hole it would just be a black, jumbled mess. Visuals tended to be less clear and I'd not experience the same sense of 'going on a journey' out of my body.

I realize that this probably points to the very long tolerance that comes with ketamine usage (or I'm just dosing too low), and that some of that 'magic' may be lost for longer than I expected, but has anyone shared this experience? Is there a way to enhace the visual aspect of the hole even with simple things like the lighting of the room/eye mask?

Also, as a bonus question, I've noticed K has a bit more of a 'hangover' after effect rather than an 'afterglow' that typically consists of feeling like my nerve endings are full of TV static, a small "crash" in mood/energy and, for lack of a better word, feeling mentally retarded. Again, this might all be the result of gaining a tolerance or losing the magic to a degree, but if there are any potential remedies to these feelings (I find a small amount of cannabis helps after the comedown to ease some of the discomfort) I'd like to know your experiences!

(also please share your favorite music to listen to in the hole okay tysm goodbye)

 

[passthepills]

I don’t have much experience with ketamine but I’ve started at home treatments and have done a little recreationally a few times in the past few years. Today I found out from my NP (who’s supervising this with me) that there are two different types of ketamine, even in prescriptions. I was asking about the intra nasal spray instead of SL and she said the only issue is that that one often doesn’t have the chemical with better affects. I wish I could remember the letters she used to identify the better one vs the less effective one, but I don’t. I see her again Friday though and could ask.

So it could just be that you had the more effective ketamine when you had visuals and not when it was just dark.

 

[Viraldrome]

when i took it on 2-cb i found it was easier to remember all the cool shit i saw i dont know if i would say it enhanced it though

 

[Shinji Ikari]

2cb

And favourite hole anthem

 

[Allylbenzene]

I realize that this probably points to the very long tolerance that comes with ketamine usage (or I'm just dosing too low), and that some of that 'magic' may be lost for longer than I expected,

Imo the likely explanation is the K used in the treatments was pure (S)-ketamine and the powder you got was a mix of (R) and (S) isomers. The S is the disassociative type (for vets, prescription) but the R is primarily a dopamine reuptake inhibitor like cocaine...

I've noticed K has a bit more of a 'hangover' after effect rather than an 'afterglow' that typically consists of feeling like my nerve endings are full of TV static, a small "crash" in mood/energy and, for lack of a better word, feeling mentally retarded. Again, this might all be the result of gaining a tolerance or losing the magic to a degree, but if there are any potential remedies to these feelings (I find a small amount of cannabis helps after the comedown to ease some of the discomfort)

I haven't used K in ages but there are some things which will help by restoring/repairing fundamental areas, specifically the body's core metabolic system which everything else relies on.

• low-dose niacinamide (vitamin B3)
• low-dose thiamine (vitamin B1)
• low-dose pregnenolone (OTC)
• agmatine - similar theraputic effects as K with added psychedelia
• theanine - blocks the stress response

You'll find that most of those will have an antidepressent effect too.

 

[BorbOrB]

Ketamine, racemic or esketamine, always have visuals that are indescribable and certainly not "geometric" or tangible, thats what I'd use to describe dmt. They use mostly esketamine in the medical field for humans. With MXE I got visions of characters and the universe and tangible things along with intangible abstract messes.

 

[BorbOrB]

Arketamine by itself isn't that great but I bet racemic (arketamine with esketamine) is more what you want as together they hit more receptors and will have more complex visuals. Try sourcing veterinary ketamine vials which are racemic and that'll answer it for you

 

[Innerpeace]

I only done r and that was enough for me . I've done fxe as well

At higher doses visuals are there and bright colors and sounds were too intense for me so I closed my eyes

Like psychedelic s , like mushrooms, and lsd, it's best to close your eyes, focus in your breathing, optional to listen to music you enjoy, you can sort things out much better with closed eyes than open eyes

Opening eyes every now and then can be cool but when I'm using it more for therapeutic reasons, from experience,closing my eyes, seems to help me organize thoughts, stay more focused on improving my self and my soul

 

[Khacorrat]

I share your view Innerpeace, I recently do S-isomer while watching Dune part two. For those who know the films, you know there is a lot of music and some black&white scenes. At a point, I thought I couldn't see colors anymore and that all the world became black&white. Also I wasn't aware of the up&down.

Pretty hectic, at a moment I told myself "Ok, now I fucked it all. I will stay like this" but without any stress. It was a pretty wild experience for me, but an interesting one

 

[emkee_reinvented]

Hey BL,

For some background, I have used K over the past year, starting with IV infusions (typically at doses of 130mg or 1.8mg/kg) then moving onto at-home rapid-dissolve tablets (at 600mg to make up for oral roa).

Aren t medical pro s concerned about bladder problems taking doses that high ?
600 mg in how many day s, not a day right that seem s dangerous high imo.

For getting a good grip of a K-hole. MDMA synergism with more then well.
On the comedown i could about lucid hole on half the amount needed normally.
About lucid a thin line to surf bit to much and you get lost in the K-hole.

And when daily dosing not a viabel option. But i prefer a good trip once a month.
Then daily dosing that amount of Ketamine. my only exp with racemic.

 

[Innerpeace]

I share your view Innerpeace, I recently do S-isomer while watching Dune part two. For those who know the films, you know there is a lot of music and some black&white scenes. At a point, I thought I couldn't see colors anymore and that all the world became black&white. Also I wasn't aware of the up&down.

Pretty hectic, at a moment I told myself "Ok, now I fucked it all. I will stay like this" but without any stress. It was a pretty wild experience for me, but an interesting one

I understand what you mean. Last movie I watched was karate kid to new one in netflix. It was almost, not quite I was sucked into the movie. This was 50 mgs r ket so not intense really, much better alternative to alcohol

Another one was gods of Egypt a year before the karate kid, in 2024 , the scene morphed and a guy got all close to another guy , one was quite bigger and it was a lil weird. Not sure if it was in the real movie or it was the ketamine , or both . That was 20 mgs fxe, and 20 mgs r ket and that was so much stronger than a standard dose for me at the time which was like 70-80 mgs fxe. Was first time expirementing with ketamine

Nice novel stuff and can have it's place, but it wears off and I prefer sorting things out internally more when I feel it's best to focus inward for my health

 

[Mjäll]

Speaking of R-ket, i've also tried what was reported to be R-ket but at the same time i'm suspicious of its existence on the market.

I would have guessed even S-ket would be largely non-existent on the black market, and would be quite expensive if derived from the pharmacological market. But when i came across it, it was dirt cheap just like normal racemic ket.

I could tell the difference between supposed R-ket and racemic, but the supposed S-ket was indistinguishable from racemic to me. Granted, i was already on racemic ket when trying it.

 

[Allylbenzene]

This came up on another thread - ketamine appears to have estrogenic effects. I used to use it but nowadays I wouldn't consider it suitable...

One way that estradiol impacts microglia is via the estrogen receptor (ER) α.
...
Evidence that ketamine binds to ERα, was provided by Ho et al. (232). Radioligand binding assays, coupled with surface plasmon resonance, demonstrated that estradiol, ketamine, and 2R-6R/2S-6S HNK bind to ERα receptors in cultured astrocytes.
— https://doi.org/10.3389/fpsyt.2021.797577

 

[thepaleking]

Aren t medical pro s concerned about bladder problems taking doses that high ?
600 mg in how many day s, not a day right that seem s dangerous high imo.

For getting a good grip of a K-hole. MDMA synergism with more then well.
On the comedown i could about lucid hole on half the amount needed normally.
About lucid a thin line to surf bit to much and you get lost in the K-hole.

And when daily dosing not a viabel option. But i prefer a good trip once a month.
Then daily dosing that amount of Ketamine. my only exp with racemic.

The regiment my psych had me on was 3x/week for 2 weeks, with a week break to prevent bladder problems. I'm a bit skeptical that this would actually work to prevent those problems, and one of the reasons I stopped taking K that way was because it really felt like the treatment was pretty hard on the body.

 

[emkee_reinvented]

The regiment my psych had me on was 3x/week for 2 weeks, with a week break to prevent bladder problems. I'm a bit skeptical that this would actually work to prevent those problems, and one of the reasons I stopped taking K that way was because it really felt like the treatment was pretty hard on the body.

Sound s reasonable could have been oral 600 mg multiple times a day ?
Not expert K always hard to find back in the day. Loved Methoxetamine.
Very good for mood and long duration. Totally different btw.
Ketamine was unique in effect s and has that after glow. A positive one.


Ketamine oral a roa that i never considered, How is it ?

 

[Skorpio]

Thc always “colors in” dissociatives for me when I’ve done them (I do agree with thc baseline). Could be a first approach if that’s something you are generally ok with.

Also cool username, The Pale King is such an underrated DFW book.

 

[placebonaut]

I could tell the difference between supposed R-ket and racemic, but the supposed S-ket was indistinguishable from racemic to me. Granted, i was already on racemic ket when trying it.

The 3 are night and day different for me, S-ket holes much easier with intense geometric visuals, I fine it impossible to hole on R-ket even at double the amount of racemic I'd need.

S-ket and R-ket are rarer but available

 

[Esperighanto]

If you're working with clandestine ketamine, ignore all of this talk of isomerism. I have yet to see a single confirmed case of isomerically purified ketamine existing outside of clinical contexts, but I'm waiting to be disproven in that regard.

Ketamine visuals were best for me when I had a low tolerance, dosed high (but often just before holing out), and when I mixed the ketamine with other visually rich substances. Even an 8mg oral dose of 2C-B, my daily bupropion/caffeine, some amphetamine or methamphetamine, other arylcyclohexylamines, DXM, allylescaline, LSD, DOM, etc. have all worked well for me in this regard.

 

[xdrc]

If you're working with clandestine ketamine, ignore all of this talk of isomerism. I have yet to see a single confirmed case of isomerically purified ketamine existing outside of clinical contexts, but I'm waiting to be disproven in that regard.

Kykeon Analytics even has a challenge:

We are offering a free analysis to anyone who sends in a sample which turns out to be either pure S‑ketamine or pure R‑ketamine! To participate, simply send in your sample for testing with the “enantiomer” analysis. We will then test it and if the sample is at least 90% S‑ketamine or 90% R‑ketamine, we will contact you and send you a free analysis coupon for your next sample.

As part of a formal scientific study to assess ketamine from unregulated sources, your submission not only gives you a chance to win a free analysis but also contributes to research that will benefit public health and improve understanding of the supply.

It is relatively simple to build a makeshift polarimeter however. You can test it with chiral substances like saccharose (household sugar), glucose, etc. You just need a polarising filter or spare 3D glasses with such filters. See:

https://pubs.acs.org/doi/abs/10.1021/acs.jchemed.7b00767 (access via Sci-Hub or Annas-Archive, technique using phone and 3D glasses -> should be enough to see if your ketamine has a chance of being chiral)
https://pubs.acs.org/doi/10.1021/acs.jchemed.9b01083 (Free Access, requires 3D printer with black filament, an LED and polarising filter, more accurate - you can probably build this thing without a 3D printer too)

I built that last thing. For the scale you need to briefly install CoralDraw (there is a free test license) to print at the accurate dimensions. Wanted to use it to test d-3-FA but ran out of it before mustering up the motivation (quite ironic, huh?) of measuring it. Schrödinger's dexamphetamine.

 

[placebonaut]

It is relatively simple to build a makeshift polarimeter however. You can test it with chiral substances like saccharose (household sugar), glucose, etc. You just need a polarising filter or spare 3D glasses with such filters. See:

https://pubs.acs.org/doi/abs/10.1021/acs.jchemed.7b00767 (access via Sci-Hub or Annas-Archive, technique using phone and 3D glasses -> should be enough to see if your ketamine has a chance of being chiral)
https://pubs.acs.org/doi/10.1021/acs.jchemed.9b01083 (Free Access, requires 3D printer with black filament, an LED and polarising filter, more accurate - you can probably build this thing without a 3D printer too)

have read about this method of testing before, seems straight forward and the science makes sense