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Endorphins

IAmJacksUserName said:
Out of curiosity, when can you feel endorphins?
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Whatever it is that makes you feel good, its usually after exercise. If I work out hard enough or long enough sometimes I get adrenaline (or whatever, I get stronger, more energizied, and more aggresive) during the workout. Normally, I will stop at this point as I have hurt myself several times with the thought, "I can do more and with more weight!" and than ended up not walking right for days, never mind lifting.
 
BilZ0r.. It is no wonder that people who know what the fuck they are talking about don't post at places like this... I appplaud your effort. lol

:)

I work out almost every day... I get out... and feel: Relaxed, Euphorpic, slightly stimulated.. slightly tripped out... clear,... the list goes on.

This is "feeling" is FAR more complicated (IMO) than a single trigger chem or group.
 
^ Yeah, and it definately doesn't feel like any opioid I've ever taken.
 
BilZ0r said:
^ Yeah, and it definately doesn't feel like any opioid I've ever taken.
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Really?

I find the euphoria is nearly identical to that which I experience on opioids. Warm, clean, joyus.

Post lifting feels like a cross between opioid euphoria and cocaine ego boost, minus the bad effects of either. But I can clearly tell when I 'comedown' from a workout, usually 2-3 hours post workout.
 
Anybody know much about Endomorphin-1?

Tyr-Pro-Trp-Phe-NH2

I means its only 5 a.a residues long so its not exactly breathtaking stuff. Apparently it is short acting but hey hoe it looks like it might be worth persuing.
 
^ Yeah, I looked about that one, because it looks BBB permiable.
 
IAmJacksUserName said:
Out of curiosity, when can you feel endorphins?
Click to expand...

I feel it at its strongest after an hour long squash game....thats a very intensive aerobic workout at 500 calories burned per half hour . Whew.
It's sort of like im sweating, breathing hard and these sparks are coming off the top of my head lol. I love it.
 
I should stop bothering, the idea the exercise causes endorphin release is to far burned into the western psyche. *sigh*
 
^no, not at all :) these endorphins facinate me, but i don't think they are solely what makes you feel good after a workout - it may not have anything to do with them at all, lets keep an open mind guys, since we haven't got many solid studies to go by i'd say, in my personal experience, the feel good bit after a workout is a combo of lots of things.

I would def be interested in seeing some studies done with synthesised endorphins.
 
^^ true true true..bilz0r i just used the catch all "endorphin" to describe what I feel after a good workout...although I believe you when you say it may not be that at all =D
 
On another forum in a registered-users only subforum, there were people who claimed to have ordered beta-endorphin and dermorphin and claimed they were active IVed. However they were just random people on the internet... I'll try to find a link if I remember later...
 
i found some dermorphin online. it starts at 365.00$ for 25ug!!!!!!!!!!!!!!!!!!!!!!
 
What happens post-orgasm then? Those are endogenous opiates in your brain, are they not? For me the feeling right after sex is almost exactly the same as that of dosing on some oxy.
 
^ No one knows what happens post orgasim. I think it feels much nicer than opiates.
 
I would have to disagree with you. Post orgasm doesnt come anywhere even close to a good hit for me. I forget I just had sex only a few minutes later. Whereas the bliss from O lasts, and lasts, and lasts.
 
Hey, wow, I just noticed this..

You only have 4 a.a.s listed, not 5. Either way...

SWIM (yes we all know who swim is so no comments needed) could work up mgs of this recombinantly produced by E. coli very very very easily.

I'm going to speculate that it would get chewed up by trypsin/chymotrypsin if taken orally. There's no way that SWIM would systemically admin this from recombinant E. coli either (mmm LPS in the blood, toxic shock and death).

Any thoughts on how else this could be bioassayed?

Smyth said:
Anybody know much about Endomorphin-1?

Tyr-Pro-Trp-Phe-NH2

I means its only 5 a.a residues long so its not exactly breathtaking stuff. Apparently it is short acting but hey hoe it looks like it might be worth persuing.
Click to expand...
 
BilZ0r said:
^ No one knows what happens post orgasim. I think it feels much nicer than opiates.
Click to expand...

It has some of the qualities of opioid drugs, but it's a lot more complicated in that there's an element that's heavy on the empathy (MDMA-like), those 'God I love you' moments and additionally a cannabinoid like feeling where your thoughts are prone to wandering - some might say, but that's opioid like - but in a manner ajin to cannabis intoxication, in that there are conceptual links that might not seem obvious to the normal, calm & rational mind.

The actual moment of orgasm even has certain aspects that are reminiscent of ketamine - like the loss of body image and reduction/elimination of just about all sensory input; for those few seconds during ejaculation, you're completely inside your own head (sorry ladies, I wasn't being sexist going on about ejaculation, it's just that I was talking from personal experience and I've never had a female orgasm!).

All in all, orgasm is a lot more complex in terms of what's experienced than what you get from an opioid drug
 
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