Based solely on personal experience I would have to say it can be pretty damaging. The interior of my nose constantly feels like the barrel of a .45 caliber pistol...hot, dry, kind or gored out (not wet and smushy like the way snorting cocaine makes it feel). Of course I have been habitually snorting methamphetamine hcl for about 1 1/2 years (with the occasional month break or switch to smoking). Sorry this is not scientifically based, but I am sure someone will reply with actual facts.
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"All great things must first wear a terrifying and monstrous mask in order to inscribe themselves on the face of humanity"
-Nietzsche