Ecstasy help

[Stevenmac]

I just went to mysterlyand a 3 day festival and popped Molly all 3 days as well as the day before but also popped about a week before hand, the first day of the festival wen dropped I would peak hard for about 20-45 minutes and then sober up very quickly and would continue second day I had to buy Molly off a stranger and that roll was mo what I'm used to as far as affects it was just a small dose, the 3rd day I took the Same stuff I had the first day and took a very large dose and had a very subtle roll, also all 3 days I ate very little but ate the most on the second day, can someone help me with this problem, I've never experienced this before

 

[Jabberwocky]

I just went to mysterlyand a 3 day festival and popped Molly all 3 days as well as the day before but also popped about a week before hand, the first day of the festival wen dropped I would peak hard for about 20-45 minutes and then sober up very quickly and would continue second day I had to buy Molly off a stranger and that roll was mo what I'm used to as far as affects it was just a small dose, the 3rd day I took the Same stuff I had the first day and took a very large dose and had a very subtle roll, also all 3 days I ate very little but ate the most on the second day, can someone help me with this problem, I've never experienced this before

Tolerance

or

not MDMA

or

not much dose

 

[augustaB]

Assuming it was mdma you scored, your serotonin will have been depleted by rolling the week before. So the first day you only had a little roll. The next day you had absolutely no serotonin at all left and the third day you less than none.
No wonder then that you didn't roll. Sorry mdma doesn't work like most other drugs. You have to have serotonin to release.

 

[Clocktower]

Too much drugs. Use less and your problem will be solved.

 

[giovanni557]

My advice is to quit this drug for good and stay clean I did Molly so I'm telling you from my experience do a research first so that you later do not regret take care.

 

[Jabberwocky]

Assuming it was mdma you scored, your serotonin will have been depleted by rolling the week before. So the first day you only had a little roll. The next day you had absolutely no serotonin at all left and the third day you less than none.
No wonder then that you didn't roll. Sorry mdma doesn't work like most other drugs. You have to have serotonin to release.

Stop with the myth -- serotonin is constantly being synthesized -- tryptophan hydroxylase was only inhibited in rats by 50% after an injection of 10 mg/kg (about a 15-20 mg/kg oral dose)

If he took some MDA it would work just fine and it works due to serotonin release.

MDMA tolerance is NOT caused by serotonin depletion, it is caused by transient downregulation of the receptor complex and loss of binding affinity to MDMA at the receptor and SERT and the synaptic vesicle VMAT and TAAR1 -- Shulgin reported that after complete tolerance from a week of daily dosing tolerance resolves in a week of abstinence

Release is blunted (less serotonin released -- not because of depletion) and sensitivity of the receptor is lowered.