Originally posted by synchrojet:
In any event, I think schizophrenia is still so misunderstood that there can be no reliable conclusions drawn about the impact of these drugs on the schizophrenic mind.
You are wrong. These drugs have been shown to exacerbate psychotic symptoms or trigger acute psychotic episodes in schizophrenics. In addition, the metabolic activity produced in the brain by psychedelics is strikingly similar to that observed in acutely psychotic schizophrenic patients. The "atypical" antipsychotics are highly efficacious at both treating neuroleptic-resistant schizophrenics and antagonizing the effects of psychedelics, indicating that the two share common mechanisms of action. Based on this evidence, it is very reasonable to conclude that these drugs may exacerbate or trigger psychosis in schizophrenics.
Originally posted by MerryGlowstick:
E brings out the schitzo in people, medically, being on e is the same as having schitzo, schitzo have stiff jaws and everything!
This is wrong. Being on E is nowhere near the same as having schizophrenia. Being on a 5-HT2A agonist hallucinogen such as LSD, psilocybin, or DOI does produce neurological and behavioral symptoms that are similar, but not identical, to the acute, positive psychoses that often typify the initial stages of schizophrenia. Now, MDMA is a weak 5-HT2A agonist, but its activity at other receptors does not make it as accurate of a model for acute schizophreniform psychosis.
On-Lucid said:Intriguing. So basically, what you are saying in this case is that an acute psychosis (of the positive form) is what follows the negative type forms of schizophrenia manifested by depleted serotonin levels cuased by mdma or stress or something else of a negative nature?[/QB]
(such as speed psychosis where positive form schizophrenia is iniated by an overwhelming increase in adrenaline coupled with a decline in dopamine levels)
If so, would it be fare to say, when compared to other types of drug induced psychosis, that positive symptom psychosis as a result of mdma usage is the most unlikely form in which drug induced psychosis is likely to occur?