Opioids Dyphenhydramine works as good as promethazine for potentiating opiates ?

[AngelOfDeath415]

Can it replace promethazine, do they work similar?

 

[spanish_opioiduser]

Dont know what you mean exactly, dph with opioids is a horrible combination that can increase exponentially the chances of an accidental overdose.
In low doses it could have some anti-allergy benefits like reducing that annoying itchiness all over the skin and runny nose, it could also potentiate the nodding but definitely that's a risk anyone should consider

 

[AngelOfDeath415]

Dont know what you mean exactly, dph with opioids is a horrible combination that can increase exponentially the chances of an accidental overdose.
In low doses it could have some anti-allergy benefits like reducing that annoying itchiness all over the skin and runny nose, it could also potentiate the nodding but definitely that's a risk anyone should consider

Sure, I'm gonna die from mixing an opioid/antihistaminic (most flu medicines Already use this combination) while some here shoot heroin/fentanyl in their dicks and seem encouraged to do so. My question was if it's a good potentiator for codeine/morphine or if it will slow down the opioid metabolism since dypenhydramine uses same enzyme as codeine

 

[AngelOfDeath415]

For example glutethimide is a powerful potentiator for codeine, makes it almost as good as pure morphine. Can't get that tho soo does dypenhydramine or promethazine work similar

 

[Jnowhere]

Dont know what you mean exactly, dph with opioids is a horrible combination that can increase exponentially the chances of an accidental overdose.
In low doses it could have some anti-allergy benefits like reducing that annoying itchiness all over the skin and runny nose, it could also potentiate the nodding but definitely that's a risk anyone should consider

Yo, I have been on Oxy for over 8 years and I use benadryl (I have allergies and never get opiod itch) How much is he planning on taking? 50-75mg has never been an issue.

 

[Gaz_hmmmm]

It can be as good when it comes to the sedation side of things and promethazine is good with codeine cause it increases it's metabolism in to morphine.

However if you're using promethazine with methadone or say oxycodone, then it will speed up metabolism and not in a good way.
It may increase some of the oxycodone to oxymorphone metabolism but it will also speed up it's metabolism, potentially making the high last a shorter time.

I'd only use promethazine with codeine, morphine or H but not everyday cause one of promethazine's metabolites works like the old 1950's first generation anti-psychotics/neuroleptics.
Definitely not something you wanna be using daily.

 

[AngelOfDeath415]

Yo, I have been on Oxy for over 8 years and I use benadryl (I have allergies and never get opiod itch) How much is he planning on taking? 50-75mg has never been an issue.

100-150mg . I won't go too crazy with antihistaminics considering they make you hallucinate at higher dose

 

[Gaz_hmmmm]

100-150mg . I won't go too crazy with antihistaminics considering they make you hallucinate at higher dose

What antihistamine is Benedryl that you're referring to?

Cause I know in the US it's a different drug to the UK brand of Benedryl and I wouldn't wanna be taking more than 100mg of diphenyhydramine cause of the risk of hallucinations (DELERIUM!!!) and problems focusing with your eye's that can last two weeks!

 

[AngelOfDeath415]

It can be as good when it comes to the sedation side of things and promethazine is good with codeine cause it increases it's metabolism in to morphine.

However if you're using promethazine with methadone or say oxycodone, then it will speed up metabolism and not in a good way.
It may increase some of the oxycodone to oxymorphone metabolism but it will also speed up it's metabolism, potentially making the high last a shorter time.

I'd only use promethazine with codeine, morphine or H but not everyday cause one of promethazine's metabolites works like the old 1950's first generation anti-psychotics/neuroleptics.
Definitely not something you wanna be using daily.

That would be dypenhydramine , I'm not in US.

 

[Jnowhere]

I am not trying to get high. I am in pain. OK with all the other meds I take; I get comfortably numb.lol ( relaxed and now physical and emotional pain and anxiety are gone with my legally prescibed cocktail of prescription drugs). Chasing a high with oxy is just going to ruin your tolerance fast and possibly your bank account if you are middle class or below, especially if you have family, a job that you need to to survive.

You will get high for awhile with rapidly increasing doses till you find your self broke and probably not always able to get more. I take, the no Tylenol version. Not so funny thing; when opiates were easy to get in America( good ones) people could easily abuse Vicodin or Norcos or Percocet or better ones like Oxycontin( the old and very good ones, especially the really strong ones, they suck now and IR is the best with no Tylenol), and others ect..

However, people who didn't OD and were taking large amounts of most of the more readily available ones, Vicodin, Norcos Percocet, ect... Died not from the Hydrocodone or Oxycodone Ir with or without Tylenol( Oxy which is so much better for pain, incredible mood lifts, and from what I have heard,lol, getting high.) the Tylenol, acetaminophen, or paracetamol, or whatever you want to call it; that liver rotting shit. Liver failure and I know from experience; that if screwed up your liver in America; in many states you have to piss clean for 6 months, before even getting on the organ donor list. then possibly years and you die or if lousy or no insurance a massive medical bill. I was Medicaid and could have gotten one for free.

There are other way to potentiate opiates especially Oxy. Also.

 

[Jnowhere]

You need alot more to hallucinate and tolerance skyrockets and the effects are not good, apparently. 100-150mg's shouldn't cause hallucinations. Check out if using larger amounts; can be dangerous to your organs over time. Getting high on extremely large amounts sucks, apparently from what I understand.lol

 

[Them Witches]

Currently, 40% of users are potentiating their opiates with enhancers. Commonly used OTC enhancers include grapefruit juice, cimetidine, codeine, diphenhydramine, quinine,vitamin supplements. most of these are Rx -- gabapentin, promethazine, Hydroxyzine PAM< must this model, clonazepam, Inapsine (droperidol), Clonidine, Zanaflex,
Chlorpheniramine, Cyclizine, Doxylamine succinate, phenothiazine, MAO, Inhibitors, some tricyclic antidepressants, alcohol, benzodiazepines.
Dimethylsulfoxide, Clomipramine, Proglumide, Chlorpheniramibe Maleatem(CPM), ofolanzapine, Seroquel, AA's, carbamazepine, phenytoin,
Clozapine, olanzapine, Baclofen, meprobamate, carisoprodol, chlorzoxazone, methocarbamol, tizanidine, metaxalone, orphenadrine, and cyclobenzaprine,

Hard to except but they do at a recorded level :
luconazole (FLC), itraconazole, voriconazole, ketoconazole, terbinafine, tolnaftate, caspofungin, micafungin, anidulafungin, nystatin, amphotericin, methylphenidate,
d-amphetamine, atazanavir (ATV), raltegravir, antiretroviral, tropicamide,magnesium sulfate, Valerian Root extract, some steroids help the opioid cross the blood brain barrier,
better.... taking Tums before the dose PO helps it stay in the liver longer for more absorption with the related/needed enzymes.

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Using Over-the-Counter and Other Prescription Medications to Potentiate Opiates in the USA: Literature Review. Medical and Public Health Aspects of OTC Medication Misuse

Opiates are generally indicated for the treatment of various pain syndromes; however, if alternate treatments have been exhausted and a physician elects to prescribe opioids, then both the physician and patient should be aware of the risks associated with use.

www.heraldopenaccess.us

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[Them Witches]

Oxy which is so much better for pain, incredible mood lifts,

yes indeed

 

[4DQSAR]

For example glutethimide is a powerful potentiator for codeine, makes it almost as good as pure morphine. Can't get that tho soo does dypenhydramine or promethazine work similar

No.

 

[evo4ever]

Promethazine is much better than Diphenhydramine for potentiating opioids. The optimum dose is 100mg, don't take anymore than that.

 

[Tranced]

Can it replace promethazine, do they work similar?

Yes, diphenhydramine, commonly found in Benadryl, has been linked to an increased risk of dementia, particularly with long-term use in older adults. Studies suggest that prolonged use of anticholinergic medications like diphenhydramine may negatively impact cognitive function and raise the risk of developing neurodegenerative diseases.

From chatgpt & just so you're aware.