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BDD Moderators: Keif’ Richards
DXM the day after suboxone
- Thread starter DroneLore
- Start date
Psychedelic Jay
Bluelighter
No. DXM has virtually no affinity for m-opiate receptors at any dose humans could possibly use.
mygreenbic
Bluelighter
I think i may disagree with this answer. I believe dxm had activity at the kappa opiod site <in addition to ndma antagonism of course > and I think suboxone is one of, if not, the most potent kappa opiod antagonists out there. I've done dxm for years. I used to love to do it on methadone, and doing heroin at the tail end of a good dxm trip night possibly be the best feeling ever... but taking it with suboxone it definitely is different. I can't put my finger on what it is, but I do actually think it loses some of the psychedelic effect. Note this could also be due to enzyme interaction.
To the poster above me, no offense but when looking at stuff like this you have to consider everything not just receptors but also activity of enzymes especially with dxm as it effects the dxm to dxo ratio which is basically yep different drugs in the body.
To the poster above me, no offense but when looking at stuff like this you have to consider everything not just receptors but also activity of enzymes especially with dxm as it effects the dxm to dxo ratio which is basically yep different drugs in the body.
adder
Bluelighter
- Joined
- Mar 28, 2006
- Messages
- 2,851
I took DXM on top of Suboxone for a week or so and I didn't notice any lack of depth before I got tolerant. However, depressant effects of DXM and buprenorphine create a synergistic effect. My heart rate and my breathing slowed down after taking DXM like they never did before on DXM or Suboxone alone, during the peak of DXM/DXO effects my heart rate was ~60 BPM and my pulse was very weak, so be very careful combining opioids with dissociatives.
That's interesting what you say about DXM being a kappa agonist, mygreenbic, but I think it's not a fact but just a supposition originally made by Hustveit et al. Or do you have some other source?
Article abstract
I searched for a proof but all I could find were articles either giving no source or sourcing Hustveit et al. IMO There's definitely something that NMDA antagonist dissociatives, kappa agonists like Salvinorin A, and also 5-HT2A psychedelics (some probably more than other ones) have in common, it could be some indirect effect or an action at a so far unknown site (of already known receptors perhaps), but I don't think there's any proof for that at the moment. I wouldn't be surprised if it was a trigger-like action rather than a continuous effect.
That's interesting what you say about DXM being a kappa agonist, mygreenbic, but I think it's not a fact but just a supposition originally made by Hustveit et al. Or do you have some other source?
Article abstract
I searched for a proof but all I could find were articles either giving no source or sourcing Hustveit et al. IMO There's definitely something that NMDA antagonist dissociatives, kappa agonists like Salvinorin A, and also 5-HT2A psychedelics (some probably more than other ones) have in common, it could be some indirect effect or an action at a so far unknown site (of already known receptors perhaps), but I don't think there's any proof for that at the moment. I wouldn't be surprised if it was a trigger-like action rather than a continuous effect.
mygreenbic
Bluelighter
Adder good post on your part. I should have quoted the articles that I read that in but here is an interesting bunch of information on dxm potentiality effects of mu agonists but not certain kappa agonists.. I will let the articles do the talking because I'm on adderall right now and don't want to over type http://www.ncbi.nlm.nih.gov/m/pubmed/15655510/