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Opioids DXM dosage to control tolerance? What RATIO of DXM to your dosage? 1:1 ratio? Or?

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CaliBoy90

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Mar 2, 2014
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Just like the question says. I always hear people saying that a LOW dose anywhere from 15mg to 90mg of DXM 30 mins to 1 hour before taking Oxycodone is best to control tolerance... Although I've never read anyone say what's the recommended RATIO? What if you are taking low doses? Example: If you only are taking 10MG of Oxycodone, how much DXM beforehand would be the proper dosage then? 1:1 ratio? That seems kinda high ratio. It seems like 50% of the Oxycodone dosage would equal the proper DXM dosage to help tolerance, so in this case 5mg of DXM before the 10mg of Oxycodone would help tolerance. Or? Anyone know? (also read below, I asked if even 5mg of dxm would be enough to even "start causing nmda action or not")

Also: if you are taking 10MG of Oxycodone every 4 hours (so 6 times daily, a total of 60mg daily), should you take a low-dosage like 5mg of DXM before each dosage? This would mean taking DXM 6 times per day. Seems like perhaps too much. Although it's low doses..
So would taking the extended release DXM (dxm polistirex or whatever it's called) be a better choice? ALTHOUGH IF YOU TAKE THE EXTENED RELEASE, then how would you adjust the dosage??? What would the proper ratio be now, since it's extended release? Would taking 30mg of extended release DXM once in the morning be enough to control tolerance for the entire day if taking only 10MG of oxycodone 6 times daily?

Lastly: at what dosage does DXM have it's NMDA agonist properties? Since this is the whole reason it's believed to control tolerance, then knowing at what dosages it starts to have "NMDA Action" would be good to know. If at small dosages of 5mg DXM doesn't produce any "NMDA action" then it would be useless for tolerance, right? So is there any minimum dosage required of DXM to take for it to start having NMDA action? Or does ANY dosage of DXM work for causing NMDA action (therefore helping tolerance), even if only 5mg of dxm??
 
You don't take DXM in a "ratio" to your opioid, it's just supposed to be enough of a dose to tickle your NMDA receptors, which for most people (depending on weight and personal genetics) is usually around 30-60mg, but can be increased up to the point where you start noticing wierd psychedelic side effects.

The rule of thumb for DXM polistirex is it's "half as strong for twice as long" as DXM HBr, so taking 30mg polisiteriex is roughly the same as two 15mg doses spaced 4-6 hours apart.
 
sekio said:
You don't take DXM in a "ratio" to your opioid, it's just supposed to be enough of a dose to tickle your NMDA receptors, which for most people (depending on weight and personal genetics) is usually around 30-60mg, but can be increased up to the point where you start noticing wierd psychedelic side effects.

The rule of thumb for DXM polistirex is it's "half as strong for twice as long" as DXM HBr, so taking 30mg polisiteriex is roughly the same as two 15mg doses spaced 4-6 hours apart.
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Thank you. I wasn't sure at what dosage DXM starts to "ticke your NMDA receptors". I only thought it was possibly a RATIO only because in some Morphine forumals they had DXM in it to help reduce tolerance, but it was at a 1:1 ratio for this Morphine formula they made. But if ratio doesn't matter, my question is do you mean 30 to 60mg taken all at ONCE before the Oxycodone, or 30 to 60mg for the entire day in order to get NMDA action going?
Why I ask is because I've been taking only around 15mg of DXM before my 10MG Oxycodone dosage (I have extremely fast metabolism and very low body weight), but I could feel the DXM kicking in even at 15mg doses so I assumed it was working... So does this mean the entire time the 15mg of DXM wasn't even strong enough to produce any NMDA effects and I basically wasted my time? I actually felt the 15mg of DXM kicking in, even at just 15mg, so I assumed if I could feel it giving me a slight mood boost and kicking in that it would be it having some NMDA action. I don't know anymore now though. I always felt like taking 30mg of DXM before a simple low dose of 10mg of Oxycodone would be "too much" since that's 3X more DXM than Oxycodone, but if it takes at least 30mg of DXM to start to effect NMDA action then I suppose that answers that question I wondered.

As for the DXM polistirex, since it's half as strong but last most of the day, does this mean if I take 30mg of DXM polisiteriex before my dose it would be too low to get any action going at NMDA receptors since it's only releasing about 15mg at once? Does this mean instead you would have to take at least 60mg of DXM polistirex 30 mins to 1 hour before your dose for it to even work on the NMDA receptors? 60mg of the polistirex should release 30mg right away, then 30mg 4-6 hours later. So 60mg of the polistirex taken beforehand should help tolerance/cause some NMDA activity, right? That kinda sucks, because a simple 15mg of DXM already effects me pretty strong. I can't even imagine taking 60mg at once... But if it helps tolerance, then I guess it's worth a try and maybe the polistirex won't kick in too hard.
 
my question is do you mean 30 to 60mg taken all at ONCE before the Oxycodone, or 30 to 60mg for the entire day in order to get NMDA action going?
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It works best if you take it probably 1-2 hours before your oxycodone dose, limiting yourself to about 4 or 5 doses every day, one every 4-6 hours. This is so some of the DXM gets converted into DXO - the more potent NMDA agonist. Also, DXM is not always well-absorbed in everyone, so it can take up to an hour to make it into your blood.

I always felt like taking 30mg of DXM before a simple low dose of 10mg of Oxycodone would be "too much" since that's 3X more DXM than Oxycodone, but if it takes at least 30mg of DXM to start to effect NMDA action then I suppose that answers that question I wondered.
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It varies for everyone, especially among people of various weights and metabolism speeds. It is better to judge the drug's effects by observing what happens, rather than consulting a dosage chart.

So does this mean the entire time the 15mg of DXM wasn't even strong enough to produce any NMDA effects and I basically wasted my time?
Click to expand...

If you can feel 15mg DXM, then it's very likely working. Like you said, you are a fast metaboliser. Just because you're not in the recommended dose range does not mean you have to increase your dose.
 
I meant that 30mg of DXM polistirex is equivalent to taking 15mg of DXM HBr, than 15mg DXM HBr more a while later. It's polymer bound time released DXM.

DXM for controlling tolerance is because it is a NMDA antagonist and inhibits some processes that cause your neurons to adapt to drugs, not because it alters absorption rate or anything like that.
 
Can one become tolerant to therapeutic doses of DXM? All there any direct health consequences from it other than that?
 
If one takes less DXM that needed, will it still provide some tolerance protection? Let say, one is taking 10-15mg of DXM HbR one time, contrary to 30-60 that is recommended.

And, if one is taking YaBa (meth + some kind of morphine) that has a duration of effects for about 12 hours, but takes only one 15mg DXM one hour prior to trip, will it offer some protection? Or one would need to dose two times of 30mg?
 
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