Yo. So started taking SAM-e (s-Adenosyl Methionine) about eight days ago to help with mild depression, and it started working wonderfully over the last few days. I've been feeling a lot better, a lot perkier, and a lot more like my old self. Tonight, for some stupid reason, and on a whim, I decided to take 135mg DXM to get a mild robo experience. I haven't done that in years, so I don't know why I decided to do it now. Anyway, I took the 135mg DXM and started feeling good. After I peaked, though, I was in my kitchen, and had what I assume felt like a mild panic attack (I've never had a panic attack before). It's really hard to describe what that felt like, but if you've had a panic attack, I think you'll know what I'm talking about. I was feeling hot, among many other things, so I quickly exited the kitchen and went outside to cool off in the night air, and drink some water. I sat outside and after a few minutes, my heart rate went down, and the panic started to subside. As soon as I felt able, I came inside and looked up SAM-e and DXM interactions to discover that this is listed as a moderate risk interaction, with the potential to lead to Serotonin Syndrome. I didn't know too much about Serotonin Syndrome, so I looked it up, and I seem to be displaying symptoms of a mild case of Serotonin Syndrome. Thankfully, though, the symptoms seem to be subsiding, and I am slowly (albeit too slowly for my taste) feeling somewhat better. I looked up the treatments for mild cases of Serotonin Syndrome, and it seems to consist of discontinuing the drugs that caused it and helping the person control agitation, possibly with a benzodiazepene. I'm definitely NOT taking any more DXM or SAM-e today, and I'll probably discontinue the SAMe for a couple of days to ensure my safety. I've been listening to chill music and doing some nice deep breathing to stay relaxed - typing this up on BL helps too, for some reason. I don't have any benzos, but that would certainly be nice. I'm not feeling hot anymore either, but I may take a cool shower later, and I'm going to continue drinking water. I told my roommate what's up, too, and I wrote down what I took (800mg SAM-e per day + 135mg DXM) on my hand in Sharpie just in case anybody needs to know and I can't tell them myself for some reason.
Anyway, from the little bit of research I've done, I think I will be fine. It seems as though mild cases of Serotonin Syndrome resolve themselves withing 24 hours of discontinuing the drugs. And again, I am feeling a bit better already. However, if anybody has any advice for me, I'd really appreciate it. I guess my take-home message, though, is that you shouldn't mix SAM-e and DXM! Don't take DXM if you are on ANY DRUG that elevates serotonin levels. (I already knew you shouldn't mix SSRIs and DXM, I guess I just didn't stop to think - this time.) Oh, and if anybody has any information on what outcome I can expect from a mild case of Serotonin Syndrome, I'd really appreciate that too.
Peace
I just want to add to this that you should take SAM-e seriously if you are taking it. It has actually had some marvelously powerful effects on my mild depression over the last few days, and I've found it very beneficial so far. So, from this experience that I've just had and am still having, I would say that if you are planning on taking drugs recreationally and are also taking SAM-e, treat it like you were taking an SSRI or tricyclic or something and plan your future drug use accordingly. Again, I feel like I'll probably be fine, but this is by no means pleasant.
Anyway, from the little bit of research I've done, I think I will be fine. It seems as though mild cases of Serotonin Syndrome resolve themselves withing 24 hours of discontinuing the drugs. And again, I am feeling a bit better already. However, if anybody has any advice for me, I'd really appreciate it. I guess my take-home message, though, is that you shouldn't mix SAM-e and DXM! Don't take DXM if you are on ANY DRUG that elevates serotonin levels. (I already knew you shouldn't mix SSRIs and DXM, I guess I just didn't stop to think - this time.) Oh, and if anybody has any information on what outcome I can expect from a mild case of Serotonin Syndrome, I'd really appreciate that too.
Peace
I just want to add to this that you should take SAM-e seriously if you are taking it. It has actually had some marvelously powerful effects on my mild depression over the last few days, and I've found it very beneficial so far. So, from this experience that I've just had and am still having, I would say that if you are planning on taking drugs recreationally and are also taking SAM-e, treat it like you were taking an SSRI or tricyclic or something and plan your future drug use accordingly. Again, I feel like I'll probably be fine, but this is by no means pleasant.
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