Misc DXM daily usage..

[Thorns Have Roses]

It isn't OTC where I'm living. I've used hydroxyzine ED long time at evening doses of 75-100mg. Yes it is beneficial but not relaxing enough. Also would those other antihistamines be any better than hydroxyzine because isn't it that hydroxyzine is the only one that works also as 5HT2c antagonist and offers anxiolytic effects mainly because of that? I have used also doxylamine succinate and it was ok but maybe not as good as hydroxyzine for sleep. Diphenhydramine I maybe should try if I just get it somewhere.

What kind of topsy-turvy land has diphenhydramine by prescription and OTC hydroxyzine? Anyway, hydroxyzine should be quite superior to diphenhydramine or doxylamine for your purposes.

 

[mal3volent]

Realistically if you are doing this for any length of time you should do an extraction on syrup, a la Agent Lemon.

Since you seem to know your shit, I tried this two times and never could get the layers to separate... I've been told I didn't get the right kind of ammonia. I read a guide that used great value brand clear ammonia so thats what I got, but its got surfactant or w/e and I hear thats what fucked me up... so... specifically, is there a brand of ammonia out there you could suggest, if that is my problem. (I searched for a long time but found conflicting answers to this question) Thanks.

 

[Swimmingdancer]

Sorry for the delay in replying, I didn't see your post until now and it's quite a lot to reply to.

First off, thank you for your answer!

And second off, I have taken much of drugs (phenibut, lyrica, tramadol, benzos) tonight and they makes me kind of emotional. So hope you don't be too judgemental against me now when I'm speaking from my heart. I appreciate your answer very much and it makes me feel good also because I've been thinking lately that my posts here don't seem to get much of replies compared to many others. I'm wondering if my language is so bad that its hard to find out what I'm trying to say (english isn't my native language anyway)? So now this really feels good when you answered and tried to help me. Altough I'm not sure if they offer me excatly what I'm looking for and so my replies aren't in line with you. I try to be honest with you and my apologies if that insults you it isn't my purpose.

You seem very nice and your English seems great If you are reduce your intake other meds and help with withdrawals and weren't just referring to just regularly using DXM indefinitely, I do think that makes things a bit different. It's great that you've tried so many other things and have done so much research. I guess my advice would be to try to use the DXM as little as possible and alternate it with the herbs and supplements you've found to work for you. It's good not to rely on any one thing anyway and will help keep tolerance down and help prevent addiction. Maybe try some more combinations of herbs and supplements too, often a combo works best IME.

Kava I've used many times. It feels someway similar to me with Lyrica wich I use anyway. If I remember correctly its mechanism of action is also partially similar like blocking voltage gated calsium channels? Also I've might felt during this benzo withdrawal it gives me excacerbated rebound effect (maybe because its short duration of action on gaba receptors?) for next day. I'm not sure though and have to test again.

It's still not fully understood how kava works. I've read a bunch of different studies that all had different conclusions. IME if large doses of kava are taken it seems like it can increase drug withdrawals from drugs with apparently totally unrelated mechanisms of action, like opioids, so I wonder if perhaps it increases metabolism of some drugs, flushing them out of your system faster? I stayed with a group of indigenous people who regularly use kava (it's a huge part of their culture) and they claimed it "cleanses drugs and toxins from the system".

I didn't know lysine would be helpful. Haven't used it during withdrawals. So what is its mechanism of action and what doses are needed?

It is supposed to help with benzo tapering and withdrawal, but it also potentiates benzos, so that is something to consider. I know of several people who have used it to lower their benzo dose. I would maybe start with 1g. Here are some threads with info about Lysine:
Nutritional & Herbal Supplements for Anxiety!
(aminos) L-lysine is a barbiturate-like anticonvulsant and modulator of the benzodiaz
L-Lysine + GABA?

It isn't OTC where I'm living. I've used hydroxyzine ED long time at evening doses of 75-100mg. Yes it is beneficial but not relaxing enough. Also would those other antihistamines be any better than hydroxyzine because isn't it that hydroxyzine is the only one that works also as 5HT2c antagonist and offers anxiolytic effects mainly because of that? I have used also doxylamine succinate and it was ok but maybe not as good as hydroxyzine for sleep. Diphenhydramine I maybe should try if I just get it somewhere.

Antihistamines can decrease anxiety and cause relaxation and sedation because of their histamine antagonism, but because hydroxyzine also has 5HT2c antagonism and doesn't have significant anticholinergic effects it is better for anxiety, I just suggested diphenhydramine because it's OTC where I live. Anyway, tolerance grows quickly so I wouldn't recommend using antihistamines very frequently.

Kratom might be good and I've tried to order it one time online but it went to customs. Its illegal where I'm living and hard to find so I haven't had acces to try it. Now when you reminded me I might have to try again get it somewhere.

Be careful if you try kratom as it is an opioid and can cause dependence. It's not something you want to use on a regular basis for that reason, but it you are trying to reduce your intake of stronger opioids it can be helpful.

What kind of effects I was hoping when I said I would need something to relax during this very long tour in hell I was thinking some substances that gives you lets say "deep brain massage" like benzos and opioids together. Of course I can't get excatly the same effects from anything else besides themself but the DXM has been very very close to it. So I was hoping to find something similar to DXM or benzos and opioids.

There's definitely a lot of us searching for something that is healthy and non-dependence causing that feels like a benzo or opioid or helps significantly with withdrawals I think it's very hard to find anything that quite compares to an opioid or a benzo after using those.

How often substances have both neurotoxic and neuroprotective effects? If so could you provide example. I don't know.

There are actually many substances that can be both neurotoxic and neuroprotective. Most NMDA antagonists have been shown to have both neuroprotective and neurotoxic effects (such as ketamine, isoflurane, nitrous oxide, phencyclidine etc). A couple other examples I've seen are Wormwood and certain hormones. (I can post some studies if you like).

Also I don't think ex. my kind of situation and DXM use is directly comparable or at same line to tu usual cases where people abuse DXM. I don't think this should be generalised in one direction or another.

True, but I don't think you can extrapolate the studies on DXM as a neuroprotective agent to your situation either.

It might be benefits in ex. during benzo withdrawal are greater than harms.

True. My saying that DXM was probably not healthy to take on a regular basis was a general statement based on your original question and not about whether the possibility of harm is worth the benefits for you personally.

Also must get back to those inactive ingredients in cough syrups. I wouldn't still think it is not nowhere near as bad as it has been suggested in this thread and elsewhere.

Of course the adverse effects of the inactives in the syrups depend greatly on how much, how much you take and how often you take them, and your health. I certainly didn't mean that the worst case scenarios those ingredients are capable of causing are going to rapidly happen to you from drinking some syrup once, or now and then, just pointing out that the ingredients definitely aren't good for you. Neither is a eating a lot of junk food and drinking a lot of soda on a regular basis. I would personally try to get a DXM prep with as little of those inactives as possible because why not try to avoid unhealthy things that aren't necessary?

I don't know where you get that information but glycerol isn't dehydrating instead it is very hydrating. I'm bodybuilder and have used glycerol several times for hydrating purposes (better muscle function). It is very effective plasma expander and it will hydrate your muscles and skin. Your skin will come very smooth, moist and good looking with it. Try it if you dont believe me; it can be found from nutritional supplements used for bodybuilding and other purposes or then pure. I've used pure vegetable glycerin and it works wonders.

Maybe the source I used for the info about the glycerol was inaccurate, can't remember the link. Glycerins are well known to cause mucous membrane irritation and dryness in many people, this definitely happens to me. So perhaps that's why they said "dehydrating". Also many DXM syrups have worse glycerins than glycerol. Anyway, the info about the inactives was in response to someone asking and was meant to be seen as a whole, not to imply that taking a small amount of any single ingredient once was going to seriously harm you.

I hope you people have patience and let objectives and issues argue and fight against each others - not persons. I'm not against anyone here just interested to research and solve matters.

Same here I have an open mind and am willing to change my mind about things. It's refreshing to have discussions on the internet that remain kind and respectful even when people may not agree about everything. One thing I love about Bluelight is that it is a great place to learn about things, and I am always open to learning from others

I will try to find some studies on DXM for you. I don't think the kind of use you are talking about has been studied. Whether or not DXM is neurotoxic is really controversial and my view was that it's safest to assume that it is instead of assuming it isn't, and going by anecdotal reports it does seem to be damaging to regular users in a number of ways. Often anecdotal reports are ahead of the science when it comes to adverse health effects of drugs IME.

 

[Trylandair]

I was working on Tussin everyday for a while, took the anxieties out of serving people in high pressure situations. I noticed that every time I ate a meal it would kill my high pretty quickly, which isn't necessarily a bad thing since if something important came up I knew how to quickly get back to normal. Very handy.

I'm interested in ways to sober up quickly in case of bad trips with other compounds as well. I know with alcohol, food and water work pretty well, but there is a high chance of vomiting. With stimulants xanax worked for me (food & water did not), the huge amount of stress went away as if I was just imagining it. To me the more common the remedy, the better though, so I also tried aborting a low dose tryptamine by eating and that worked just fine.