DXM and Wellbutrin? WHo would have thought!

[XRufio84X]

I am on DXM as I'm trying to type this lol. :D I'm VERY experienced with DXM. I'm tripping and having OEV's WAY more than CEV's. I also just started taking Wellbutrin a week ago and IT's like I don't need as much DXM! Like I'm 185 Pounds and normally go for 3rd and 4th plateau trips (what can I say, I like Hallucinating and Getting in my head). So basically I take about 1400 MG Pure DXM to be at the 4th plateau (before the wellbutrin was introduced.) Now it's like all I need is 350mg to get to the 3rd or 4th. Crazy. I'm also using a Brainwave Generator. I'm telling you, it works and completely enhances your trip. You could either download it or in my opinion, get these IPhone (maybe other smart phones/IPod 's too) apps called "Mind Tuner" and "Brainwaves". Both separate apps and free. Check the web for how that all works with the brainwave generator. It kicks your trip up majorly, in a good way. But anyways, I'm experiencing a light show in my dark bedroom haaha. Lights in the dark, the floor moving, seeing things that aren't there (not scary) but dang. It's almost 5AM and I dosed at 9PM and stillll trippin. Not tired. Feeelin great. Man it took so much exertion to type this. Whew. Peace

 

[JackiesBabyy]

I am on DXM as I'm trying to type this lol. :D I'm VERY experienced with DXM. I'm tripping and having OEV's WAY more than CEV's. I also just started taking Wellbutrin a week ago and IT's like I don't need as much DXM! Like I'm 185 Pounds and normally go for 3rd and 4th plateau trips (what can I say, I like Hallucinating and Getting in my head). So basically I take about 1400 MG Pure DXM to be at the 4th plateau (before the wellbutrin was introduced.) Now it's like all I need is 350mg to get to the 3rd or 4th. Crazy. I'm also using a Brainwave Generator. I'm telling you, it works and completely enhances your trip. You could either download it or in my opinion, get these IPhone (maybe other smart phones/IPod 's too) apps called "Mind Tuner" and "Brainwaves". Both separate apps and free. Check the web for how that all works with the brainwave generator. It kicks your trip up majorly, in a good way. But anyways, I'm experiencing a light show in my dark bedroom haaha. Lights in the dark, the floor moving, seeing things that aren't there (not scary) but dang. It's almost 5AM and I dosed at 9PM and stillll trippin. Not tired. Feeelin great. Man it took so much exertion to type this. Whew. Peace

That's odd. Wellbutrin is a DNRI similar to amps, and amps are considered a bad mix with DXM because of too much norepinephrine.

 

[XRufio84X]

"That's odd. Wellbutrin is a DNRI similar to amps, and amps are considered a bad mix with DXM because of too much norepinephrine."

No bad symptoms at all. It's potentiating the DXM and I dont have to drink as much.

 

[Drownrat]

Don't combine welbutrin (bupropion) with DXM, you run the risk of serotonin syndrome. If you want to potentiate your DXM experience buy a bottle of white grapefruit juice and drink it from the time you wake up until the time you take the DXM.

 

[Jesusgreen]

Wellbutrin is a norepinephrine-dopamine reuptake inhibitor. It doesn't have a direct effect on serotonin and so should be safe to combine with DXM provided the doses stay low.

Also, amphetamines are primarily releasers rather than reuptake inhibitors - examples of other NDRIs would be Ritalin (methylphenidate), cocaine (which is also a serotonin reuptake inhibitor), and MDPV.

Although it's a safe combo if you keep the doses quite low not everyone will enjoy it as DXM has significant stimulant effects in its own right and this combination could be uncomfortable stimulating. Once you reach higher doses, you risk putting too much strain on your heart, so it could be quite dangerous.

 

[thedeadlywar]

Don't combine welbutrin (bupropion) with DXM, you run the risk of serotonin syndrome. If you want to potentiate your DXM experience buy a bottle of white grapefruit juice and drink it from the time you wake up until the time you take the DXM.

I have to agree with this 100 percent, wellbutrin has a long list of drugs that interact with it in this way and dxm is definitely one of them. there's no real point to combining them because its honestly not going to give you any real potentiation, just negative side effects and a risk for seizing/serotonin syndrome. Just.. ugh to this combination.

 

[Dondante]

Careful with this combo...there are plenty of reports on Erowid of negative reactions, including severe urinary retention, unexpected potentiation, or symptoms resembling serotonin syndrome. Interestingly, there's also a report of persistently elevated mood from a combination of low dose DXM/GABA/bupropion. From the TR, "...this may not work for you, or may have negative side affects for some individuals. It made my girlfriend nauseous-to the point of being stuck in bed all day- while on the other hand, it has and continues to make my life wonderful to the point of extacy all day long-with no hangover effect."

DXM and bupropion are both metabolized by the same enzyme (CYP2D6) AND bupropion (or more accurately one of its metabolites) happens to be a strong inhibitor of the CYP2D6 enzyme. What this means is that the combination will lead to significantly increased levels of both drugs. One study predicts that with 300 mg bupropion, blood levels of DXM would be increased to 1000% of normal! It's important to keep in mind that high levels of DXM aren't necessarily desirable. DXM is essentially an SNRI (thanks to sekio for correcting me last time), which means it could result in serotonin syndrome. Also, DXM doesn't have dissociative effects on its own...it's DXO, a metabolite, that is the NMDA antagonist (i.e. responsible for the dissociation).