At this moment I am taking very low doses of duloxetine (about 5-10 mg daily) trying to withdraw the drug totally. Sometimes I am not using the drug for 2 or more days, what mean I am at 4+ half-lifes of drug from the last dose, and simple math tells me there is almost no drug in my system at this time. Despite this I am paraoid about possible serotonin syndrome and am afraid to take even 1 small 15 mg tab. of DXM. I want to try 1st plateau dose of DXM, but do not want to risk, if the risk is present. Is the possibility of serotonin syndrome dependant only on the concentration of serotonergic drugs in system, or there are possibilities it may happen with increased chances due to disregulation of receptors after long term SSRI usage? Are the recommendations not to use any MAOI or serotonergic agent 2 weeks after SSRI based on Prozac long half life (2-3 days vs 12 hours of duloxetine; 3 days stopping duloxetine will mean you are in 6+ T1/2 "zone"), or it is something what is common to all the SSRIs?