To answer your question: it depends. How drunk do you want to get, how old are you, are you male or female, body type, age? Since you're asking this to randoms online, I'm guessing that you're fairly young and naive, in which case I'd say that a small (half?) bottle of wine would get you tipsy on its own. Don't mix. If you're drinking wine, stick with wine. Mike's Hard is shit, but a bottle is equivalent to a single 'drink', while a half-bottle of wine is closer to two.
Yup. Alcohol's a pretty blunt instrument when it comes to drugs. Really though, unless OP is a tiny, completely naive user lacking alcohol dehydrogenase then chances are they will only get half-drunk. Which really is probably for the best.