• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Drug designs. (MedicinalUser SAR thread)

Smyth2 said:
Hey 3DQSAR, i understand you're concerns that some of the above reading appears academic and not that practicably feasible.

I like you thought of novel ideas based on 4-piperidone. Without having to invent anything new I can show you an existing idea I already discovered (I posted it in the novel opioid thread but am reposting it here):

I call this one Haldolgesic
4-(4-Chlorophenyl)-1-(1-phenylethyl)-4-piperidinol
[63959-34-2]

Link patent:
Toshiaki Kumazawa, et al. WO1997010213 (to Kyowa Hakko Kogyo Co Ltd, US Department of Navy).

Source matter:
Leysen, Josee, Jan P. Tollenaere, Michel H.J. Koch, and Pierre Laduron. “Differentiation of Opiate and Neuroleptic Receptor Binding in Rat Brain.” European Journal of Pharmacology 43, no. 3 (June 1977): 253–67. https://doi.org/10.1016/0014-2999(77)90025-5.
Click to expand...
Why the para chloro? Meta hydroxy may work, I though of the N-Methadyl analog, but its possible its too bulky and PGP may effect it.
 
The traditional prep of bufotenine seeds uses calcium carbonate, a slow dehydrogenation route is theorised to occur via this intermediate:

image.png
 
Last edited:
The 5-methoxy tryptamines are strong but do not sound like they are funner than regular AMT or DMT.
 
Here's the full theorised route with bufotenine and calcium carbonate. I checked with a mod to make sure it was ok to post.

image.png
 
You must log in or register to reply here.
Top