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Drug designs. (MedicinalUser SAR thread)

I call this one Sentinel-4. Its molecular structure is 1-(2,4-dimethylazetidine)-4-(2,4-dimethylazetidine)-phenyl.
 
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Smyth2 said:
These compounds have the same aryl group so a proven pharmacophoric building block:

NS9775
6-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)naphthalen-2-ol.HCl
Fb: PC11499781 HCl: PC67403453

Andreasen, Jesper T.; Redrobe, John P.; Nielsen, Elsebet Ø.; Christensen, Jeppe K.; Olsen, Gunnar M.; Peters, Dan (2013). "A combined α7 nicotinic acetylcholine receptor agonist and monoamine reuptake inhibitor, NS9775, represents a novel profile with potential benefits in emotional and cognitive disturbances". Neuropharmacology. 73: 183–191. doi:10.1016/j.neuropharm.2013.04.060.

Also see WF-33
en.wikipedia.org

2α-(Propanoyl)-3β-(2-(6-methoxynaphthyl))-tropane - Wikipedia

en.wikipedia.org en.wikipedia.org

I doubt that any of your compounds actually fit the receptors and are almost impossible to make for mostly all of them.

I'm not sure the software you are using but chemdraw is unable to recognize most of the names you are using.
Click to expand...
That looks nothing like MDMA.
 
I call this one Sun-Rise. Its molecular structure is 9-bromo-8,10-dimethoxy-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-methanamine.
 
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I call this one Mixer. Its molecular structure is [(7R)-3,4-dibromo-2,5-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl]propan-2-amino-(1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phencyclopropane-carboxamide.
 
I call this one 25-Thio-TCB-2. It's molecular structure is 1-bromo-2,5-dimethoxy-thiophene-N-[(2,5-dimethoxy-thiophene)methyl]propan-2-amino[(7R)-4-bromo-2,5-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl]methanamine.
 
I call this one Trypt-O-Wack. Its molecular structure is 1-isopropyl-4,5-dimethoxy-6-tribromomethyl-N-2,4-dimethoxy-azetidine[(1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-carboxamide]tryptamine.
 
Rectify said:
N-phenylamphetamine, anyone?

Electrochemical deoxygenative amination of stabilized alkyl radicals from activated alcohols

Now available from ACS.
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I just checked my notes and found an analog i drew out.

Since Ampyzine is already a stimulant for the last step you condense it with methamp instead of dimethylamine.
 
anh.. This one probably already exists, but I'll post it anyway. I call it para-MethoxyFLY. Its molecular structure is 1-(4-methoxy-2,3-furan-5,6-furan-phenyl)propan-2-amine.
 
I call this one para-Methoxy-M-FLY. Its molecular structure is 4-methoxy-2,3-furan-5,6-furan-phenyl-N-methyl-1-propan-2-amine.
 
I call this one Bromo-Creeper. Its molecular structure is 1-(4-bromo-2,3,5,6-tetra-methoxy-phenyl)propan-2-amine.
 
I call this one Bromo-Smooth-Creeper. Its molecular structure is 1-(4-bromo-2,3,5,6-tetra-methoxy-phenyl)propan-1,2-diol.
 
I call this one Hammer-Head. Its molecular structure is 1-(4-(2,4-dimethylazetidine)-2,3-furan-5,6-furan-phenyl)propan-2-amine.
 
I call this one Methyl-Hammer-Head. Its molecular structure is 4-(2,4-dimethylazetidine)-2,3-furan-5,6-furan-phenyl-N-Methyl-1-propan-2-amine.
 
I already designed this one. Tell me if the IUPAC numbers are any better. 1-(4-bromofuro[2,3-f][1]benzofuran-8-yl)-N-[(2,5-dimethoxyphenyl)methyl]propan-2-amine.
 
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