Drug combination to closest mimic LSD-25 neuro-receptor activation?

[cannibalsnail]

[Moderator comment: this is not a question about what to take, this is an investigation into pharmalogical profiles only]

What drug combination would closely mimic the unique neurotransmitter profiles of LSD?

LSD activates the following neurotransmitters to some extent:

5-HT2a
5-HT2c
5-HT1a
5-HT1b
5-HT1d
5-HT5a
5-HT6
5-HT7
D1
D2
D3
D4
alpha2

To my knowledge most Phenethylamines only activate 5-HT2a + 5-HT2c and Tryptamines activate 5-HT1a as well. Are there any drugs with recreational value that when taken in the right doses could mimic the activation profile for the remaining neurotransmitters?

 

[sekio]

This is not really suitable for Advanced Drug Discussion - maybe Psychedelic Drugs? Let's see how it fares there.

As far as I know there is no drug or set of drugs that replicates an LSD experience except LSD itself. There are some that produce qualitative experiences similar to LSD (i.e. strong psychedelic effects at milligram doses), but those aren't LSD now, are they? Even other ergolines do not substitute exactly. Some compounds that do "seem" like a good substitute, like the NBOMe series, are not 1:1 replacements and require different consderations (i.e. they are nnot orally active, dosing and timing is different, etc) Getting into "legal" or "easily availiable" drugs is not something we talk about here on Bluelight, though.


Phenethylamines and tryptamines activate far more than just 5-HT2a and C. Here is an excellent study to read up on; especially the excel file attached.

 

[Limitbreaker]

Tregar suggests: Mescaline + 25I-NBOMe.

 

[Solipsis]

As has been pointed out elsewhere it is not that simple, that you can just take a combo of separately active compounds to get it to synergize in a way that resembles something like LSD unless one of the drugs in the combo by itself comes close to it, in the above case both drugs to to a significant extent but 25I was mentioned to be one LSD-like drug itself.
The mechanism is more tricky than trying to combine a set of monoamine releasing or reuptake inhibiting compounds to try and mimick MDMA. But even that is a hard one, because a few special effects of MDMA are not often found in other drugs so there will be something missing a lot of the time. Coming close? Perhaps.

Because of the rules I will edit the OP to be formulated differently. Comparison threads are right there on the edge but 'what should I take?' threads are not allowed. If users reply to that question the thread will be shut down. I am okay with comparing receptor affinity profiles, it is an interesting subject but everyone should do with that information what they think is right and if it is not clear enough, do more research on all involved or mentioned compounds.

There is discussion allowed that covers the combination of stimulants (dopaminergic + serotonergic + possibly norepinephrinergic) to try and achieve novel empathogen results so it would not be fair to disallow the same about this. But prepare for heavy moderation if we see fit and even closing of threads like this.

 

[Solipsis]

I saw someone post something about lsa and 2ce being a good combo to bring out
lsa's visuals with a nice headspace. Vasoconstriction was mentioned though.

also doi, dom maybe,

still, none of these are that close.

acid is unique, simple, perfect.

LSA misses significant activity but would lend the feel of a lysergamide, hinting towards LSD especially when LSD has a body load that
can be felt heavily. 2C-E is a very effective psychedelic, analytic, it reminds a lot of people of acid.

I already see this thread going in the wrong direction.
OP, you cannot get close to the profile with very standard psychedelics like these. They have too much of their own character. It seems you cannot get LSD itself, well then if you still want to experience it look further. Other combinations should be explored in their own right, basically what you are looking for is something with a potent 5-HT2A activity, yes the rest matters but looking at the NBOMe's they don't matter enough to not make some of them feel similar to LSD. The less selective compounds, probably a number of what you might be able to get, they just don't cut it so stop the quest. Instead research the compounds available to you and see if something about them appeals to you. There are an infinite number of psychedelic modes you can find, and there is no shame in just starting at the beginning. Have patience
in the meanwhile.

Basically this thread is hijacked and meant for posts that supply receptor affinity data that would help match the profile, and also discussion is welcome on which receptor activity is not really that significant and which ones are. It might after all belong in ADD, but they may not like it there. Hopefully some users with knowledge of medicinal chemistry have something of value to add, but other simple suggestions will be removed if not joined by reference data. Sorry.

 

[cannibalsnail]

I was actually hoping for a more neuro-science centred discussion, comparing Ki values for different neuroreceptors etc. hence why I posted in ADD.