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Drinking your own urine

C

CrimpJiggler

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Joined
Aug 28, 2011
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I first learned about it when reading about Siberian mushroom shamans who drink their urine, or the urine of reindeers after ingesting Amanita muscaria mushrooms as the toxic ibotenic acid is metabolised but the muscimol is excreted intact. As insane as it sounds, urine is relatively sterile and assuming one has a reasonably healthy diet and hasn't ingested a variety of drugs, its non toxic and relatively safe. The drug I have in mind at the moment is gabapentin. It has a very low bioavailability and the body does not metabolise it at all, it is excreted by the kidneys intact. Other polar drugs like amphetamine are also largely excreted unmetabolised. Then there are drugs which have active final metabolites (i.e. morphine-6-glucoronide). Morphine has other metabolites (i.e. morphine-3-glucoronide) so I don't know if this would work in that case. For gabapentin, I'm positive it would work.

After researching it a bit, I see theres actually an alternative medicine practice called urophagia or urine therapy. I know I'm gonna be flamed for this but I just went ahead and did it. I pissed in a bottle and drank it. I tasted it first and surprisingly, it just tasted like water with a bit of saltiness to it. It felt too weird drinking it straight so I added some citric acid and it tasted just like lemonade. I know how insane it sounds but if its good enough for Siberian mushroom shamans, its good enough for me.
 
Did you feel the effects of the gabapentin? or did you just drink a cup of piss for nothing? what opiates might this work for? im going to bed or i would research myself, but if you could post a list of chems that this would work for i will be a lab rat in this little experiment and post some piss reports on here. this is very intresting. if this works for opiates then maybe a person who is dopesick could drink a cup of piss and lessen their withdrawl symptoms, for free! hahaha. this is absolutley insane by the way. but like i said, if you could find a list of substances that are eliminated intact in urine then i will def be a guinie pig in this experiment. ive drank alot worse things than piss so this shouldnt be too hard. and also before i do this, please give us a reference to where you found out that drinking urine will in fact give psychoactivity. i dont wanna drink my piss for nothing. and also, any ideas on how to make it taste better? I guess i could make a Pissy Mary....very intresting nonetheless.
 
'Piss reports' - lmao

It's not really outlandish, there are considerations however. Urine is high in sodium, minerals, and at times toxins, so you have to make sure you drink plenty of water. Also, if you have an undetected acute infection in your bladder or kidneys, recycling the urine could serve to spread the infection.

I would start with pregabalin instead of gabapentin as it has a return of 90% unchanged in urine.
 
ryand123 said:
Did you feel the effects of the gabapentin? or did you just drink a cup of piss for nothing? what opiates might this work for? im going to bed or i would research myself, but if you could post a list of chems that this would work for i will be a lab rat in this little experiment and post some piss reports on here. this is very intresting. if this works for opiates then maybe a person who is dopesick could drink a cup of piss and lessen their withdrawl symptoms, for free! hahaha. this is absolutley insane by the way. but like i said, if you could find a list of substances that are eliminated intact in urine then i will def be a guinie pig in this experiment. ive drank alot worse things than piss so this shouldnt be too hard. and also before i do this, please give us a reference to where you found out that drinking urine will in fact give psychoactivity. i dont wanna drink my piss for nothing. and also, any ideas on how to make it taste better? I guess i could make a Pissy Mary....very intresting nonetheless.
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Yeah I'm still feeling the gabapentin about 8 hours after initial ingestion. I only drank it once, if I was to drink it repeatadly, then I'd be recycling all of the gabapentin. I'll do a bit of research and see if it works for common opioids. Opioids tend to have more complex metabolic pathways so I don't think its as simple but this could be exploited to multiply the effects of some opioids because I believe there are sometimes opioid metabolites that are much more active than the drug itself. I watched a youtube video where they installed these resins in urinals that collected urokinases (which have medicinal properties). I bet one could find ways to concentrate particular metabolites while removing undesirable ones (i.e. concentrating morphine-6-glucoronide, while removing morphine-3-glucoronide).

I'll start compiling this list. So far two drugs I know for sure that this works well for are gabapentin (neurontin) and pregabalin (lyrica). They aren't metabolised at all by the body.

I can find plenty of references for Amanita muscaria but for newer pharmaceuticals, I think this is uncharted territory. From what I've read, if you have a bad diet the urine tastes bad, if your diet is good then it tastes neutral. My diet isn't all that good but mine tastes neutral. To make it taste better, you can mix it with any kinda juice. I added some pure citric acid powder (which I got at the pharmacy) and it looked and tasted just like lemonade. I've drank near infinitely worse things too lol. Taking shots of GBL was pretty bad but the worst would have to have been phenibut dissolved in water.

EDIT: Alright I'm starting the list. I'm gonna add drugs that won't work too so we'll know not to experiment with them.

Opioids
Morphine: This won't work for morphine (or heroin or codeine) because 60% of it is metabolised into morphine-3-glucoronide (a convulsant) and only 6-10% into M6G (the active metabolite). A small amount is converted into hydromorphone but it'd be insignificant.
Ref: http://www.news-medical.net/health/Morphine-Pharmacokinetics.aspx

Hydromorphone: Won't work for this either because according to wikipedia, about 95% is metabolised into hydromorphone-3-glucoronide which is an even more potent convulsant than morphine-3-glucoronide.
Refs: https://en.wikipedia.org/wiki/Hydromorphone#Pharmacokinetics
https://www.ncbi.nlm.nih.gov/pubmed/11459432

Oxycodone: This looks promising. Heres what the wiki page says:
Oxycodone is metabolized to α and β oxycodol; oxymorphone, then α and β oxymorphol and noroxymorphone; and noroxycodone, then α and β noroxycodol and noroxymorphone (N-desmethyloxycodone).[3] (14-Hydroxydihydrocodeine that in turn becomes 14-Hydroxydihydromorphine) These metabolites are true only for humans.[21] As many as six metabolites for oxycodone (14-hydroxydihydromorphinone, 14-hydroxydihydrocodeine, 14-hydroxydihydrocodeinone N-oxide {oxycodone N-oxide}, 14-hydroxydihydroisocodeine, 14-hydroxydihydrocodeine N-oxide, and noroxycodone) have been found in rabbits,[22] several of which are thought to be active metabolites to some extent, although a study using conventional oral oxycodone concluded that oxycodone itself, and not its metabolites, is predominantly responsible for the drug's opioid effects on the brain.[3]

Oxycodone is metabolized by the cytochrome P450 enzyme system in the liver, making it vulnerable to drug interactions.[2] Some people are fast metabolizers resulting in reduced analgesic effect but increased adverse effects, while others are slow metabolisers resulting in increased toxicity without improved analgesia.[23][24] The dose of OxyContin must be reduced in patients with reduced hepatic function.[7]
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So the final metabolite is hydromorphinol: https://en.wikipedia.org/wiki/Hydromorphinol
which has a similar potency to morphine. One really needs to research this well before experimenting I think. One should research all the compounds in that metabolic pathway because I think some of them will also be excreted in the urine.

Ref: https://en.wikipedia.org/wiki/Oxycodone#Metabolism

Ibogaine:
I think it works for ibogaine. According to this article: http://www.eboga.fr/Addiction/Ibogaine-A-Review.pdf
its major metabolite is noribogaine (which is more active than ibogaine itself) and I haven't heard of noribogaine being metabolised further. This knowledge (along with knowing oxycodones metabolic pathway) may be useful to opioid addicts in withdrawal because ibogaine is very expensive and people usually need to dose with ibogaine about twice a day to keep withdrawal symptoms at bay.


Cannabinoids:
It may work for THC. According to the wiki page, most of the THC is metabolised into 11-hydroxy-THC: https://en.wikipedia.org/wiki/11-Hydroxy-THC which is active. 11-OH-THC is further metabolised into 11-nor-9-Carboxy-THC though which is inactive. 11-nor-9-Carboxy-THC is then conjugated with glucoronide, I'm not sure if the adduct is active or not.
Ref: https://en.wikipedia.org/wiki/Tetrahydrocannabinol#Metabolism
https://en.wikipedia.org/wiki/11-Hydroxy-THC
https://en.wikipedia.org/wiki/11-nor-9-carboxy-THC

Amphetamines:
According to wikipedia, a large amount of amphetamine is excreted unmetabolised. For the percentage of it that is metabolised, here are the 3 main pathways:
400px-Amphetamine_metabolism.png


Benzos:
I don't have time to research this right now but if I remember correctly, long acting benzos like diazepam and clonazepam have a variety of active metabolites.



I found a thread on recycling psychedelics:
http://www.drugs-forum.com/forum/showthread.php?t=87660&highlight=drinking+urine
 
Last edited:
CrimpJiggler said:
Benzos:
I don't have time to research this right now but if I remember correctly, long acting benzos like diazepam and clonazepam have a variety of active metabolites.
Click to expand...

Exactly.. There have just been an article about fish on oxazepam(and other drugs) because it is pissed out by everybody on diazepam and other benzo's IIRC.
But oxazepam isn't especially potent, so I have my doubts about any noticeable effects..
 
Would you also eat your poo if there was un-metabolised drugs in there too? Maybe it would taste like Indian food
 
^ As in... 2 girls 1 dose ?

Say, don't you keep building up general unavoidable waste products in your body if you drink your own urine?

(it's really all I can do not to post Bear Grylls memes by the way)
 
Sure, you could. I seem to recall there have been a few meth heads who recycled amphetamines out of their urine. Messy process.

The problem in a lot of cases is that your liver likes to tack sugar molecules onto any availiable 'handles' the drug molecule has, in order to excrete it. In addition there are all sorts of other competing factors (distribution to fat, liver metabolism etc) that makes this a generally bad idea for most drugs. You'd probably be lucky to recover 50% of your drug in an active form, unless you collected a whole day's of urine and extracted it.

Personally I would not make a habit of drinking my own urine. It's sterile, sure, but unhygenic and not very appetizing. Also, regular consumption can fuck with your salt balance, because the main route your body excretes salts is that way.

For most drugs this is probably not worth your time. The exception are really, really solid potent drugs like phencyclidine and gabapentin that "pass through" rather than being metabolised. I don't think recovering ~20% of an amphetamine dose in urine is worth trying to drink a cup of piss.
 
Regularly doing this could cause (at least) minor health problems, in the long run, but is probably safe and effective to do on occasion.

Many drugs are excreted unmetabolised, and you'd get more from your drug if you could reuse it after pissing it out. But you can't truly know the potency of your urine, and you'd have some unpleasant experimenting to do in order to determine dosages of straight urine.

Honestly, I think you'd be better off trying to develop an extraction procedure, if you have some knowledge of chemistry. It likely wouldn't be perfect and would produce an impure final product, but it'd be better taking this then straight urine, even if only for pleasant dosing.

lol, I've thought of performing extractions upon my own urine in the past, actually. But by the time I piss out the drug I was on, I was no longer as driven to try an extraction, so I've never actually done it. But I won't say I've never entertained the idea myself, or thought about the money/drugs lost simply by pissing out my psychoactives.

A good urine extraction procedure for common urine-excreted drugs, likely one procedure for each substance, would be a great tool. If you can somehow extract the one psychoactive exlusively, or relatively exclusively, you can save your money and get more "high" from the same amount of drug. There are several occasions in my recent experiences when I would have warmly welcomed extraction procedures like that.
 
I've met someone who did the urophagia thing, and they directed me to a website that tells you how to do it. You're not supposed to drink a whole bottle at once, you start with small doses (10-30 drops) and then increase your dose over a period of a couple of weeks. They claim that it does so many different things for the body but I can't really understand how it would work. Maybe if you have a really healthy diet you would just be recycling some nutrition, but urine contains urobilin which AFAIK is toxic. I dunno, seems like quackery to me. If your body is trying to get rid of something then why would you drink it?

I remember reading a classic Chinese medicine text that said for post-partum painful blood obstruction, they used to give a bunch of herbs to the woman that were decocted with alcohol and the urine of a boy under 5 years old. It had to be boy's urine, for some reason it moves post-partum blood that is blocked in the vessels. They also define it as "tonifying yin and yang". Yin is the substance of the blood, like minerals, hormones, etc. Yang is the active energy and metabolic warmth that the body generates. Somehow urine increases these.

Now that I'm looking at Wiki, it seems like a lot of cultures used to drink urine as part of medicine. There must be something to it then?

I don't think I'm so cheap that I would drink my urine to maximize my drug intake though...
 
Blegh..I've been pretty desperate, but not this bad. But, yes, its true the shamans do this re/ the amanitas. They will also kill reindeer they see eating the mushrooms and butcher it immediately.
 
I forgot where I read that, I really have no idea what they do with it. Maybe the goodies get into the meat, or they drink the blood or something??
 
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