Doxycycline and MDMA.

[JWills20]

Hey all, SWIM wants to take MDMA. Haha only joking. I'm going to a rave this Friday with my friend who wants to take MDMA with me. He's just recently been prescribed doxycyline (100mg per day) for his eyes and told me it is a CYP34A inhibitor so i'm doing some safety research about the combination. I've read that CYP34A is partially responsible in the metabolism of MDMA and it may therefore potentiate it. I also read that it is somewhat neuroprotective which is cool. He's tried 120mg before and found it too intense so i'm suggesting 80mg's due to the possible potentiation from the doxycycline. Since the combo appears to be safe in regards to acute adverse effects, i'm more interested in getting the perfect dose-response for him. Its tricky since 120mg was too strong without doxcycline but the effects tend to reduce significantly below 100mg (or Erowid would suggest). I'm wondering what a low-ish dose of MDMA in combination with a CYP34A inhibitor will be like for him.

I've posted in ADD but no response, if anyone can give experiences with the combo or specifics i'd really appreciate it.

Thanks guys.

 

[Folley]

IIRC, Sam was on this for a while. I think he abstained from rolling the whole time though...


Once you start getting into drug combinations like this, things get a bit tricky.. and rather dangerous really. I don't have any information for you, and I really doubt you're going to find anything really detailing the interaction between the two.. so good luck to your friend.


Also, tell him to get on Bluelight. We don't really like to have to tell you to tell him to do something.. we would much rather he read the thread and made his on decisions from the information given to him (if there is any )

 

[JWills20]

I prefer to sort everything out though because I know what i'm doing and he has no idea. If he does decide to go for it i've told him what to expect etc. I'm confident the combination is safe with low doses of MDMA, but I don't want his vision to be so fucked he can't even see people's faces haha.

I'll have a further poke round the internet.

 

[Darksidesam]

Yoooo Jwills,

You cant take mdma on that mate.

Actually funny thing was, i was so addicted to ketamine at the time, i really wanted to do it,
I was prescribed this shit for 28 days (it fucking ruins your stomach dont it)

On day 26 i give in and did 300mg line of K which because of the use of enzymes in the liver from the doxy, i felt very slightly wonky for 10 mins and that was it LOL

what a waste..
I personally wouldnt drop knowing im on something that could interfere with my mdma experience or cause an unpleasant experience or death.

Id rather be sober

 

[JWills20]

Hey Sam, cheers for your concern but theres nothing out there suggesting that it could cause the experience to be unpleasant or result in death. All the stuff seems to suggest that the experience will be stronger and last longer and even act as a neuroprotective agent as the enzyme is responsible for the metabolism of MDMA into toxic metabolites.

Ketamine is also a different drug to MDMA - different enzymes etc etc. I've no idea how a CYP34A would affect Ketamine but by the sounds of your experience, it diminished the effects entirely.

I'm hoping someone will reply to me in ADD, I might even make a separate post in there to get people's attention.