With any psychedelic there may be a risk of HPPD, but there's probably a genetic component to that as well, so some people will get it, others won't. I'd imagine the same risks to dopaminergic pathways, especially in the nucleus accumbens & amydgala, that you have with amphetamines would be present with DOx's. But you really only start to see those problems become permanent with prolonged use or massive doses. Neither of those would be appealing with DOx's, in my opinion, so you should be relatively safe, but I'm certainly not a doctor
