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Downregulation and MDMA tolerance

goodvibes

Bluelighter
Joined
May 11, 2014
Messages
103
So my question is a bit of a scenario that just occurred and I am hoping someone can explain why this happened.

So on day 1 of a music festival I took 2 tabs of LSD and then the following day dosed 250 mg of MDMA, tested. The MDMA didn't really hit as hard as it usually does. My usage averages out to a couple months, so I don't think I am abusing the drug. The come up wasn't as rough as it usually is. It just wasn't that OMG THIS IS AMAZING feeling. I felt good, but not as euphoric as previous rolls of the same MDMA. I think maybe that the LSD caused some downregulation of the receptors that MDMA acts on. I am not quite sure if they act on the same ones or not? Any opinions on this?
 
Who knows really. LSD could have caused some slight tolerance but then again 250mg is a high amount which should've worked anyway. Sometimes MDMA just hits in different and unique ways. The set/setting can play a large role in how it effects you. There's no way we can accurately speculate as to what happened in your brain.
 
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