Dosage MDMA, weight related for real yes or no?

[GaumarolBostich]

Since I am sweeping Reddit subs frequently and dosage is one of the most frequently asked question:
Is weight really the or one of the most important factors for dosing MDMA?

I know that there is some dosage calculators and in almost every discussion someone throws in a key like X,XX mg x kg or lb. Now what is confusing me:
1. In any dosage recommendation on harm reduction sites there is a max dosage recommended. That doesn't align with an overall rule dosage by weight. Why should it be outruled just by crossing a fixed amount?
2. Dosage is about concentration in blood (and then ability to cross the blood-brain-barrier) as far as I know. Yes the amount of blood is aligned with weight, the more you weigh, the more blood. So a) are we talking in absolute % concentration of the substance and b) is the composition of the blood important meaning drinking a lot will spoil the rule?
3. I don't know any pharma medicine that is prescribed by kilo. Maybe the doctor will take your overall weight in account, but I have not seen it mentioned on any package leaflet in the pill box.

I would say that a extreme lean or heavy person should adjust the dosage but there is a broad span of body types which should hit the dosage. But this is pure feeling.

Side quest: A lot of 4-MMC users adapt the MDMA rule by weight. I personally do not see that. My wife is leaner than me and needs more of that substance. This is absolutely no data base of course.

Thoughts or facts? Rost me.

 

[placebonaut]

yes it's related to weight, it's absorption and metabolism driven mainly, iirc MDMA is a little bit lipophilic as well though not sure that's a major factor compared to abosrob and meta.

the max limit is a generally safety guide.

however the often quoted YMMV, everyone is different, stay hydrated, know danger sides, have a trip sitter etc etc

I'm 132kg ~ 300lbs, I can't roll on anything less than 250mg, and I have no tolerance, I've maybe rolled 10 times max in my life.

not advocating taking lots more than the max recommended, you should always er on the side of caution and it's best practice to titrate dosage up to find the minimum dose that will make you roll, and avoid going over the max.

 

[GaumarolBostich]

Thank you for your insight. Puts another personal experience on the empiric data. Unfortunately doesn't solve my logic confusion.

 

[Didgital]

Most if not all drugs are affected by weight. I had a friend who was seriously overweight, well over 300lb. I would take 1 tab of supposed 110ug LSD to get open eye visuals and homie would need 2 to even feel it.

A standard recreational dose is between 0.7mg and 1.5mg MDMA per kg of body weight. so a dose for someone weighing 70kg is between 70mg and 105mg. Also everyone's different biologically/genetics.

 

[GaumarolBostich]

I can follow the thought that an extreme weight related to height has an impact on dosage. I can not follow it in the usual range. Your example of standard recommendation produces the range of 49 mg (70 x 0,7) to 105 mg. Quite a span.

Sorry for being academical, I don't want to question rules working well, but want to understand it.